2007
Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA‐Ar
Pittman B, Gueorguieva R, Krupitsky E, Rudenko AA, Flannery BA, Krystal JH. Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA‐Ar. Alcohol Clinical And Experimental Research 2007, 31: 612-618. PMID: 17374040, DOI: 10.1111/j.1530-0277.2007.00345.x.Peer-Reviewed Original ResearchConceptsAlcohol withdrawal syndromeCIWA-ArClinical Institute Withdrawal Assessment-AlcoholSymptom ChecklistCIWA-Ar scoresFirst study dayInpatient treatment unitAlcohol-dependent male inpatientsObserver-rated scalesAlcohol withdrawalWithdrawal syndromeTension/anxietyMale inpatientsIndependent factorsStudy daysClinical relevanceSelf-rating scaleAlcohol cravingObserver-rated measuresDiscriminative valueSelf-rated measuresInitial weeksAutonomic arousalFace validityResearch settings
1989
Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys
Krystal J, Walker M, Heninger G. Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys. European Journal Of Pharmacology 1989, 160: 331-338. PMID: 2540995, DOI: 10.1016/0014-2999(89)90088-5.Peer-Reviewed Original ResearchConceptsOpiate withdrawal syndromeInjection of naloxoneWithdrawal syndromeTreatment periodNaloxone injectionNaloxone administrationWithdrawal responsePhysical dependenceDays of methadoneAntagonist exposureMethadone treatmentDaily injectionsLack of incrementReceptor mechanismsDrug combinationsNaloxoneRhesus monkeysSyndromeDay 16MethadoneSame monkeysManagement of situationsInjectionAdministrationDays