2011
Glutamatergic Modulation of Auditory Information Processing in the Human Brain
Gunduz-Bruce H, Reinhart RM, Roach BJ, Gueorguieva R, Oliver S, D'Souza DC, Ford JM, Krystal JH, Mathalon DH. Glutamatergic Modulation of Auditory Information Processing in the Human Brain. Biological Psychiatry 2011, 71: 969-977. PMID: 22036036, PMCID: PMC3290754, DOI: 10.1016/j.biopsych.2011.09.031.Peer-Reviewed Original ResearchConceptsN-acetylcysteineAuditory mismatch negativityReceptor antagonistN-methyl-D-aspartate receptor antagonistAspartate glutamate receptor antagonistOral N-acetylcysteinePlacebo-controlled studyGlutamate receptor antagonistsEffects of ketamineInfusion of salineMismatch negativityTest dayMMN amplitudeCystine-glutamate exchangerAuditory information processingP300 event-related potentialGlutamatergic modulationCognitive enhancing agentsEvent-related potentialsKetamine effectsHealthy volunteersHealthy humansSchizophrenia patientsPositive symptomsKetamine
2007
Neural Synchrony in Schizophrenia: From Networks to New Treatments
Ford JM, Krystal JH, Mathalon DH. Neural Synchrony in Schizophrenia: From Networks to New Treatments. Schizophrenia Bulletin 2007, 33: 848-852. PMID: 17567628, PMCID: PMC2632315, DOI: 10.1093/schbul/sbm062.Peer-Reviewed Original ResearchMeSH KeywordsBrainDopamineElectroencephalographyEvent-Related Potentials, P300HumansNerve NetReceptors, GABA-AReceptors, N-Methyl-D-AspartateSchizophreniaSignal TransductionConceptsBrain regionsNeural basisFunctional neuroanatomyNeural oscillationsTemporal synchronyNeural synchronyDifferent brain regionsNeural activityNeural assembliesNeural populationsCognitive dysfunctionDistinct neuronal populationsSchizophreniaTemporal domainPhasic relationshipSynaptic transmissionNeuronal populationsTranslational studiesNew treatmentsEmergent propertiesSynchronyNeural networkNeuroanatomyPsychosisNeurochemistry
2000
Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study
Boutros N, Reid M, Petrakis I, Campbell D, Torello M, Krystal J. Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study. International Psychogeriatrics 2000, 12: 513-525. PMID: 11263717, DOI: 10.1017/s1041610200006621.Peer-Reviewed Original ResearchConceptsInformation processingCortical information processingSensory gatingPaired-click paradigmOlder healthy subjectsAlcohol dependenceSensory gating deficitsStimulus classificationNovel stimuliOddball paradigmHealthy individualsYoung healthy groupEvoked potential studiesDSM-IV criteriaPotential studiesHealthy subjectsGender-matched groupAged healthy individualsGender-matched healthy individualsGating deficitsMiddle-aged individualsPsychotic symptomsOlder groupProcessingAlcoholic patients