2017
Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study
Steine IM, Winje D, Skogen JC, Krystal JH, Milde AM, Bjorvatn B, Nordhus IH, Grønli J, Pallesen S. Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study. Child Abuse & Neglect 2017, 67: 280-293. PMID: 28327414, DOI: 10.1016/j.chiabu.2017.03.002.Peer-Reviewed Original ResearchConceptsChildhood sexual abuseSexual abuseAdult survivorsPosttraumatic Stress Symptom TrajectoriesSexual abuse survivorsClinical-level symptomsLatent profile analysisAbuse survivorsRelational difficultiesAbusive experiencesPTSS trajectoriesPenetrative abusePTSSChildhood maltreatmentBest overall fitSocial supportIntense anxietyNorwegian sampleBiological parentsLongitudinal studySymptom trajectoriesClinical interventionsSymptom profilesAbuseOverall fit
2011
Insomnia, Nightmare Frequency, and Nightmare Distress in Victims of Sexual Abuse
Steine IM, Krystal JH, Nordhus IH, Bjorvatn B, Harvey AG, Eid J, Grønli J, Milde AM, Pallesen S. Insomnia, Nightmare Frequency, and Nightmare Distress in Victims of Sexual Abuse. Journal Of Interpersonal Violence 2011, 27: 1827-1843. PMID: 22204947, DOI: 10.1177/0886260511430385.Peer-Reviewed Original Research
2007
Imaging the Neurochemistry of Alcohol and Substance Abuse
Martinez D, Kim JH, Krystal J, Abi-Dargham A. Imaging the Neurochemistry of Alcohol and Substance Abuse. Neuroimaging Clinics Of North America 2007, 17: 539-555. PMID: 17983969, DOI: 10.1016/j.nic.2007.07.004.Peer-Reviewed Original Research
2003
N-methyl-d-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability
Krystal JH, Petrakis IL, Mason G, Trevisan L, D'Souza DC. N-methyl-d-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacology & Therapeutics 2003, 99: 79-94. PMID: 12804700, DOI: 10.1016/s0163-7258(03)00054-8.Peer-Reviewed Original ResearchConceptsGlutamatergic systemEthanol abuseGlutamate receptorsN-methyl-D-aspartate (NMDA) subtypePrimary excitatory neurotransmitterAspartate glutamate receptorsAction of ethanolEthanol withdrawalGlutamatergic agentsGlutamatergic functionExcitatory neurotransmitterTranslational neuroscience perspectiveGlutamate systemEthanol intoxicationBehavioral effectsEthanol contributeAlcoholismBrainReceptorsTreatmentAbuseN-methylSubtypesNeurotransmittersIntoxication
2000
Comorbidity of psychiatric and substance abuse disorders
George T, Krystal J. Comorbidity of psychiatric and substance abuse disorders. Current Opinion In Psychiatry 2000, 13: 327-331. DOI: 10.1097/00001504-200005000-00015.Peer-Reviewed Original Research
1999
Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients
Krystal J, D'Souza D, Madonick S, Petrakis I. Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients. Schizophrenia Research 1999, 35: s35-s49. PMID: 10190224, DOI: 10.1016/s0920-9964(98)00162-5.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsSubstance abuseTerms of rehospitalizationComorbid substance abuseExacerbation of symptomsHealth care expensesSelf-medication hypothesisBetter prognosisMedical illnessPharmacotherapeutic approachesRational pharmacotherapyNonschizophrenic populationsPatientsVocational functionIllicit substancesCare expensesAbuseVulnerability hypothesisRehospitalizationExacerbationMedicationsPharmacotherapyPrognosisPsychostimulantsIllness
1996
Neural Mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the "false memory syndrome"
Bremner JD, Krystal JH, Charney DS, Southwick SM. Neural Mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the "false memory syndrome". American Journal Of Psychiatry 1996, 153: 71-82. PMID: 8659644, DOI: 10.1176/ajp.153.7.71.Peer-Reviewed Original ResearchConceptsFalse memory syndromeMemory tracesChildhood abuseDissociative amnesiaEffects of stressMemory functionMemory syndromeNeurobiology of memoryBrain regionsNormal memory functionChildren's memoryTraumatic stressorsSpecific brain regionsNeural mechanismsStressful eventsMemoryAmnesiaExtreme stressBrain chemistryAbuseRecallPsychiatric disordersLong-term alterationsLong-term effectsNormal persons
1988
Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance Abuse
Kosten T, Krystal J. Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance Abuse. Recent Developments In Alcoholism 1988, 6: 49-68. PMID: 3283864, DOI: 10.1007/978-1-4615-7718-8_3.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderSubstance abuseHuman studiesEndogenous opioid systemCentral catecholaminesOpioid systemBrain catecholaminesEmotional response modelsTherapeutic approachesAnimal studiesSignificant biological contributionStress disorderNonhuman primatesBehavioral correlatesCatecholaminesRelevant animalBiological mechanismsRecent studiesAbuseIndirect measureSyndromeIncidenceStudy