2024
The role of anatomic shape features in the prognosis of uncomplicated type B aortic dissection initially treated with optimal medical therapy
Liu M, Dong H, Mazlout A, Wu Y, Kalyanasundaram A, Oshinski J, Sun W, Elefteriades J, Leshnower B, Gleason R. The role of anatomic shape features in the prognosis of uncomplicated type B aortic dissection initially treated with optimal medical therapy. Computers In Biology And Medicine 2024, 170: 108041. PMID: 38330820, PMCID: PMC10932856, DOI: 10.1016/j.compbiomed.2024.108041.Peer-Reviewed Original ResearchConceptsType B aortic dissectionTreated with optimal medical therapyAortic growth rateOptimal medical therapyUncomplicated type B aortic dissectionB aortic dissectionMedical therapyCT scanPatients' long-term survivalType B aortic dissection patientsLong-term outcomesLong-term survivalFailure groupAortic expansionChronic phaseFailure patientsPatientsCT imagesTherapyDissectionStatistical shape modelFailurePrognosisScanningRegression
2023
“Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute
Zafar M, Ziganshin B, Li Y, Ostberg N, Rizzo J, Tranquilli M, Mukherjee S, Elefteriades J. “Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute. The Yale Journal Of Biology And Medicine 2023, 96: 427-440. PMID: 37780996, PMCID: PMC10524815, DOI: 10.59249/lndz2964.Peer-Reviewed Original ResearchConceptsBig dataArtificial intelligenceThoracic aortic aneurysmArtificial intelligence techniquesData setsAortic aneurysmLarge clinical data setsIntelligence techniquesAdvanced machineYale-New Haven HospitalClinical data setsAortic aneurysm patientsAortic root dilatationBicuspid aortic valveProspective clinical databaseNew Haven HospitalLarge genetic data setsIntelligenceSequencing filesThoracoabdominal aortaAortic dilatationMale patientsRisk prognosticationRoot dilatationSurgical treatmentPyTorch-FEA: Autograd-enabled finite element analysis methods with applications for biomechanical analysis of human aorta
Liang L, Liu M, Elefteriades J, Sun W. PyTorch-FEA: Autograd-enabled finite element analysis methods with applications for biomechanical analysis of human aorta. Computer Methods And Programs In Biomedicine 2023, 238: 107616. PMID: 37230048, PMCID: PMC10330852, DOI: 10.1016/j.cmpb.2023.107616.Peer-Reviewed Original ResearchConceptsDeep neural networksFinite element analysisFEA codeImproved loss functionInverse methodFinite element analysis methodInverse problemCommercial FEA software packageElement analysis methodFEA software packageCommercial FEA packageNew libraryNeural networkPerformance issuesFEA packageNew inverse methodBiomechanical analysisComputational timeFEA methodLoss functionSolid mechanicsDeformation analysisSoftware packageInverse analysisSeries of applicationsNatural History and Intervention Thresholds for Ascending Thoracic Aortic Aneurysm—Not an Easy Nut to Crack
Zafar M, Elefteriades J. Natural History and Intervention Thresholds for Ascending Thoracic Aortic Aneurysm—Not an Easy Nut to Crack. JAMA Cardiology 2023, 8: 512-512. PMID: 36920367, DOI: 10.1001/jamacardio.2023.0153.Peer-Reviewed Original ResearchAortic Size at the Time of Type A and Type B Dissections
Perez Z, Zafar M, Velasco J, Sonsino A, Ellauzi H, John C, Kalyanasundaram A, Ziganshin B, Elefteriades J. Aortic Size at the Time of Type A and Type B Dissections. The Annals Of Thoracic Surgery 2023, 116: 262-268. PMID: 37062339, DOI: 10.1016/j.athoracsur.2023.03.037.Peer-Reviewed Original ResearchConceptsType B dissectionTime of dissectionB dissectionAortic sizeAortic diameterBicuspid aortic valveThoracic aortic aneurysmAortic interventionAortic dissectionSurgical interventionAortic aneurysmFemale sexAortic valveThoracic aortaProphylactic repairUnadjusted regressionLeft shiftLogistic regressionDissectionNew guidelinesType ASize criteriaOddsInterventionTime of typesExtended law of laplace for measurement of the cloverleaf anatomy of the aortic root
