2019
Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment
Abdallah CG, Averill CL, Ramage AE, Averill LA, Alkin E, Nemati S, Krystal JH, Roache JD, Resick P, Young-McCaughan S, Peterson AL, Fox P. Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment. Chronic Stress 2019, 3: 2470547019838971. PMID: 31008419, PMCID: PMC6469713, DOI: 10.1177/2470547019838971.Peer-Reviewed Original ResearchPosttraumatic stress disorderCognitive processing therapyCentral executive networkSymptom provocationPTSD treatmentSecondary analysisGroup cognitive processing therapyPTSD participantsGlobal brain connectivityEffective PTSD treatmentExecutive networkFunctional magnetic resonance imagingMagnetic resonance imagingEffect of treatmentUnknown neurobiological mechanismsUS Army soldiersTreatment periodWeek 8Higher pretreatmentMRI scansPrimary analysisResonance imagingSalience networkStress disorderBrain connectivity
2018
Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence
Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I. Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence. Chronic Stress 2018, 2: 2470547018786390. PMID: 30035247, PMCID: PMC6054445, DOI: 10.1177/2470547018786390.Peer-Reviewed Original ResearchPosttraumatic stress disorderIntrinsic connectivity distributionMedial prefrontal cortexTensor-based morphometryPTSD groupFunctional connectivityPrefrontal cortexPathophysiology of PTSDGray matter volumeWhole-brain connectivityKey brain regionsMiddle temporal gyrusDorsolateral prefrontal cortexDefault mode networkCentral executive networkFunctional connectivity analysisPFC alterationsCortical alterationsHealthy comparison participantsAltered volumeFunctional alterationsMatter volumeUnmedicated individualsCerebellar involvementBrain regions