2022
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits
Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.Peer-Reviewed Original ResearchMeSH KeywordsDiagnostic and Statistical Manual of Mental DisordersHumansPhenotypeStress Disorders, Post-TraumaticSyndromeVeteransConceptsLocal genetic correlationsCell type-specific expressionVanderbilt University biorepositoryMulti-omics studiesMulti-omics investigationsDorsolateral prefrontal cortex tissueGenomic evidenceLaboratory traitsSpecific expressionCardio-metabolic traitsMillion Veteran ProgramPrefrontal cortex tissueMiR-148GenesGenetic correlationsRegulatory profileTraitsProtein expressionCardiometabolic traitsExpressionVeteran ProgramCortex tissueBiological heterogeneitySplicingPrioritization approachPosttraumatic Stress Disorder in US Military Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study.
Wisco BE, Nomamiukor FO, Marx BP, Krystal JH, Southwick SM, Pietrzak RH. Posttraumatic Stress Disorder in US Military Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35192748, DOI: 10.4088/jcp.20m14029.Peer-Reviewed Original ResearchMeSH KeywordsDiagnostic and Statistical Manual of Mental DisordersHumansMilitary PersonnelPrevalenceStress Disorders, Post-TraumaticVeteransConceptsUS military veteransPosttraumatic stress disorderLifetime posttraumatic stress disorderFunctional impairmentMilitary veteran populationNational HealthMilitary veteransVeteran populationVeterans StudyTrauma exposureStress disorderGreater functional impairmentPTSD Criterion ALife Events Checklist-5Odds of lifetimeWeighted prevalencePTSD prevalenceIndirect trauma exposurePTSD ChecklistPrevalenceImpairmentPsychiatric variablesVeteransContemporary dataCriterion A
2017
A comparison of ICD-11 and DSM criteria for posttraumatic stress disorder in two national samples of U.S. military veterans
Wisco BE, Marx BP, Miller MW, Wolf EJ, Krystal JH, Southwick SM, Pietrzak RH. A comparison of ICD-11 and DSM criteria for posttraumatic stress disorder in two national samples of U.S. military veterans. Journal Of Affective Disorders 2017, 223: 17-19. PMID: 28715723, DOI: 10.1016/j.jad.2017.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultComorbidityDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedMilitary PersonnelPrevalenceStress Disorders, Post-TraumaticSurveys and QuestionnairesUnited StatesVeteransYoung Adult
2016
Probable Posttraumatic Stress Disorder in the US Veteran Population According to DSM-5: Results From the National Health and Resilience in Veterans Study.
Wisco BE, Marx BP, Miller MW, Wolf EJ, Mota NP, Krystal JH, Southwick SM, Pietrzak RH. Probable Posttraumatic Stress Disorder in the US Veteran Population According to DSM-5: Results From the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2016, 77: 1503-1510. PMID: 27631148, DOI: 10.4088/jcp.15m10188.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAfghan Campaign 2001-AgedCohort StudiesCombat DisordersComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleFollow-Up StudiesHealth SurveysHumansIraq War, 2003-2011Life Change EventsMaleMental DisordersMiddle AgedResilience, PsychologicalStress Disorders, Post-TraumaticSurveys and QuestionnairesVeteransYoung AdultConceptsProbable posttraumatic stress disorderDSM-5 posttraumatic stress disorderPosttraumatic stress disorderUS veteran populationPsychiatric comorbidityUS veteransNational HealthVeteran populationVeterans StudyStress disorderPTSD symptomsOdds of moodHigh public health burdenPublic health burdenPopulation-based samplePast-month prevalenceDSM-5Specific PTSD symptomsHigh rateWeighted lifetimeNew symptomsHealth burdenLow prevalencePsychiatric disordersPTSD Checklist-5Shall we really say goodbye to first rank symptoms?
Heinz A, Voss M, Lawrie SM, Mishara A, Bauer M, Gallinat J, Juckel G, Lang U, Rapp M, Falkai P, Strik W, Krystal J, Abi-Dargham A, Galderisi S. Shall we really say goodbye to first rank symptoms? European Psychiatry 2016, 37: 8-13. PMID: 27429167, DOI: 10.1016/j.eurpsy.2016.04.010.Peer-Reviewed Original ResearchDelusionsDiagnostic and Statistical Manual of Mental DisordersHumansInternational Classification of DiseasesMental DisordersPsychiatric Status Rating ScalesPsychopathologyPsychotic DisordersSchizophreniaSchizophrenic Psychology
2014
Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study.
Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2014, 76: 546-53. PMID: 25562376, DOI: 10.4088/jcp.14m09091.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiagnostic and Statistical Manual of Mental DisordersFactor Analysis, StatisticalFemaleHealth SurveysHumansMalePrevalenceResilience, PsychologicalStress Disorders, Post-TraumaticUnited StatesVeteransConceptsPosttraumatic stress disorderLifetime posttraumatic stress disorderHealth-related functioningMental health-related functioningDSM-5 posttraumatic stress disorderUS veteransSymptom clustersPTSD symptom clustersNational HealthVeterans StudyPTSD symptomsQuality of lifeDysphoric Arousal modelPosttraumatic stress disorder (PTSD) symptomsDSM-5 posttraumatic stress disorder symptomsDSM-5 PTSD symptom clustersHealth outcomesFemale veteransSuicidal ideationDSM-5 PTSD symptomsStress disorderSymptomsDisorder symptomsPTSD symptomatologyVeterans
2013
Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans
Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT, Krystal JH. Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Molecular Psychiatry 2013, 18: 1199-1204. PMID: 23337947, PMCID: PMC3646075, DOI: 10.1038/mp.2012.194.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingCerebral CortexDiagnostic and Statistical Manual of Mental DisordersExcitatory Amino Acid AntagonistsFemaleHealthy VolunteersHumansKetamineMaleMiddle AgedSchizophreniaConceptsFunctional connectivityNegative symptomsGamma-aminobutyric acid (GABA) neuronsNMDA receptor antagonist ketamineAspartate glutamate receptor antagonistContinuous ketamine infusionGlutamate receptor antagonistsNMDA-R antagonistsCortical functional connectivityNMDA-R antagonist ketamineSchizophrenia-like symptomsHealthy human subjectsNegative Syndrome ScaleBrain functional connectivityPrimary samplesRegion-specific mannerFunctional magnetic resonanceKetamine infusionReceptor antagonistPathological increaseSyndrome ScaleSymptomsPreclinical researchKetamineBrain oscillations
2011
New Frontiers in Animal Research of Psychiatric Illness
Kaffman A, Krystal J. New Frontiers in Animal Research of Psychiatric Illness. Methods In Molecular Biology 2011, 829: 3-30. PMID: 22231804, PMCID: PMC3337084, DOI: 10.1007/978-1-61779-458-2_1.Peer-Reviewed Original ResearchMeSH KeywordsAnimal ExperimentationAnimalsDiagnostic and Statistical Manual of Mental DisordersDisease Models, AnimalEndophenotypesHumansInternational Classification of DiseasesMental DisordersNervous SystemConceptsPsychiatric illnessAnimal modelsMental illnessHuman psychopathologyValid animal modelCurrent animal modelsNumerous psychiatric disordersMore effective interventionsResearch Domain Criteria projectInternational ClassificationPsychiatric disordersMeasurable endophenotypesIllnessNeurodevelopmental changesSubstance abuseEffective interventionsAnxiety disordersStatistical ManualMolecular changesDevelopmental originsMental disorders diagnostic systemsCircuit developmentTranslational workAnimal researchBehavioral outcomes
2007
Lamotrigine as Add-On Therapy in Schizophrenia
Goff DC, Keefe R, Citrome L, Davy K, Krystal JH, Large C, Thompson TR, Volavka J, Webster EL. Lamotrigine as Add-On Therapy in Schizophrenia. Journal Of Clinical Psychopharmacology 2007, 27: 582-589. PMID: 18004124, DOI: 10.1097/jcp.0b013e31815abf34.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsAntipsychotic AgentsClozapineDiagnostic and Statistical Manual of Mental DisordersDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleDrug ResistanceDrug Therapy, CombinationFemaleHumansLamotrigineMaleMiddle AgedPatient CompliancePatient DropoutsPsychiatric Status Rating ScalesSchizophreniaSeverity of Illness IndexSuicide, AttemptedTreatment OutcomeTriazinesConceptsNegative Syndrome Scale total scoreScale total scoreAntipsychotic medicationTotal scoreTreatment groupsSchizophrenia patientsPlacebo-controlled trialPrimary end pointParallel-group trialUse of lamotrigineClinical Global ImpressionAtypical antipsychotic medicationsResidual psychotic symptomsSymptom total scoreNegative Symptoms total scoreLamotrigine augmentationLamotrigine trialsRefractory psychosisAtypical antipsychoticsCognitive composite scoreWeek 12Global ImpressionTreat samplePsychotic symptomsLamotrigine
2006
Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study
Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study. Biological Psychiatry 2006, 59: 611-618. PMID: 16414030, DOI: 10.1016/j.biopsych.2005.08.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersDrug TherapyFemaleHumansMagnetic Resonance ImagingMalePeriodicityPrefrontal CortexConceptsHealthy comparison subjectsWhite matter volumeMagnetic resonance imagingMatter volumeBD patientsHigh-resolution structural magnetic resonance imagingYoung adulthoodStructural magnetic resonance imagingTotal brain volumeCross-sectional studyGray matter volumeAge group interactionVentral prefrontal cortexPharmacotherapy effectsPrefrontal cortex functionIllness featuresBD IProtective effectVolume abnormalitiesHC subjectsComparison subjectsBrain volumeVolume deficitsBipolar disorderRapid initial decline
2004
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, Krystal JH, Mason GF. Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression. JAMA Psychiatry 2004, 61: 705-713. PMID: 15237082, DOI: 10.1001/archpsyc.61.7.705.Peer-Reviewed Original ResearchMeSH KeywordsAdultAspartic AcidCholineDepressive DisorderDiagnostic and Statistical Manual of Mental DisordersFemaleGamma-Aminobutyric AcidGlutamic AcidGlutamineHumansMagnetic Resonance SpectroscopyMaleMiddle AgedOccipital LobePsychiatric Status Rating ScalesSeverity of Illness IndexConceptsMajor depressive disorderGamma-aminobutyric acidOccipital cortex GABA concentrationsProton magnetic resonance spectroscopyDepressed subjectsGABA concentrationHealthy controlsSubtypes of MDDCortical gamma-aminobutyric acidHealthy control subjectsMetabolite levelsCholine-containing compoundsHealthy comparison subjectsClinical research programSubtype-specific alterationsΓ-aminobutyric acidClinical correlatesMDD patientsControl subjectsDepressive disorderNeurotransmitter levelsGlutamate levelsMajor depressionMDD subtypesOccipital cortex