2005
Abnormal hemodynamics in schizophrenia during an auditory oddball task
Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry 2005, 57: 1029-1040. PMID: 15860344, PMCID: PMC2771438, DOI: 10.1016/j.biopsych.2005.01.035.Peer-Reviewed Original ResearchConceptsAuditory oddball taskHealthy participantsOddball taskThree-stimulus auditory oddball taskDiffuse brain abnormalitiesHealthy control subjectsNovelty processingWidespread pathologic processCerebral areasControl subjectsBrain abnormalitiesMagnetic resonance imaging dataAbnormal hemodynamicsPathologic processesSchizophrenia patientsParietal cortexCognitive functionHeterogeneous disorderCerebellar circuitsSchizophreniaAbnormalitiesSignificant activationSubcortical systemsFunctional magnetic resonance imaging (fMRI) dataPatientsApplications of Morphometric and Diffusion Tensor Magnetic Resonance Imaging to the Study of Brain Abnormalities in the Alcoholism Spectrum
Daurignac E, Toga A, Jones D, Aronen H, Hommer D, Jernigan T, Krystal J, Mathalon D. Applications of Morphometric and Diffusion Tensor Magnetic Resonance Imaging to the Study of Brain Abnormalities in the Alcoholism Spectrum. Alcohol Clinical And Experimental Research 2005, 29: 159-166. PMID: 15895490, DOI: 10.1097/01.alc.0000150891.72900.62.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingBrain abnormalitiesAlcohol exposureMicrostructural brain abnormalitiesMicrostructural brain alterationsBrain volume deficitsRecent magnetic resonance imagingPrenatal alcohol exposureWhite matter tract integrityWhite matter tractsStructural MRI methodsDiffusion tensor magnetic resonanceChronic alcoholicsBrain alterationsClinical subtypesMorphometric abnormalitiesAlcoholic drinkingVolume deficitsClinical subpopulationsResonance imagingTract integrityNeuropsychiatric diseasesUnique anatomyMicrostructural disruptionStudy of alcoholism
2002
Frontotemporal neural systems in bipolar disorder.
Blumberg HP, Charney DS, Krystal JH. Frontotemporal neural systems in bipolar disorder. Seminars In Clinical Neuropsychiatry 2002, 7: 243-54. PMID: 12382207, DOI: 10.1053/scnp.2002.35220.Peer-Reviewed Original ResearchConceptsBipolar disorderBD symptomsNeural system abnormalitiesRegional brain abnormalitiesLocalization of lesionsAmygdalar abnormalitiesNeural systemsFrontotemporal neural systemBrain abnormalitiesBrain lesionsSystem abnormalitiesManic stateMood symptomsTrait abnormalityUnipolar depressionAbnormalitiesMood changesVivo evidenceSymptomsPotential targetNeuroanatomic modelLesionsDisordersDepressionInvolvement