2005
Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers
Jacobsen LK, Krystal JH, Mencl WE, Westerveld M, Frost SJ, Pugh KR. Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers. Biological Psychiatry 2005, 57: 56-66. PMID: 15607301, DOI: 10.1016/j.biopsych.2004.10.022.Peer-Reviewed Original ResearchConceptsAdolescent smokersVerbal memoryTobacco cravingAdolescent daily smokersNicotine withdrawalAdolescent tobacco smokersDaily tobacco smokersDivided attentionVerbal learningCognitive enhancementMemory performanceSustained attentionCognitive performanceGeneral intelligenceAdolescent nonsmokersPerformance decrementsParental educational attainmentFemale smokersDepressed moodMemoryAffective symptomsDaily smokersRecency of smokingTobacco smokersEarly age
2003
Preliminary evidence of hippocampal dysfunction in adolescent MDMA (“ecstasy”) users: possible relationship to neurotoxic effects
Jacobsen LK, Mencl WE, Pugh KR, Skudlarski P, Krystal JH. Preliminary evidence of hippocampal dysfunction in adolescent MDMA (“ecstasy”) users: possible relationship to neurotoxic effects. Psychopharmacology 2003, 173: 383-390. PMID: 14647960, DOI: 10.1007/s00213-003-1679-4.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMDMA usersCognitive deficitsMDMA useBrain functionDivided attentionMemory taskMemory loadResultsMDMA usersLeft hippocampusHippocampal dysfunctionSubstance useCognitive impairmentAdolescencePreliminary evidenceReaction timeDevelopmental impactPilot sampleDeficitsMDMAMagnetic resonance imagingIQAttentionMemoryHippocampus