2017
Adipose tissue macrophages impair preadipocyte differentiation in humans
Liu LF, Craig CM, Tolentino LL, Choi O, Morton J, Rivas H, Cushman SW, Engleman EG, McLaughlin T. Adipose tissue macrophages impair preadipocyte differentiation in humans. PLOS ONE 2017, 12: e0170728. PMID: 28151993, PMCID: PMC5289462, DOI: 10.1371/journal.pone.0170728.Peer-Reviewed Original ResearchConceptsImpaired adipocyte differentiationSystemic insulin resistanceInsulin resistanceAdipocyte differentiationPreadipocyte differentiationMacrophage removalImpaired preadipocyte differentiationProinflammatory immune cellsAdipose tissue inflammationAbsence of CD14Insulin-resistant humansAdipose tissue samplesOil Red ODifferentiation of preadipocytesBariatric surgeryProinflammatory cytokinesInflammatory cytokinesTissue inflammationImmune cellsCytokine secretionAdiponectin secretionAdipogenic gene expressionPhysiologic mechanismsAdipose tissueVAT adipocytes
2009
Differential Intra-abdominal Adipose Tissue Profiling in Obese, Insulin-resistant Women
Liu A, McLaughlin T, Liu T, Sherman A, Yee G, Abbasi F, Lamendola C, Morton J, Cushman SW, Reaven GM, Tsao PS. Differential Intra-abdominal Adipose Tissue Profiling in Obese, Insulin-resistant Women. Obesity Surgery 2009, 19: 1564. PMID: 19711137, PMCID: PMC3181138, DOI: 10.1007/s11695-009-9949-9.Peer-Reviewed Original ResearchConceptsVisceral adipose tissueSubcutaneous adipose tissueBody mass indexInflammatory activityAdipose tissueIR individualsAbdominal subcutaneous adipose tissueOmental visceral adipose tissueInsulin-resistant womenInsulin suppression testDegree of adiposityInsulin-sensitive individualsReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionAdipocyte differentiation genesRegional fat storageIR womenBeckman Coulter MultisizerSmall adipose cellsBariatric surgeryObese womenObese/Mass indexLarge cellsAdipocyte hypertrophy