2005
Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder
Blumberg HP, Donegan NH, Sanislow CA, Collins S, Lacadie C, Skudlarski P, Gueorguieva R, Fulbright RK, McGlashan TH, Gore JC, Krystal JH. Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology 2005, 183: 308-313. PMID: 16249909, DOI: 10.1007/s00213-005-0156-7.Peer-Reviewed Original ResearchConceptsUnmedicated bipolar disorderMood-stabilizing medicationsBipolar disorderBD participantsPotential treatment targetMagnetic resonance imagingPreliminary evidenceMethodsFunctional magnetic resonance imagingAnterior cingulate activationResultsThe groupMedication effectsFunctional abnormalitiesHealthy comparison participantsObjectivesThe aimAnterior cingulateTreatment targetsResonance imagingMedicationsHC participantsAmygdala activationCingulate activationAmygdala increasesComparison participantsEmotional stimuliAbnormalities
1992
Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine
Krystal J, McDougle C, Woods S, Price L, Heninger G, Charney D. Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine. Psychopharmacology 1992, 108: 313-319. PMID: 1355923, DOI: 10.1007/bf02245117.Peer-Reviewed Original ResearchConceptsHealthy subjectsDiastolic blood pressureΑ2-adrenergic receptorsSymptom scale scoresHealthy human subjectsDose-response relationshipIdazoxan doseBlood pressureOral yohimbineNorepinephrine metabolitePlasma levelsMedication effectsOral administrationPlasma MHPGPhysiologic indicesNeuroendocrine responsesΑ2 antagonistAdrenergic receptorsCortisol levelsScale scorePlasma cortisolYohimbineIdazoxanAnxiety statesReceptor specificity