2019
Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study
Tamman AJF, Montalvo-Ortiz JL, Southwick SM, Krystal JH, Levy BR, Pietrzak RH. Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2019, 27: 528-532. PMID: 30792041, DOI: 10.1016/j.jagp.2019.01.001.Peer-Reviewed Original ResearchConceptsNational HealthPsychosocial factorsVeterans StudyMale U.S. veteransLifetime trauma burdenAccelerated DNA methylation agingDNA methylation agingU.S. military veteransMethylation agingTrauma burdenU.S. veteransPrevention effortsAdditional correlatesNegative beliefsMilitary veteransSexual traumaVeteransTraumatic stressDNA methylationHealthChild sexual traumaBody massRepresentative sample
2015
Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress
Licznerski P, Duric V, Banasr M, Alavian KN, Ota KT, Kang HJ, Jonas EA, Ursano R, Krystal JH, Duman RS, . Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. PLOS Biology 2015, 13: e1002282. PMID: 26506154, PMCID: PMC4623974, DOI: 10.1371/journal.pbio.1002282.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBehavior, AnimalCohort StudiesDendritic SpinesDepressive Disorder, MajorEnzyme RepressionFemaleGene Transfer TechniquesHippocampusHumansImmediate-Early ProteinsMaleMiddle AgedNerve Tissue ProteinsNeuronsPrefrontal CortexProtein Serine-Threonine KinasesRats, Sprague-DawleySignal TransductionStress Disorders, Post-TraumaticSynaptic TransmissionTissue BanksConceptsMajor depressive disorderPost-traumatic stress disorderPrefrontal cortexAbnormal dendritic spine morphologyCorticolimbic brain regionsAnhedonic-like behaviorInhibition of SGK1Dendritic spine morphologyKinase 1 expressionAmygdala of individualsTraumatic stressPostmortem prefrontal cortexSynaptic dysfunctionDepressive disorderBehavioral deficitsRodent modelsPTSD subjectsFunctional alterationsBrain regionsSGK1 expressionSpine morphologyStress disorderFunction contributesBehavioral changesDisorders
1995
Functional neuroanatomical correlates of the effects of stress on memory
Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. DOI: 10.1007/bf02102888.Peer-Reviewed Original ResearchPosttraumatic stress disorderEffects of stressBrain regionsTraumatic stressNeural mechanismsSymptoms of PTSDFalse memory syndromeFunctional neuroanatomical correlatesFear conditioningNeurobiological approachStress disorderDissociative amnesiaMemory syndromeStress sensitizationNeuroanatomical correlatesMemory functionChildhood memoriesMemoryStress-induced alterationsImplicationsAmnesiaPsychotherapyCorrelatesConditioningSymptomsFunctional neuroanatomical correlates of the effects of stress on memory
Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. PMID: 8564272, DOI: 10.1002/jts.2490080403.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderEffects of stressBrain regionsTraumatic stressNeural mechanismsSymptoms of PTSDFalse memory syndromeFunctional neuroanatomical correlatesFear conditioningNeurobiological approachStress disorderDissociative amnesiaMemory syndromeStress sensitizationNeuroanatomical correlatesMemory functionChildhood memoriesMemoryStress-induced alterationsImplicationsAmnesiaPsychotherapyCorrelatesConditioningSymptoms
1985
Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stress
van der Kolk B, Greenberg M, Boyd H, Krystal J. Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stress. Biological Psychiatry 1985, 20: 314-325. PMID: 2858226, DOI: 10.1016/0006-3223(85)90061-7.Peer-Reviewed Original ResearchConceptsPost-traumatic stressStress-induced analgesiaTraumatic stressInescapable shockChronic post-traumatic stressCatecholamine depletionMassive psychic traumaEndogenous opioid releasePhysiological hyperreactivityTraumatized individualsPsychic traumaBehavioral sequelaeOpioid withdrawalPsychodynamic conceptsEndogenous opioidsPsychosocial meaningOpioid releaseMental disordersTraumaPhysiological componentsReexposureHuman equivalentAnalgesiaHyperreactivityAnimals