2005
Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder
Blumberg HP, Donegan NH, Sanislow CA, Collins S, Lacadie C, Skudlarski P, Gueorguieva R, Fulbright RK, McGlashan TH, Gore JC, Krystal JH. Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology 2005, 183: 308-313. PMID: 16249909, DOI: 10.1007/s00213-005-0156-7.Peer-Reviewed Original ResearchConceptsUnmedicated bipolar disorderMood-stabilizing medicationsBipolar disorderBD participantsPotential treatment targetMagnetic resonance imagingPreliminary evidenceMethodsFunctional magnetic resonance imagingAnterior cingulate activationResultsThe groupMedication effectsFunctional abnormalitiesHealthy comparison participantsObjectivesThe aimAnterior cingulateTreatment targetsResonance imagingMedicationsHC participantsAmygdala activationCingulate activationAmygdala increasesComparison participantsEmotional stimuliAbnormalities
1998
Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil
Abi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil. American Journal Of Psychiatry 1998, 155: 1550-1555. PMID: 9812116, DOI: 10.1176/ajp.155.11.1550.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsBenzodiazepine receptorsComparison subjectsAlcoholic subjectsDistribution volumeAlcoholic patientsAnterior cingulateBenzodiazepine receptor densityRight middle frontal gyrusLeft occipital cortexType II alcoholismSingle photon emissionMiddle frontal gyrusStatistical parametric mappingContinuous infusionReceptor radiotracerReceptor densityOccipital cortexCerebellar cortexCortical regionsPatientsFrontal gyrusInterest analysisVivo studiesParametric mapping