Ban E, Kalogerakos P, Khosravi R, Ziganshin B, Ellauzi H, Ramachandra A, Zafar M, Humphrey J, Elefteriades J. Extended law of laplace for measurement of the cloverleaf anatomy of the aortic root. The International Journal Of Cardiovascular Imaging 2023, 39: 1345-1356. PMID: 37046157, PMCID: PMC10250276, DOI: 10.1007/s10554-023-02847-5.Peer-Reviewed Original ResearchFate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Wu J, Zafar M, Liu Y, Chen J, Li Y, Ziganshin B, Ellauzi H, Mukherjee S, Rizzo J, Elefteriades J. Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University. European Heart Journal 2023, 44: 4579-4588. PMID: 36994934, DOI: 10.1093/eurheartj/ehad148.Peer-Reviewed Original ResearchConceptsAdverse aortic eventsThoracic aortic aneurysmAortic sizeAortic aneurysmCox regressionAortic growthRisk factorsSignificant independent risk factorsMultivariable Cox regressionIndependent risk factorCohort of patientsUnivariable Cox regressionSignificant protective factorAortic deathATAA patientsAortic eventsPrimary endpointSurgical interventionThree-decade experienceNatural historyYearly riskProtective factorsAneurysmsPatientsIntervention criteriaAortic Root Diameter in Elite Athletes
Elefteriades J. Aortic Root Diameter in Elite Athletes. Canadian Journal Of Cardiology 2023, 39: 898-900. PMID: 36963721, DOI: 10.1016/j.cjca.2023.03.015.Peer-Reviewed Original ResearchKIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection
Velasco J, Li Y, Ziganshin B, Zafar M, Rizzo J, Ma D, Zang H, Kalyanasundaram A, Elefteriades J. KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection. Genes 2023, 14: 252. PMID: 36833179, PMCID: PMC9956195, DOI: 10.3390/genes14020252.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic dissectionOdds ratioVariant statusArg allele carriersThoracic aortic dissectionOccurrence of ADAortic sizeArg alleleMarked adverse impactTAA patientsAortic aneurysmClinical assessmentSurgical decisionAllele carriersIncrease riskVariant patientsArg carriersPilot studyDissectionImportant intracellular functionsConfirmatory findingsPatientsAneurysmsPresent study
2022
No Shame in Sole Ascending Aortic Replacement for Acute Type A Aortic Dissection
Elefteriades J. No Shame in Sole Ascending Aortic Replacement for Acute Type A Aortic Dissection. The Annals Of Thoracic Surgery 2022, 115: 895. PMID: 36460063, DOI: 10.1016/j.athoracsur.2022.11.014.Peer-Reviewed Original ResearchAscending aneurysmectomy: Should we shift to the left? ∗
Elefteriades J, Rizzo J, Zafar M, Ziganshin B. Ascending aneurysmectomy: Should we shift to the left? ∗. Journal Of Thoracic And Cardiovascular Surgery 2022, 166: 435-441. PMID: 36109210, DOI: 10.1016/j.jtcvs.2022.07.033.Peer-Reviewed Original Research
2020
Essential information on surgical heart valve characteristics for optimal valve prosthesis selection: Expert consensus document from the European Association for Cardio-Thoracic Surgery (EACTS)–The Society of Thoracic Surgeons (STS)–American Association for Thoracic Surgery (AATS) Valve Labelling Task Force
Durko AP, Pibarot P, Atluri P, Bapat V, Cameron D, Casselman FPA, Chen EP, Dahle G, Elefteriades JA, Lancellotti P, Prager RL, Rosenhek R, Speir A, Stijnen M, Tasca G, Yoganathan A, Walther T, De Paulis R, Force E, De Paulis R, Atluri P, Bapat V, Cameron D, Casselman F, Chen E, Dahle G, Durko A, Elefteriades J, Prager R, Speir A, Tasca G, Lancellotti P, Pibarot P, Rosenhek R, de Hart J, Stijnen M, Yoganathan A, Ibrahim N, Laschinger J, Wu C, Di Rienzo G, McLaren A, Randall H, Becker L, Capps S, Duncan B, Green C, Hay J, Head S, Ieropoli O, Jacob A, Kappetein A, Manasse E, Marquez S, Northrup