1992
Baclofen-assisted detoxification from opiates A pilot study
Krystal J, McDougle C, Kosten T, Price L, Aghajanian G, Charney D. Baclofen-assisted detoxification from opiates A pilot study. Journal Of Substance Use And Addiction Treatment 1992, 9: 139-142. PMID: 1324986, DOI: 10.1016/0740-5472(92)90081-x.Peer-Reviewed Original ResearchConceptsOpen-label pilot studyPilot studyLabel pilot studyOpiate-dependent patientsAbrupt discontinuationOral dosesOpiate detoxificationAdjunctive rolePrimary treatmentOpiate dependencePatientsBaclofenInsufficient suppressionDose rangeMyalgiaVomitingClonidineDiscontinuationMedicationsHeadacheMethadoneDetoxificationDoses
1989
Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys
Krystal J, Walker M, Heninger G. Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys. European Journal Of Pharmacology 1989, 160: 331-338. PMID: 2540995, DOI: 10.1016/0014-2999(89)90088-5.Peer-Reviewed Original ResearchConceptsOpiate withdrawal syndromeInjection of naloxoneWithdrawal syndromeTreatment periodNaloxone injectionNaloxone administrationWithdrawal responsePhysical dependenceDays of methadoneAntagonist exposureMethadone treatmentDaily injectionsLack of incrementReceptor mechanismsDrug combinationsNaloxoneRhesus monkeysSyndromeDay 16MethadoneSame monkeysManagement of situationsInjectionAdministrationDays