2021
Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans
Na PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans. Molecular Psychiatry 2021, 27: 1068-1074. PMID: 34725455, DOI: 10.1038/s41380-021-01352-2.Peer-Reviewed Original ResearchConceptsNew-onset suicidal ideationChronic suicidal ideationPolygenic risk scoresSuicidal ideationProspective cohort studyPolygenic riskRisk of SIHigher baseline levelsHigh polygenic riskModifiable psychosocial factorsSocial supportDispositional optimismCohort studyProspective cohortUS veteransSymptomatic courseRisk scorePsychosocial factorsGenome-wide association studiesBaseline levelsU.S. veteransSuicidal thoughtsPsychosocial moderatorsStudy periodLarge genome-wide association studies
2020
Predictors and correlates of lifetime and persistent non-suicidal self-injury and suicide attempts among adult survivors of childhood sexual abuse
Steine IM, Nielsen B, Porter PA, Krystal JH, Winje D, Grønli J, Milde AM, Bjorvatn B, Nordhus IH, Pallesen S. Predictors and correlates of lifetime and persistent non-suicidal self-injury and suicide attempts among adult survivors of childhood sexual abuse. European Journal Of Psychotraumatology 2020, 11: 1815282. PMID: 33312451, PMCID: PMC7717684, DOI: 10.1080/20008198.2020.1815282.Peer-Reviewed Original ResearchAdult CSA survivorsChildhood sexual abuseCSA survivorsSexual abuseProximal factorsPredictors of NSSISexual abuse survivorsSuicide attemptsMental health symptomsNew suicide attemptSocial support scoresIndividual differencesAbuse survivorsMental health disordersRelational problemsDistal factorsHealth symptomsNSSIChildhood maltreatmentProblem scoresHigher depressionSocial supportPast suicide attemptsForm of symptomsLifetime NSSILongitudinal Relationships between Perceived Social Support and Symptom Outcomes: Findings from a sample of Adult Survivors of Childhood Sexual Abuse
Steine IM, Winje D, Krystal JH, Milde AM, Bjorvatn B, Nordhus IH, Grønli J, Pallesen S. Longitudinal Relationships between Perceived Social Support and Symptom Outcomes: Findings from a sample of Adult Survivors of Childhood Sexual Abuse. Child Abuse & Neglect 2020, 107: 104566. PMID: 32526550, DOI: 10.1016/j.chiabu.2020.104566.Peer-Reviewed Original ResearchConceptsChildhood sexual abuseMental health symptomsCSA survivorsSocial supportRelational problemsSexual abuseHealth symptomsCross-lagged panel analysisAdult survivorsAdult CSA survivorsPosttraumatic stress symptomsSexual abuse survivorsFemale CSA survivorsLongitudinal studyPerceived Social SupportFour-year longitudinal studyDifferent symptom domainsPosttraumatic stressAbuse survivorsStress symptomsAnxiety symptomsReciprocal associationsLongitudinal relationshipLongitudinal associationsSymptom domains
2018
Trajectories of alcohol consumption in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Fuehrlein BS, Kachadourian LK, DeVylder EK, Trevisan LA, Potenza MN, Krystal JH, Southwick SM, Pietrzak RH. Trajectories of alcohol consumption in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. American Journal On Addictions 2018, 27: 383-390. PMID: 29667712, DOI: 10.1111/ajad.12731.Peer-Reviewed Original ResearchMajor depressive disorderLifetime major depressive disorderAlcohol consumptionPredominant trajectoriesNational HealthVeterans StudyAlcohol Use Disorders Identification Test-ConsumptionBrief alcohol screensExcessive drinkingPopulation-based preventionSocial supportExcessive alcohol consumptionAlcohol use disorderLow social supportU.S. military veteransAlcohol screenBaseline determinantsDepressive disorderLatent growth mixture modelingMedical conditionsModerate drinkersRare drinkersModerate drinkingUse disordersGreater social support
2017
Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Mota NP, Han S, Harpaz‐Rotem I, Maruff P, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2017, 35: 168-177. PMID: 29172227, PMCID: PMC5794529, DOI: 10.1002/da.22698.Peer-Reviewed Original ResearchConceptsΕ4 allele carriersApolipoprotein E gene polymorphismE gene polymorphismTrauma burdenU.S. military veteransAllele carriersPosttraumatic stress disorderPTSD symptomsNational HealthGreater social supportGene polymorphismsGreater severityMilitary veteransVeterans StudyAPOE ε4 carrier statusSocial supportΕ4 carrier statusAPOE genotypeΕ4 noncarriersPosttraumatic stress symptomsIndependent replication sampleSymptomsPTSD riskStress disorderCarrier statusPosttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study
