2007
Probing the Pathophysiology of Auditory/Verbal Hallucinations by Combining Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation
Hoffman RE, Hampson M, Wu K, Anderson AW, Gore JC, Buchanan RJ, Constable RT, Hawkins KA, Sahay N, Krystal JH. Probing the Pathophysiology of Auditory/Verbal Hallucinations by Combining Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation. Cerebral Cortex 2007, 17: 2733-2743. PMID: 17298962, PMCID: PMC2634833, DOI: 10.1093/cercor/bhl183.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationTranscranial magnetic stimulationFunctional magnetic resonance imagingMagnetic resonance imagingMagnetic stimulationSham stimulationTemporoparietal repetitive transcranial magnetic stimulationAuditory/verbal hallucinationsResonance imagingWernicke's areaVerbal hallucinationsBOLD signal time coursesBroca's areaSchizophrenia spectrum disordersGreater rateInferior frontal regionsPatientsTemporoparietal areasSignal time courseCortical sitesPathophysiologySupramarginal gyrusHallucinationsRight homologueStimulation
2005
Temporoparietal Transcranial Magnetic Stimulation for Auditory Hallucinations: Safety, Efficacy and Moderators in a Fifty Patient Sample
Hoffman RE, Gueorguieva R, Hawkins KA, Varanko M, Boutros NN, Wu YT, Carroll K, Krystal JH. Temporoparietal Transcranial Magnetic Stimulation for Auditory Hallucinations: Safety, Efficacy and Moderators in a Fifty Patient Sample. Biological Psychiatry 2005, 58: 97-104. PMID: 15936729, DOI: 10.1016/j.biopsych.2005.03.041.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationTranscranial magnetic stimulationAuditory hallucinationsSham stimulationMagnetic stimulationTemporoparietal repetitive transcranial magnetic stimulationClinical Global Impression ScaleGlobal Impression ScaleRight-handed patientsMotor thresholdImpression ScaleRTMS effectsNew patientsNeurocognitive impairmentHallucination frequencySchizoaffective disorderPatient samplesSignificant distressPatientsChange scoresHallucinationsPreliminary reportStimulationNeurobiological factorsIntervention
2004
Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia
Hoffman R, Mathalon D, Ford J, Krystal J. Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia. Behavioral And Brain Sciences 2004, 27: 797-798. DOI: 10.1017/s0140525x04320182.Peer-Reviewed Original Research
2003
Transcranial Magnetic Stimulation of Left Temporoparietal Cortex and Medication-Resistant Auditory Hallucinations
Hoffman RE, Hawkins KA, Gueorguieva R, Boutros NN, Rachid F, Carroll K, Krystal JH. Transcranial Magnetic Stimulation of Left Temporoparietal Cortex and Medication-Resistant Auditory Hallucinations. JAMA Psychiatry 2003, 60: 49-56. PMID: 12511172, DOI: 10.1001/archpsyc.60.1.49.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationMedication-resistant auditory hallucinationsTranscranial magnetic stimulationLeft temporoparietal cortexAuditory hallucinationsSham stimulationMagnetic stimulationTemporoparietal cortexOpen-label trialMotor thresholdAntipsychotic medicationSustained reductionBrain areasSchizoaffective disorderCortical activationPossible treatmentNeuropsychological impairmentNeuropsychological assessmentPatientsAdditional studiesCortexStimulationTrialsHallucinationsTreatment effects
2000
401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinations
Hoffman R, Boutros N, Berman R, Hu S, Rachid F, Schaffer N, Krystal J, Charney D. 401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinations. Biological Psychiatry 2000, 47: s122-s123. DOI: 10.1016/s0006-3223(00)00670-3.Peer-Reviewed Original ResearchTranscranial magnetic stimulation and auditory hallucinations in schizophrenia
Hoffman R, Boutros N, Hu S, Berman R, Krystal J, Charney D. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. The Lancet 2000, 355: 1073-1075. PMID: 10744097, DOI: 10.1016/s0140-6736(00)02043-2.Peer-Reviewed Original ResearchThe Emerging Neurobiology of Dissociative States
Krystal J, Bremner J, D’Souza D, Anand A, Southwick S, Charney D. The Emerging Neurobiology of Dissociative States. Springer Series On Stress And Coping 2000, 307-320. DOI: 10.1007/978-1-4615-4177-6_22.Peer-Reviewed Original ResearchPerceptual alterationsFocusing of attentionCognitive processesDistorts perceptionsPerceptual distortionReduced processingInformation processingPeripheral stimuliProlonged sensory deprivationSensory perceptionSensory deprivationPerceptionEveryday lifeDissociative statesExact transcriptionProcessingDepersonalizationMemoryIllusionNeurobiologyStimuliDerealizationHallucinationsAttentionPeople
1999
Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”
Hoffman R, Boutros N, Berman R, Roessler E, Belger A, Krystal J, Charney D. Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”. Biological Psychiatry 1999, 46: 130-132. PMID: 10394483, DOI: 10.1016/s0006-3223(98)00358-8.Peer-Reviewed Original ResearchConceptsTranscranial magnetic stimulationLow-frequency transcranial magnetic stimulationFrequency transcranial magnetic stimulationAuditory hallucinationsMagnetic stimulationTemporoparietal cortexSham stimulationPersistent auditory hallucinationsCross-over designSpeech perception areasHertz stimulationCerebral cortexSchizophrenic patientsCortical activationHallucination severityPatientsActive stimulationTotal cessationCortexStimulationHallucinationsGreater improvementActivationPrior studiesSeverity
1998
Complications of alcohol withdrawal: pathophysiological insights.
Trevisan LA, Boutros N, Petrakis IL, Krystal JH. Complications of alcohol withdrawal: pathophysiological insights. Alcohol Research 1998, 22: 61-6. PMID: 15706735, PMCID: PMC6761825.Peer-Reviewed Original ResearchConceptsAcute alcohol withdrawalAlcohol withdrawalLong-term sobrietyDelirium tremensAcute withdrawalMental confusionSignificant illnessPathophysiological insightsDisease processPsychiatric problemsCognitive impairmentComplicationsHeavy drinkingMemory disordersWithdrawalDeliriumMedicationsRelapseTremensPatientsSeizuresIllnessImpairmentSeverityHallucinations