1996
Clinical and Biochemical Effects of Catecholamine Depletion on Antidepressant-Induced Remission of Depression
Miller HL, Delgado PL, Salomon RM, Berman R, Krystal JH, Heninger GR, Charney DS. Clinical and Biochemical Effects of Catecholamine Depletion on Antidepressant-Induced Remission of Depression. JAMA Psychiatry 1996, 53: 117-128. PMID: 8629887, DOI: 10.1001/archpsyc.1996.01830020031005.Peer-Reviewed Original ResearchConceptsNorepinephrine reuptake inhibitorsReuptake inhibitorsCatecholamine depletionAlpha-methylparatyrosineTreatment groupsHamilton Depression Rating ScaleHomovanillic acid levelsSerotonin reuptake inhibitorsDepression Rating ScaleSimilar significant decreaseAntihistamine diphenhydramine hydrochlorideSeparate test sessionsFeelings of worthlessnessConsiderable sedationLoss of interestDepressed patientsDepressive relapseAntidepressant drugsInactive placeboTherapeutic effectTherapeutic mechanismDepressive symptomsCatecholamine metabolitesPlasma 3Remission
1985
Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stress
van der Kolk B, Greenberg M, Boyd H, Krystal J. Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stress. Biological Psychiatry 1985, 20: 314-325. PMID: 2858226, DOI: 10.1016/0006-3223(85)90061-7.Peer-Reviewed Original ResearchConceptsPost-traumatic stressStress-induced analgesiaTraumatic stressInescapable shockChronic post-traumatic stressCatecholamine depletionMassive psychic traumaEndogenous opioid releasePhysiological hyperreactivityTraumatized individualsPsychic traumaBehavioral sequelaeOpioid withdrawalPsychodynamic conceptsEndogenous opioidsPsychosocial meaningOpioid releaseMental disordersTraumaPhysiological componentsReexposureHuman equivalentAnalgesiaHyperreactivityAnimals