Steine IM, Winje D, Skogen JC, Krystal JH, Milde AM, Bjorvatn B, Nordhus IH, Grønli J, Pallesen S. Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study. Child Abuse & Neglect 2017, 67: 280-293. PMID: 28327414, DOI: 10.1016/j.chiabu.2017.03.002.Peer-Reviewed Original ResearchConceptsChildhood sexual abuseSexual abuseAdult survivorsPosttraumatic Stress Symptom TrajectoriesSexual abuse survivorsClinical-level symptomsLatent profile analysisAbuse survivorsRelational difficultiesAbusive experiencesPTSS trajectoriesPenetrative abusePTSSChildhood maltreatmentBest overall fitSocial supportIntense anxietyNorwegian sampleBiological parentsLongitudinal studySymptom trajectoriesClinical interventionsSymptom profilesAbuseOverall fitCumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse
Steine IM, Winje D, Krystal JH, Bjorvatn B, Milde AM, Grønli J, Nordhus IH, Pallesen S. Cumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse. Child Abuse & Neglect 2017, 65: 99-111. PMID: 28131947, DOI: 10.1016/j.chiabu.2017.01.008.Peer-Reviewed Original ResearchConceptsCumulative childhood maltreatmentChildhood maltreatmentPosttraumatic stressSexual abuseSocial supportChildhood adversityAdult survivorsRule-governed wayHierarchical regression analysisChildhood maltreatment experiencesSelf-harm behaviorsDose-response relationCumulative childhood adversityAdult symptomatologyDisorder symptomsSelf-reported symptomsPsychological distressRelational problemsSymptom complexityMaltreatment experiencesWork functioningEmotional painRelated distressMaltreatment scoresAdversity
2011
Insomnia, Nightmare Frequency, and Nightmare Distress in Victims of Sexual Abuse
Steine IM, Krystal JH, Nordhus IH, Bjorvatn B, Harvey AG, Eid J, Grønli J, Milde AM, Pallesen S. Insomnia, Nightmare Frequency, and Nightmare Distress in Victims of Sexual Abuse. Journal Of Interpersonal Violence 2011, 27: 1827-1843. PMID: 22204947, DOI: 10.1177/0886260511430385.Peer-Reviewed Original Research
2006
Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children
Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children. Biological Psychiatry 2006, 59: 673-680. PMID: 16458264, DOI: 10.1016/j.biopsych.2005.10.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrain-Derived Neurotrophic FactorCase-Control StudiesChildChild AbuseChild, PreschoolChi-Square DistributionDepressionDNA Mutational AnalysisEnvironmentFemaleGene FrequencyGenetic VariationGenotypeHumansMaleMethioninePredictive Value of TestsPsychiatric Status Rating ScalesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSeverity of Illness IndexSocial SupportSurveys and QuestionnairesValineConceptsBrain-derived neurotrophic factor (BDNF) genotypeNeurotrophic factor genotypeSocial supportHigher depression scoresBDNF genotypeProportion scoreBDNF geneProtective effectDepression scoresComparison subjectsPsychiatric symptomatologyModerate riskEnvironmental modifiersDepressionFactor genotypeChildrenDNA specimensStandard research instrumentsShort alleleRiskMaltreatment historyCurrent dataScoresAncestry informative markersChild abuse
2004
Social supports and serotonin transporter gene moderate depression in maltreated children
Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 17316-17321. PMID: 15563601, PMCID: PMC534414, DOI: 10.1073/pnas.0404376101.Peer-Reviewed Original ResearchConceptsSocial supportDevelopment of depressionGene promoter polymorphismTransporter gene promoter polymorphismSerotonin transporter gene promoter polymorphismHigher depression ratingsDepression ratingsClinical dataModerate depressionPsychiatric disordersDepression scoresPromoter polymorphismNegative sequelaeModerate riskDepressionEarly stressChildrenS genotypeHistory of maltreatmentRiskShort allele