Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers
Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.Peer-Reviewed Original ResearchConceptsSkin conductance responsesPhysiological arousalThalamic activityNeural processesNeutral cue exposureMediation analysisHigher skin conductance responsesCue exposure paradigmCue-related activationsCue-elicited cravingCue-elicited drugNon-dependent drinkersImportant sex differencesSkin conductance dataPharmacological therapyAlcohol drinkersNeural targetsAlcohol cravingExposure paradigmCue exposureNeural correlatesNeural basisConductance responsesWomenCue activityAltered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments
Duman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron 2019, 102: 75-90. PMID: 30946828, PMCID: PMC6450409, DOI: 10.1016/j.neuron.2019.03.013.Peer-Reviewed Original ResearchConceptsAltered connectivityDepressed patientsExcitatory glutamate neuronsMajor neuronal typesRapid-acting agentsAtrophy of neuronsTreatment of depressionLimbic brain regionsChronic stress exposureStress-related disordersBrain imaging studiesImportant sex differencesNeurotransmitter deficitsGABA interneuronsImmunologic mechanismsGlutamate neuronsCurrent antidepressantsExcitotoxic effectsNeurochemical deficitsGlutamate dysfunctionPathophysiological mechanismsGABA systemInflammatory cytokinesAdrenal glucocorticoidsHippocampal region