2008
Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence
Martinez D, Slifstein M, Gil R, Hwang DR, Huang Y, Perez A, Frankle WG, Laruelle M, Krystal J, Abi-Dargham A. Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence. Biological Psychiatry 2008, 65: 175-180. PMID: 18962444, PMCID: PMC2621104, DOI: 10.1016/j.biopsych.2008.08.034.Peer-Reviewed Original ResearchConceptsType II alcoholismSerotonergic transmissionControl subjectsTransporter levelsAlcohol-dependent subjectsNonspecific partition coefficientEmission Tomography ImagingPositron emission tomography (PET) imagingSeverity of alcoholismDifferent brain regionsTwo-tissue compartment modelSerotonin innervationTransporter availabilityAlcoholic subjectsRodent modelsAlcohol dependenceDisease severitySignificant negative correlationBrain regionsSerotonin transporterSubjects SubjectsAlcoholismTomography imagingSignificant differencesPatients
1998
Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil
Abi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil. American Journal Of Psychiatry 1998, 155: 1550-1555. PMID: 9812116, DOI: 10.1176/ajp.155.11.1550.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsBenzodiazepine receptorsComparison subjectsAlcoholic subjectsDistribution volumeAlcoholic patientsAnterior cingulateBenzodiazepine receptor densityRight middle frontal gyrusLeft occipital cortexType II alcoholismSingle photon emissionMiddle frontal gyrusStatistical parametric mappingContinuous infusionReceptor radiotracerReceptor densityOccipital cortexCerebellar cortexCortical regionsPatientsFrontal gyrusInterest analysisVivo studiesParametric mapping