W, Ryan T, Smith W. Essential information on surgical heart valve characteristics for optimal valve prosthesis selection: Expert consensus document from the European Association for Cardio-Thoracic Surgery (EACTS)–The Society of Thoracic Surgeons (STS)–American Association for Thoracic Surgery (AATS) Valve Labelling Task Force. Journal Of Thoracic And Cardiovascular Surgery 2020, 161: 545-558. PMID: 33070936, DOI: 10.1016/j.jtcvs.2020.10.001.Peer-Reviewed Original ResearchEssential Information on Surgical Heart Valve Characteristics for Optimal Valve Prosthesis Selection: Expert Consensus Document From the European Association for Cardio-Thoracic Surgery (EACTS)–The Society of Thoracic Surgeons (STS)–American Association for Thoracic Surgery (AATS) Valve Labelling Task Force
Durko AP, Pibarot P, Atluri P, Bapat V, Cameron D, Casselman FPA, Chen EP, Dahle G, Elefteriades JA, Lancellotti P, Prager RL, Rosenhek R, Speir A, Stijnen M, Tasca G, Yoganathan A, Walther T, De Paulis R, Force ;, De Paulis R, Atluri P, Bapat V, Cameron D, Casselman F, Chen E, Dahle G, Durko A, Elefteriades J, Prager R, Speir A, Tasca G, Walther T, Lancellotti P, Pibarot P, Rosenhek R, de Hart J, Stijnen M, Yoganathan A, Ibrahim N, Laschinger J, Wu C, Di Rienzo G, McLaren A, Randall H, Becker L, Capps S, Duncan B, Green C, Hay J, Head S, Ieropoli O, Jacob A, Kappetein A, Manasse E, Marquez S, Northrup W, Ryan T, Smith W. Essential Information on Surgical Heart Valve Characteristics for Optimal Valve Prosthesis Selection: Expert Consensus Document From the European Association for Cardio-Thoracic Surgery (EACTS)–The Society of Thoracic Surgeons (STS)–American Association for Thoracic Surgery (AATS) Valve Labelling Task Force. The Annals Of Thoracic Surgery 2020, 111: 314-326. PMID: 33036738, DOI: 10.1016/j.athoracsur.2020.05.060.Peer-Reviewed Original Research
2016
Neurological Events Following Transcatheter Aortic Valve Replacement and Their Predictors
Kleiman N, Maini B, Reardon M, Conte J, Katz S, Rajagopal V, Kauten J, Hartman A, McKay R, Hagberg R, Huang J, Popma J, Adams D, Ad N, Aharonian V, Anderson W, Applegate R, Bafi A, Bajwa T, Bakhos M, Ball S, Batra S, Beohar N, Brachinsky W, Brinster D, Brown J, Byrne J, Byrne T, Casale A, Caskey M, Chawla A, Cohen H, Coselli J, Costa M, Cheatham J, Chetcuti S, Crestanello J, Davis T, Michael Deeb G, Diez J, Dauerman H, Elefteriades J, Fail P, Feinberg E, Fontana G, Forrest J, Galloway A, Giacomini J, Gleason T, Guadiani V, Harrison J, Hebeler R, Heimansohn D, Heiser J, Heller L, Henry S, Hermiller J, Hockmuth D, Hughes G, Joye J, Kafi A, Kar B, Khabbaz K, Kipperman R, Kliger C, Kon N, Lamelas J, Lee J, Leya F, Londono J, Macheers S, Mangi A, de Marchena E, Markowitz A, Matthews R, Merhi W, Mumtaz M, O’Hair D, Petrossian G, Pfeffer T, Raybuck B, Resar J, Robbins M, Robbins R, Robinson N, Ring M, Salerno T, Schreiber T, Schmoker J, Sharma S, Siwek L, Skelding K, Slater J, Starnes V, Stoler R, Subramanian V, Tadros P, Thompson C, Waksman R, Watson D, Yakubov S, Zhao D, Zorn G. Neurological Events Following Transcatheter Aortic Valve Replacement and Their Predictors. Circulation Cardiovascular Interventions 2016, 9: e003551. PMID: 27601429, DOI: 10.1161/circinterventions.115.003551.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBalloon ValvuloplastyBioprosthesisCalcinosisCardiac Pacing, ArtificialClinical Trials as TopicFemaleHeart Valve ProsthesisHumansIncidenceIntracranial EmbolismKaplan-Meier EstimateMaleProportional Hazards ModelsRisk AssessmentRisk FactorsSeverity of Illness IndexStrokeTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementEarly strokePrior coronary artery bypass surgeryHealth Stroke Scale scoreSelf-expanding CoreValve bioprosthesisCoronary artery bypass surgerySmaller body surface areaLower body mass indexContinued Access StudySevere aortic calcificationStroke Scale scoreTransient ischemic attackArtery bypass surgeryPeripheral vascular diseasePredictors of strokeBody mass indexBody surface areaIdentification of predictorsCoreValve bioprosthesisIschemic attackPrior strokeBypass surgeryAortic calcification
