1996
Neural Mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the "false memory syndrome"
Bremner JD, Krystal JH, Charney DS, Southwick SM. Neural Mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the "false memory syndrome". American Journal Of Psychiatry 1996, 153: 71-82. PMID: 8659644, DOI: 10.1176/ajp.153.7.71.Peer-Reviewed Original ResearchConceptsFalse memory syndromeMemory tracesChildhood abuseDissociative amnesiaEffects of stressMemory functionMemory syndromeNeurobiology of memoryBrain regionsNormal memory functionChildren's memoryTraumatic stressorsSpecific brain regionsNeural mechanismsStressful eventsMemoryAmnesiaExtreme stressBrain chemistryAbuseRecallPsychiatric disordersLong-term alterationsLong-term effectsNormal persons
1993
Psychobiologic Mechanisms of Posttraumatic Stress Disorder
Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M. Psychobiologic Mechanisms of Posttraumatic Stress Disorder. JAMA Psychiatry 1993, 50: 294-305. PMID: 8466391, DOI: 10.1001/archpsyc.1993.01820160064008.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderPathophysiology of PTSDAvoidance of stimuliFailure of extinctionFear conditioningTraumatic memoriesMemory processesAutonomic hyperarousalTraumatic eventsEffects of stressCore symptomsPersistent reexperiencingPsychobiologic mechanismsAdaptive behavioralBrain structuresNeurochemical systemsNeurobiologic mechanismsReexperiencingParallel activationHyperarousalDisordersChronic courseTrauma resultsBehavioral sensitization
1984
Multiple Mechanisms of withdrawal from Opioid Drugs
Redmond DE, Krystal JH. Multiple Mechanisms of withdrawal from Opioid Drugs. Annual Review Of Neuroscience 1984, 7: 443-478. PMID: 6324646, DOI: 10.1146/annurev.ne.07.030184.002303.Peer-Reviewed Original ResearchAcetylcholineAdenine NucleotidesAnimalsBenzodiazepinesCalciumCalmodulinClonidineConditioning, PsychologicalCyclic GMPDopamineDrug ToleranceEnkephalinsFearGamma-Aminobutyric AcidHumansMethadoneNaloxoneNarcotic AntagonistsNarcoticsNeuronsNorepinephrineProtein ConformationReceptors, OpioidSerotoninSubstance Withdrawal Syndrome