2019
Neural computations of threat in the aftermath of combat trauma
Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.Peer-Reviewed Original ResearchConceptsPTSD symptomsPost-traumatic stress disorder symptomsHigher PTSD symptom severityThreat-predictive cuesPTSD symptom severityAssociative threatPredictive cuesNeural trackingDisorder symptomsPrediction errorCombat veteransDynamic learning rateNegative outcomesCombat traumaSmaller amygdala volumesNeural computationLatent markersSymptomatic veteransSymptom severityAmygdala volumeAssociabilityCuesLearning rateVeteransSymptoms
2017
Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD
Wrocklage KM, Averill LA, Scott J, Averill CL, Schweinsburg B, Trejo M, Roy A, Weisser V, Kelly C, Martini B, Harpaz-Rotem I, Southwick SM, Krystal JH, Abdallah CG. Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD. European Neuropsychopharmacology 2017, 27: 515-525. PMID: 28279623, PMCID: PMC5429865, DOI: 10.1016/j.euroneuro.2017.02.010.Peer-Reviewed Original ResearchConceptsClinician-Administered PTSD ScalePTSD symptom dimensionsPTSD diagnosisCombat exposureCortical thicknessSymptom dimensionsMagnetic resonance imagingPosttraumatic stress disorder (PTSD) symptomsU.S. veteransCortical thinningUnique brain regionsLeft lateral prefrontalAnxious arousalPTSD dimensionsNeural correlatesHigh-resolution magnetic resonance imagingCortical thickness reductionsLateral prefrontalPTSD symptomsDisorder symptomsCombat severityCurrent PTSDPTSD ScalePrefrontal cortexPotential confoundsCumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse
Steine IM, Winje D, Krystal JH, Bjorvatn B, Milde AM, Grønli J, Nordhus IH, Pallesen S. Cumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse. Child Abuse & Neglect 2017, 65: 99-111. PMID: 28131947, DOI: 10.1016/j.chiabu.2017.01.008.Peer-Reviewed Original ResearchConceptsCumulative childhood maltreatmentChildhood maltreatmentPosttraumatic stressSexual abuseSocial supportChildhood adversityAdult survivorsRule-governed wayHierarchical regression analysisChildhood maltreatment experiencesSelf-harm behaviorsDose-response relationCumulative childhood adversityAdult symptomatologyDisorder symptomsSelf-reported symptomsPsychological distressRelational problemsSymptom complexityMaltreatment experiencesWork functioningEmotional painRelated distressMaltreatment scoresAdversity
2014
Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study.
Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2014, 76: 546-53. PMID: 25562376, DOI: 10.4088/jcp.14m09091.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLifetime posttraumatic stress disorderHealth-related functioningMental health-related functioningDSM-5 posttraumatic stress disorderUS veteransSymptom clustersPTSD symptom clustersNational HealthVeterans StudyPTSD symptomsQuality of lifeDysphoric Arousal modelPosttraumatic stress disorder (PTSD) symptomsDSM-5 posttraumatic stress disorder symptomsDSM-5 PTSD symptom clustersHealth outcomesFemale veteransSuicidal ideationDSM-5 PTSD symptomsStress disorderSymptomsDisorder symptomsPTSD symptomatologyVeterans