2015
Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR
Koyner JL, Coca SG, Thiessen-Philbrook H, Patel UD, Shlipak MG, Garg AX, Parikh CR, Consortium T, Raman J, Jeevanandam V, Akhter S, Devarajan P, Bennett M, Ma Q, Griffiths R, Edelstein C, Passik C, Nagy J, Swaminathan M, Chu M, Goldbach M, Guo L, McKenzie N, Myers M, Novick R, Quantz M, Schumann V, Webster L, Zappitelli M, Palijan A, Dewar M, Darr U, Hashim S, Elefteriades J, Geirsson A, Garwood S, Kemp R, Butrymowicz I. Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR. American Journal Of Kidney Diseases 2015, 66: 1006-1014. PMID: 26386737, PMCID: PMC4658239, DOI: 10.1053/j.ajkd.2015.07.027.Peer-Reviewed Original ResearchConceptsAcute kidney injurySevere acute kidney injuryPost-operative dialysisBaseline eGFRKidney injuryInterleukin-18Urinary biomarkersDevelopment of AKIAKI Network stage 1Clinical acute kidney injuryPerioperative acute kidney injuryKidney injury molecule-1Liver-type fatty acid binding proteinBaseline kidney functionImpact of PreoperativeSerum creatinine levelsHours of surgeryInjury molecule-1Prospective cohort studyGlomerular filtration rateNumber of patientsPerformance of biomarkersFatty acid binding proteinAdjusted RRsPreoperative eGFRMultimodality Imaging of Diseases of the Thoracic Aorta in Adults: From the American Society of Echocardiography and the European Association of Cardiovascular Imaging Endorsed by the Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance
Goldstein SA, Evangelista A, Abbara S, Arai A, Asch FM, Badano LP, Bolen MA, Connolly HM, Cuéllar-Calàbria H, Czerny M, Devereux RB, Erbel RA, Fattori R, Isselbacher EM, Lindsay JM, McCulloch M, Michelena HI, Nienaber CA, Oh JK, Pepi M, Taylor AJ, Weinsaft JW, Zamorano JL, Editors C, Dietz H, Eagle K, Elefteriades J, Jondeau G, Rousseau H, Schepens M. Multimodality Imaging of Diseases of the Thoracic Aorta in Adults: From the American Society of Echocardiography and the European Association of Cardiovascular Imaging Endorsed by the Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance. Journal Of The American Society Of Echocardiography 2015, 28: 119-182. PMID: 25623219, DOI: 10.1016/j.echo.2014.11.015.Peer-Reviewed Original Research
2013
Preoperative angiotensin-converting enzyme inhibitors and angiotensin receptor blocker use and acute kidney injury in patients undergoing cardiac surgery
Coca SG, Garg AX, Swaminathan M, Garwood S, Hong K, Thiessen-Philbrook H, Passik C, Koyner JL, Parikh CR, Consortium O, Jai R, Jeevanandam V, Akhter S, Devarajan P, Bennett M, Edelsteinm C, Patel U, Chu M, Goldbach M, Guo L, McKenzie N, Myers M, Novick R, Quantz M, Zappitelli M, Dewar M, Darr U, Hashim S, Elefteriades J, Geirsson A. Preoperative angiotensin-converting enzyme inhibitors and angiotensin receptor blocker use and acute kidney injury in patients undergoing cardiac surgery. Nephrology Dialysis Transplantation 2013, 28: 2787-2799. PMID: 24081864, PMCID: PMC3811062, DOI: 10.1093/ndt/gft405.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsBiomarkersCardiac Surgical ProceduresCoronary Artery DiseaseFemaleHumansIncidenceKidney Function TestsMaleMiddle AgedPreoperative CarePrognosisProspective StudiesReceptors, AngiotensinUnited StatesConceptsStructural acute kidney injuryAcute kidney injuryAngiotensin-converting enzyme inhibitorAngiotensin receptor blockersACEI/angiotensin receptor blockerACEI/ARB exposureKidney injurySerum creatinineARB exposureCardiac surgeryUrinary biomarkersEnzyme inhibitorsPreoperative angiotensin-converting enzyme inhibitorACEI/ARB usageAngiotensin receptor blocker useFunctional acute kidney injuryPostoperative acute kidney injuryACEI/ARB useAKI stage 1New urinary biomarkersMorning of surgeryReceptor blocker useCo-primary outcomesProspective cohort studyARB usage
