2023
A computational model for learning from repeated traumatic experiences under uncertainty
Kaye A, Rao M, Kwan A, Ressler K, Krystal J. A computational model for learning from repeated traumatic experiences under uncertainty. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 894-904. PMID: 37165181, PMCID: PMC11149767, DOI: 10.3758/s13415-023-01085-5.Peer-Reviewed Original ResearchPosttraumatic stress disorderTraumatic eventsNovel contextThreat perceptionTreatment of PTSDEarly life traumaNeutral cuesThreat responsesStress disorderLife traumaTraumatic experiencesPrediction errorComputational theorySensory cuesPTSD incidenceNovel predictionsUnpredictable footshockInternal statesComputational modelCuesPerceptionSpecific associationFootshockContextTheory
2020
Predictive Processing in Mental Illness: Hierarchical Circuitry for Perception and Trauma
Kaye AP, Krystal JH. Predictive Processing in Mental Illness: Hierarchical Circuitry for Perception and Trauma. Journal Of Psychopathology And Clinical Science 2020, 129: 629-632. PMID: 32757606, DOI: 10.1037/abn0000628.Peer-Reviewed Original ResearchConceptsTrauma-related disordersPredictive processingDisorders of perceptionNeural circuitsHigher-order predictionsAbnormal psychologyPrediction errorSensory stimuliPredictive codingHierarchical circuitryPrior beliefsNew sensory dataPerceptionBayesian processPsychiatric disordersPsychotic disordersHierarchical viewHierarchical organizationMental illnessSensory dataBeliefsDisordersFuture directionsComputational layerProcessing
2016
Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology
Abdallah CG, Averill LA, Krystal JH, Southwick SM, Arnsten AF. Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology. Behavioral And Brain Sciences 2016, 39: e201. PMID: 28347382, PMCID: PMC5485236, DOI: 10.1017/s0140525x15001727.Peer-Reviewed Original Research
2010
Toward a neurobiology of delusions
Corlett PR, Taylor JR, Wang X, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Progress In Neurobiology 2010, 92: 345-369. PMID: 20558235, PMCID: PMC3676875, DOI: 10.1016/j.pneurobio.2010.06.007.Peer-Reviewed Original ResearchConceptsFundamental brain mechanismsFronto-striatal circuitsTerms of cognitionPsychological processesBrain mechanismsComputational mechanismsCortical hierarchyPrediction errorSocial learningParietal cortexExternal worldBrain circuitsNeurobiological abnormalitiesNeurobiology of delusionsBrain functionHierarchical predictionBodily agencyDelusionsMemoryReinforcement learningPerceptionMental illnessTranslational understandingLearningCognition
2009
Illusions and Delusions: Relating Experimentally-Induced False Memories to Anomalous Experiences and Ideas
Corlett PR, Simons JS, Pigott JS, Gardner JM, Murray GK, Krystal JH, Fletcher PC. Illusions and Delusions: Relating Experimentally-Induced False Memories to Anomalous Experiences and Ideas. Frontiers In Behavioral Neuroscience 2009, 3: 53. PMID: 19956402, PMCID: PMC2786301, DOI: 10.3389/neuro.08.053.2009.Peer-Reviewed Original ResearchSalience hypothesisMemory illusionsCognitive underpinningsDeese-RoedigerFalse memoriesPrevious stimuliAnomalous experiencesSalience modelMagical thinkingBelief formationIllusionStimuliUnpredictable experienceTheoretical importanceMemoryPerceptionExperiencePsychosisCognitionFluencySalienceAttributionHypothesisMcDermottFamiliarity
2000
The Emerging Neurobiology of Dissociative States
Krystal J, Bremner J, D’Souza D, Anand A, Southwick S, Charney D. The Emerging Neurobiology of Dissociative States. Springer Series On Stress And Coping 2000, 307-320. DOI: 10.1007/978-1-4615-4177-6_22.Peer-Reviewed Original ResearchPerceptual alterationsFocusing of attentionCognitive processesDistorts perceptionsPerceptual distortionReduced processingInformation processingPeripheral stimuliProlonged sensory deprivationSensory perceptionSensory deprivationPerceptionEveryday lifeDissociative statesExact transcriptionProcessingDepersonalizationMemoryIllusionNeurobiologyStimuliDerealizationHallucinationsAttentionPeople
1996
Recent Developments in the Neurobiology of Dissociation
Krystal J, Bennett A, Bremner J, Southwick S, Charney D. Recent Developments in the Neurobiology of Dissociation. 1996, 163-190. DOI: 10.1007/978-1-4899-0310-5_8.Peer-Reviewed Original ResearchPost-traumatic stress disorderTraumatic stress responseDissociative statesTime perceptionTerm dissociationStress disorderSingle symptom clusterSubjective experienceSymptom clustersSensory perceptionFugue statesMultiple personalityConversion symptomsPerceptionIdentity functionBroad arrayDepersonalizationParticular symptomsMemoryPersonalitySymptomsAmnesiaNeurobiologyDerealizationIndividuals