2011
Noradrenergic vs Serotonergic Antidepressant with or without Naltrexone for Veterans with PTSD and Comorbid Alcohol Dependence
Petrakis IL, Ralevski E, Desai N, Trevisan L, Gueorguieva R, Rounsaville B, Krystal JH. Noradrenergic vs Serotonergic Antidepressant with or without Naltrexone for Veterans with PTSD and Comorbid Alcohol Dependence. Neuropsychopharmacology 2011, 37: 996-1004. PMID: 22089316, PMCID: PMC3280636, DOI: 10.1038/npp.2011.283.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderSerotonin uptake inhibitorNorepinephrine uptake inhibitorUptake inhibitorAlcohol dependenceMale veteransTreatment of PTSDUse outcomesSymptoms of PTSDDouble-blind conditionsMain outcome measuresEvidence of efficacyComorbid alcohol dependenceCurrent diagnostic criteriaAlcohol use disorderAlcohol use outcomesComorbid conditionsAdjunctive efficacyOutcome measuresOnly FDADiagnostic criteriaUse disordersClinical advantagesAlcohol consumptionDrug Administration
2009
Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience
Krystal JH, Neumeister A. Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience. Brain Research 2009, 1293: 13-23. PMID: 19332037, PMCID: PMC2761677, DOI: 10.1016/j.brainres.2009.03.044.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderOrdinary stressful life eventsEtiology of PTSDNeurobiology of PTSDSymptoms of PTSDImpact of traumaStressful life eventsTraumatic eventsNeurobiological systemsLife eventsTreatment developmentSerotonergic mechanismsNeurobiologyUse of antidepressantsDevelopment of treatmentsBasic researchResilienceMonoaminergic mechanismsAvailable treatmentsRelevant findingsHyperarousalResearchDisordersPsychopathology
1995
Functional neuroanatomical correlates of the effects of stress on memory
Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. DOI: 10.1007/bf02102888.Peer-Reviewed Original ResearchPosttraumatic stress disorderEffects of stressBrain regionsTraumatic stressNeural mechanismsSymptoms of PTSDFalse memory syndromeFunctional neuroanatomical correlatesFear conditioningNeurobiological approachStress disorderDissociative amnesiaMemory syndromeStress sensitizationNeuroanatomical correlatesMemory functionChildhood memoriesMemoryStress-induced alterationsImplicationsAmnesiaPsychotherapyCorrelatesConditioningSymptomsFunctional neuroanatomical correlates of the effects of stress on memory
Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. PMID: 8564272, DOI: 10.1002/jts.2490080403.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderEffects of stressBrain regionsTraumatic stressNeural mechanismsSymptoms of PTSDFalse memory syndromeFunctional neuroanatomical correlatesFear conditioningNeurobiological approachStress disorderDissociative amnesiaMemory syndromeStress sensitizationNeuroanatomical correlatesMemory functionChildhood memoriesMemoryStress-induced alterationsImplicationsAmnesiaPsychotherapyCorrelatesConditioningSymptoms