2009
Deep Hypothermic Circulatory Arrest in Patients With High Cognitive Needs: Full Preservation of Cognitive Abilities
Percy A, Widman S, Rizzo JA, Tranquilli M, Elefteriades JA. Deep Hypothermic Circulatory Arrest in Patients With High Cognitive Needs: Full Preservation of Cognitive Abilities. The Annals Of Thoracic Surgery 2009, 87: 117-123. PMID: 19101283, DOI: 10.1016/j.athoracsur.2008.10.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAorta, ThoracicAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationCase-Control StudiesCirculatory Arrest, Deep Hypothermia InducedCognitionCognition DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedPatient SatisfactionPostoperative CarePreoperative CareProbabilityPsychometricsRadiographyReference ValuesRetrospective StudiesRisk AssessmentSurveys and QuestionnairesTreatment OutcomeVascular Surgical ProceduresConceptsDeep hypothermic circulatory arrestHypothermic circulatory arrestAortic surgeryCirculatory arrestStudy groupStraight deep hypothermic circulatory arrestYale-New Haven HospitalOpen distal anastomosisThoracic aortic surgeryTotal arch replacementArch replacementCerebral protectionPreoperative statusDistal anastomosisSuch patientsFunctional outcomeControl subjectsPatientsSurgeryControl groupAdverse effectsSignificant differencesCognitive changesDaily activitiesOverall score
2008
Unilateral diaphragm paralysis: etiology, impact, and natural history.
Elefteriades J, Singh M, Tang P, Siegel MD, Kenney B, Pandey A, Kopf GS. Unilateral diaphragm paralysis: etiology, impact, and natural history. The Journal Of Cardiovascular Surgery 2008, 49: 289-95. PMID: 18431352.Peer-Reviewed Original ResearchConceptsUnilateral diaphragm paralysisDiaphragm paralysisChronic obstructive pulmonary diseaseNatural historyBilateral diaphragm paralysisIntact phrenic nerveObstructive pulmonary diseaseSpirometric improvementClinical improvementExpiratory volumePulmonary infectionDiaphragm resectionLeft diaphragmOccasional patientPhrenic nervePulmonary diseaseSurgical explorationDiaphragm functionLower lobeVital capacityClinical recordsClinical spectrumMean durationNeurogenic atrophyBest therapy
2007
Gene Expression Signature in Peripheral Blood Detects Thoracic Aortic Aneurysm
Wang Y, Barbacioru CC, Shiffman D, Balasubramanian S, Iakoubova O, Tranquilli M, Albornoz G, Blake J, Mehmet NN, Ngadimo D, Poulter K, Chan F, Samaha RR, Elefteriades JA. Gene Expression Signature in Peripheral Blood Detects Thoracic Aortic Aneurysm. PLOS ONE 2007, 2: e1050. PMID: 17940614, PMCID: PMC2002514, DOI: 10.1371/journal.pone.0001050.Peer-Reviewed Original ResearchMeSH KeywordsAortic Aneurysm, ThoracicCase-Control StudiesCluster AnalysisFalse Positive ReactionsGene ExpressionGene Expression ProfilingGene Expression RegulationGenome, HumanHumansOligonucleotide Array Sequence AnalysisReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityTranscription, GeneticConceptsPeripheral blood cellsGene expression signaturesAortic aneurysmPeripheral bloodTAA patientsExpression signaturesBlood cellsBlood-based gene expression testAdverse clinical outcomesElective surgical repairThoracic aortic aneurysmPeripheral blood samplesPotential diagnostic markerPotential signature genesClassifier genesGene expression testDistinct gene expression signaturesSurgical repairClinical outcomesReal-time PCRBlood samplesRisk individualsTherapeutic interventionsDisease statusHigh mortality