2007
Psychiatric safety of ketamine in psychopharmacology research
Perry EB, Cramer JA, Cho HS, Petrakis IL, Karper LP, Genovese A, O’Donnell E, Krystal JH, D’Souza D. Psychiatric safety of ketamine in psychopharmacology research. Psychopharmacology 2007, 192: 253-260. PMID: 17458544, DOI: 10.1007/s00213-007-0706-2.Peer-Reviewed Original ResearchConceptsSubanesthetic dosesHealthy human subjectsKetamine administrationClinical research programHuman subjectsTest sessionsPsychotic spectrum disordersPsychiatric safetyResidual sequelaePlacebo infusionIntravenous infusionKetamine effectsPsychopharmacology studiesResultsFour hundredAdverse reactionsObjectiveTo reportHealthy subjectsStudy participationClinical investigationHealthy humansSide effectsKetamineInfusionDosesAdministration
2002
The Effect of Tryptophan Depletion on Alcohol Self‐Administration in Non‐Treatment‐Seeking Alcoholic Individuals
Petrakis IL, Buonopane A, O'Malley S, Cermik O, Trevisan L, Boutros NN, Limoncelli D, Krystal JH. The Effect of Tryptophan Depletion on Alcohol Self‐Administration in Non‐Treatment‐Seeking Alcoholic Individuals. Alcohol Clinical And Experimental Research 2002, 26: 969-975. PMID: 12170105, DOI: 10.1111/j.1530-0277.2002.tb02629.x.Peer-Reviewed Original ResearchConceptsTest sessionsActive tryptophan depletionSelf-reported cravingTryptophan depletionFavorite alcoholic beverageCue exposure sessionsAmount of alcoholAmino acid drinkSelf-administration paradigmAlcohol-dependent individualsAlcohol Self-AdministrationAlcohol use disorderDependence of alcoholNeurobiological mechanismsExposure sessionsSubjective intoxicationBlood alcohol levelsPriming drinkAlcohol useAcid drinkUse disordersAlcoholic individualsAlcohol dependenceCravingTest day
1997
Lack of behavioral effects of monoamine depletion in healthy subjects
Salomon R, Miller H, Krystal J, Heninger G, Charney D. Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry 1997, 41: 58-64. PMID: 8988796, DOI: 10.1016/0006-3223(95)00670-2.Peer-Reviewed Original ResearchConceptsAmino acid drinkHealthy subjectsAcid drinkTryptophan-free amino acid drinkBehavioral effectsTyrosine hydroxylase inhibitorTest sessionsMonoamine depletionMonoamine hypothesisPara-tyrosineCombined administrationAlpha-methylHydroxylase inhibitorDrinksSubjectsSessionsAMPTCatecholaminesAdministration
1995
Tryptophan depletion and attenuation of cue-induced craving for cocaine
Satel SL, Krystal JH, Delgado PL, Kosten TR, Charney DS. Tryptophan depletion and attenuation of cue-induced craving for cocaine. American Journal Of Psychiatry 1995, 152: 778-783. PMID: 7726319, DOI: 10.1176/ajp.152.5.778.Peer-Reviewed Original ResearchConceptsCue-induced cravingTryptophan depletionPlacebo conditionPotent serotonin reuptake blockerCue exposureSerotonin reuptake blockersDouble-blind designAmino acid drinkVisual analogue ratingsCocaine-dependent patientsAnalogue ratingsReuptake blockerAcute reductionPlasma levelsSerotonergic systemMale inpatientsAcid drinkTryptophan levelsDrug usePatientsCocaine useCocaineRelapseCravingTest sessions