2003
Toward early pharmacological posttraumatic stress intervention
Morgan CA, Krystal JH, Southwick SM. Toward early pharmacological posttraumatic stress intervention. Biological Psychiatry 2003, 53: 834-843. PMID: 12725976, DOI: 10.1016/s0006-3223(03)00116-1.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderExtreme psychological traumaStress-related symptomsIntrusive memoriesPsychological processingExtreme arousalTrauma survivorsPsychological traumaStress disorderStress interventionsAcute aftermathExtreme stressPharmacologic interventionsAdaptive roleEffective pharmacologic interventionsPotential pharmacologic interventionsInterventionTransient symptomsImmediate aftermathArousalEmpirical dataEarly symptomsMemorySymptomsTrauma
1999
Neurotransmitter alterations in PTSD: catecholamines and serotonin.
Southwick SM, Paige S, Morgan CA, Bremner JD, Krystal JH, Charney DS. Neurotransmitter alterations in PTSD: catecholamines and serotonin. Seminars In Clinical Neuropsychiatry 1999, 4: 242-8. PMID: 10553029, DOI: 10.153/scnp00400242.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderIntrusive memoriesLevel of alertnessSelective attentionAuditory remindersLife-threatening stimuliStress disorderCatecholamine dysregulationUrine catecholamine excretionExaggerated reactivityDepressed moodExaggerated startlePlatelet paroxetine bindingSerotonergic dysregulationAggressionClinical efficacyImpulsivityMotor outputBlunted prolactin responseMemoryMoodSerotonin reuptake inhibitorsAdrenergic receptor numberCentral catecholamine neuronsCentral nervous system