2010
Sex Differences in Striatal Dopamine Release in Young Adults After Oral Alcohol Challenge: A Positron Emission Tomography Imaging Study With [11C]Raclopride
Urban NB, Kegeles LS, Slifstein M, Xu X, Martinez D, Sakr E, Castillo F, Moadel T, O'Malley SS, Krystal JH, Abi-Dargham A. Sex Differences in Striatal Dopamine Release in Young Adults After Oral Alcohol Challenge: A Positron Emission Tomography Imaging Study With [11C]Raclopride. Biological Psychiatry 2010, 68: 689-696. PMID: 20678752, PMCID: PMC2949533, DOI: 10.1016/j.biopsych.2010.06.005.Peer-Reviewed Original ResearchConceptsDopamine releaseStriatal subregionsAlcohol-induced dopamine releasePositron emission tomography scanAlcohol challengeStriatal dopamine releaseEmission tomography scanMaximum alcohol consumptionOral alcohol challengePositron emission tomographySex differencesAlcohol administrationYoung social drinkersTomography scanAbility of alcoholOral alcoholRewarding effectsMixed model analysisAlcohol consumptionAbuse liabilitySeparate daysSignificant negative correlationEmission tomographyVentral striatumSignificant positive correlation
2006
Enhanced Sensitivity to the Euphoric Effects of Alcohol in Schizophrenia
D'Souza DC, Gil RB, Madonick S, Perry EB, Forselius-Bielen K, Braley G, Donahue L, Tellioglu T, Zimolo Z, Gueorguieva R, Krystal JH. Enhanced Sensitivity to the Euphoric Effects of Alcohol in Schizophrenia. Neuropsychopharmacology 2006, 31: 2767-2775. PMID: 16985503, DOI: 10.1038/sj.npp.1301207.Peer-Reviewed Original ResearchConceptsEffects of alcoholHealthy subjectsBlood alcohol levelsPositive psychotic symptomsSmall transient increaseSelf-medication hypothesisPerceptual alterationsAlcohol administrationMotor functionAlcohol dosesElevated riskPsychotic symptomsLifetime exposureSchizophrenia patientsSchizophrenia symptomsEuphoric effectsNegative symptomsAlcohol levelsAlcohol useStimulatory effectSubjective effectsTransient increaseSchizophreniaStimulatory responseAlcohol responses