2023
A computational model for learning from repeated traumatic experiences under uncertainty
Kaye A, Rao M, Kwan A, Ressler K, Krystal J. A computational model for learning from repeated traumatic experiences under uncertainty. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 894-904. PMID: 37165181, PMCID: PMC11149767, DOI: 10.3758/s13415-023-01085-5.Peer-Reviewed Original ResearchPosttraumatic stress disorderTraumatic eventsNovel contextThreat perceptionTreatment of PTSDEarly life traumaNeutral cuesThreat responsesStress disorderLife traumaTraumatic experiencesPrediction errorComputational theorySensory cuesPTSD incidenceNovel predictionsUnpredictable footshockInternal statesComputational modelCuesPerceptionSpecific associationFootshockContextTheory
2020
Drinking and responses to antidrinking messages among young adults: An fMRI study
Garrison KA, DeMartini KS, Corlett PR, Worhunsky PD, Krystal JH, O'Malley SS. Drinking and responses to antidrinking messages among young adults: An fMRI study. Addiction Biology 2020, 26: e12882. PMID: 32068323, PMCID: PMC7431375, DOI: 10.1111/adb.12882.Peer-Reviewed Original ResearchConceptsDrinking cuesNeural responsesYoung adultsFunctional magnetic resonanceSelf-reported drinkingPast monthNeutral cuesDrug cuesSmoking cuesHabitual responsesReward processingFMRI studyDrinking quantityCuesDependent individualsSubstance useAlcohol useBinge drinkingNegative consequencesGreater baselinePublic health campaignsExcessive drinkingHeavy drinkingHealth campaignsDrinking
2018
Alcohol Expectancy and Cerebral Responses to Cue-Elicited Craving in Adult Nondependent Drinkers
Zhornitsky S, Zhang S, Ide JS, Chao HH, Wang W, Le TM, Leeman RF, Bi J, Krystal JH, Li CR. Alcohol Expectancy and Cerebral Responses to Cue-Elicited Craving in Adult Nondependent Drinkers. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 4: 493-504. PMID: 30711509, PMCID: PMC6500759, DOI: 10.1016/j.bpsc.2018.11.012.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification Test (AUDIT) scoresFrontal cortical connectivityCerebral responsesCortical connectivityPositive scoreAlcohol cuesNondependent drinkersAlcohol Use Disorders Identification TestLeft caudate headCue activityCue responsesAlcohol expectanciesProblem drinkingDisorders Identification TestNeutral cuesMedial orbitofrontal cortexAlcohol Expectancy QuestionnaireFunctional magnetic resonanceBilateral thalamusThalamic processingCaudate headRisk drinkingThalamic responsesRed nucleusImaging studies