2023
“Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute
Zafar M, Ziganshin B, Li Y, Ostberg N, Rizzo J, Tranquilli M, Mukherjee S, Elefteriades J. “Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute. The Yale Journal Of Biology And Medicine 2023, 96: 427-440. PMID: 37780996, PMCID: PMC10524815, DOI: 10.59249/lndz2964.Peer-Reviewed Original ResearchConceptsBig dataArtificial intelligenceThoracic aortic aneurysmArtificial intelligence techniquesData setsAortic aneurysmLarge clinical data setsIntelligence techniquesAdvanced machineYale-New Haven HospitalClinical data setsAortic aneurysm patientsAortic root dilatationBicuspid aortic valveProspective clinical databaseNew Haven HospitalLarge genetic data setsIntelligenceSequencing filesThoracoabdominal aortaAortic dilatationMale patientsRisk prognosticationRoot dilatationSurgical treatmentSafety of cerebrospinal fluid drainage in descending and thoracoabdominal aortic replacement surgery
Nasir A, Zafar M, Abdelbaky M, Papanikolaou D, Ellauzi H, Shaikh M, Ziganshin B, Elefteriades J. Safety of cerebrospinal fluid drainage in descending and thoracoabdominal aortic replacement surgery. Annals Of Cardiothoracic Surgery 2023, 12: 47683-47483. PMID: 37817851, PMCID: PMC10561341, DOI: 10.21037/acs-2023-scp-0121.Peer-Reviewed Original ResearchCerebrospinal fluid drainageThoracoabdominal aortic aneurysmsSpinal cord injuryOpen surgical repairSurgical repairElectronic health recordsAortic aneurysmFluid drainagePersistent cerebrospinal fluid leakageAortic replacement surgeryMean hospital lengthSpinal cord protectionRetrospective chart reviewThoracic aortic aneurysmThoracoabdominal aortic diseaseCerebrospinal fluid leakageLong-term survivalHospital mortalityHospital lengthPermanent paraplegiaChart reviewMinor complicationsPatient agePostoperative courseCutaneous fistulaNatural History and Intervention Thresholds for Ascending Thoracic Aortic Aneurysm—Not an Easy Nut to Crack
Zafar M, Elefteriades J. Natural History and Intervention Thresholds for Ascending Thoracic Aortic Aneurysm—Not an Easy Nut to Crack. JAMA Cardiology 2023, 8: 512-512. PMID: 36920367, DOI: 10.1001/jamacardio.2023.0153.Peer-Reviewed Original ResearchThe natural history of aortic root aneurysms
Ziganshin B, Kargin N, Zafar M, Elefteriades J. The natural history of aortic root aneurysms. Annals Of Cardiothoracic Surgery 2023, 12: 21324-21224. PMID: 37304695, PMCID: PMC10248916, DOI: 10.21037/acs-2023-avs1-20.Peer-Reviewed Original ResearchBicuspid aortopathy does not require earlier surgical intervention
Zafar M, Wu J, Vinholo T, Li Y, Papanikolaou D, Ellauzi H, Ostberg N, Kalyanasundaram A, Kalogerakos P, Mukherjee S, Ziganshin B, Rizzo J, Elefteriades J. Bicuspid aortopathy does not require earlier surgical intervention. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 760-769.e4. PMID: 37088130, DOI: 10.1016/j.jtcvs.2023.04.017.Peer-Reviewed Original ResearchBicuspid aortic valveAdverse aortic eventsEvent-free survivalAortic eventsAortic sizeAortic diameterAortic growth rateEarly surgical interventionLong-term complicationsRisk of complicationsThoracic aortic aneurysmAortic deathComplication rateSurgical repairOperative repairProphylactic surgerySurgical interventionAortic aneurysmAortic valveSurgical correctionBicuspid aortopathyRelative riskExpert centersTAV-ATAAPatientsAortic Size at the Time of Type A and Type B Dissections
Perez Z, Zafar M, Velasco J, Sonsino A, Ellauzi H, John C, Kalyanasundaram A, Ziganshin B, Elefteriades J. Aortic Size at the Time of Type A and Type B Dissections. The Annals Of Thoracic Surgery 2023, 116: 262-268. PMID: 37062339, DOI: 10.1016/j.athoracsur.2023.03.037.Peer-Reviewed Original ResearchConceptsType B dissectionTime of dissectionB dissectionAortic sizeAortic diameterBicuspid aortic valveThoracic aortic aneurysmAortic interventionAortic dissectionSurgical interventionAortic aneurysmFemale sexAortic valveThoracic aortaProphylactic repairUnadjusted regressionLeft shiftLogistic regressionDissectionNew guidelinesType ASize criteriaOddsInterventionTime of typesNonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta
Elefteriades J, Ziganshin B, Zafar M. Nonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta. Aorta 2023, 11: 071-086. PMID: 37172942, PMCID: PMC10232037, DOI: 10.1055/s-0043-1766114.Peer-Reviewed Original ResearchThoracic aortic aneurysmSurgical interventionAortic eventsAortic dissectionSubsternal chest painBlood pressure elevationBicuspid aortic valveAfferent neural pathwaysAscending thoracic aortaEmission Tomography ImagingPositron emission tomography (PET) imagingAortic stressAscending aneurysmAortic surgeryChest painEarly surgerySpecific genetic aberrationsHigh rupture riskMural thickeningRoot dilatationBicuspid valvePressure elevationAneurysm patientsAortic aneurysmAortic riskFate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Wu J, Zafar M, Liu Y, Chen J, Li Y, Ziganshin B, Ellauzi H, Mukherjee S, Rizzo J, Elefteriades J. Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University. European Heart Journal 2023, 44: 4579-4588. PMID: 36994934, DOI: 10.1093/eurheartj/ehad148.Peer-Reviewed Original ResearchConceptsAdverse aortic eventsThoracic aortic aneurysmAortic sizeAortic aneurysmCox regressionAortic growthRisk factorsSignificant independent risk factorsMultivariable Cox regressionIndependent risk factorCohort of patientsUnivariable Cox regressionSignificant protective factorAortic deathATAA patientsAortic eventsPrimary endpointSurgical interventionThree-decade experienceNatural historyYearly riskProtective factorsAneurysmsPatientsIntervention criteriaFull calcium jacket: Conservative management of a traumatic aortic injury
Tripathi R, Ellauzi H, Zafar M, Ziganshin B, Elefteriades J. Full calcium jacket: Conservative management of a traumatic aortic injury. Journal Of Vascular Surgery Cases And Innovative Techniques 2023, 9: 101132. PMID: 37139352, PMCID: PMC10149390, DOI: 10.1016/j.jvscit.2023.101132.Peer-Reviewed Original ResearchKIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection
Velasco J, Li Y, Ziganshin B, Zafar M, Rizzo J, Ma D, Zang H, Kalyanasundaram A, Elefteriades J. KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection. Genes 2023, 14: 252. PMID: 36833179, PMCID: PMC9956195, DOI: 10.3390/genes14020252.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic dissectionOdds ratioVariant statusArg allele carriersThoracic aortic dissectionOccurrence of ADAortic sizeArg alleleMarked adverse impactTAA patientsAortic aneurysmClinical assessmentSurgical decisionAllele carriersIncrease riskVariant patientsArg carriersPilot studyDissectionImportant intracellular functionsConfirmatory findingsPatientsAneurysmsPresent study
2022
The Genetics of Inheritable Aortic Diseases
Kalyanasundaram A, Elefteriades J. The Genetics of Inheritable Aortic Diseases. Current Cardiovascular Risk Reports 2022, 16: 13-24. DOI: 10.1007/s12170-022-00687-x.Peer-Reviewed Original ResearchAbdominal aortic aneurysmRisk factorsAortic diseaseAortic aneurysmPatient outcomesGene variantsTraditional cardiovascular risk factorsBetter long-term survivalCV risk factorsDevelopment of TAADCardiovascular risk factorsBetter patient outcomesLong-term survivalGeneral risk factorsPurpose of ReviewOverTGF-β pathwayEarly surgeryLipid metabolism pathwaysDefinitive treatmentAneurysmal diseaseAortic diameterProphylactic surgeryAggressive casesPatient-specific guidelinesAortic wall
2021
Ascending Aneurysms in Heart Transplant Patients A Rare Opportunity to Assess Heredity Versus Biological Environment
Anis O, Kopf G, Ziganshin B, Zafar M, Tranquilli M, Sieller R, Elefteriades J. Ascending Aneurysms in Heart Transplant Patients A Rare Opportunity to Assess Heredity Versus Biological Environment. JACC Case Reports 2021, 3: 1685-1689. PMID: 34766019, PMCID: PMC8571777, DOI: 10.1016/j.jaccas.2021.07.010.Peer-Reviewed Original ResearchA probabilistic and anisotropic failure metric for ascending thoracic aortic aneurysm risk assessment
Liu M, Liang L, Zou Q, Ismail Y, Lou X, Iannucci G, Chen E, Leshnower B, Elefteriades J, Sun W. A probabilistic and anisotropic failure metric for ascending thoracic aortic aneurysm risk assessment. Journal Of The Mechanics And Physics Of Solids 2021, 155: 104539. DOI: 10.1016/j.jmps.2021.104539.Peer-Reviewed Original ResearchATAA patientsAortic wallAortic tissue samplesThoracic aortic aneurysmAortic aneurysmAneurysm rupturePatientsRisk assessmentTissue samplesCharacteristic curveFailure metricsTsai-Hill failure criterionCT imagesRiskTensile failure testsMaximum principal stressRupture risk assessmentPrevious studiesAssessmentSimple Hepatic Cysts as Markers of Thoracic Aortic Disease
C K, BA Z, MA Z, J B, J E. Simple Hepatic Cysts as Markers of Thoracic Aortic Disease. Journal Of Disease Markers 2021, 6 DOI: 10.26420/jdismarkers.2021.1043.Peer-Reviewed Original ResearchThoracic aortic diseaseSimple hepatic cystsBovine aortic archBicuspid aortic valveSimple renal cystsPositive family historyMost patientsAortic diseaseHepatic cystsRetrospective studyAortic aneurysmAortic archAortic valveClinical markersHospital patientsFamily historyRenal cystsTAD patientsControl groupPatientsAneurysmsPrevalenceCystsDiseaseAdherence of Aortic Aneurysm to Chest Wall
Elefteriades J, Ziganshin B. Adherence of Aortic Aneurysm to Chest Wall. 2021, 115-116. DOI: 10.1007/978-3-030-78877-3_42.Peer-Reviewed Original ResearchStand-Alone Elephant Trunk Procedure
Elefteriades J, Ziganshin B. Stand-Alone Elephant Trunk Procedure. 2021, 185-186. DOI: 10.1007/978-3-030-78877-3_59.Peer-Reviewed Original Research
2019
Mechanics of the Thoracic Aortic Wall
Ziganshin B, Elefteriades J. Mechanics of the Thoracic Aortic Wall. 2019, 149-162. DOI: 10.1007/978-3-7091-4874-7_10.Peer-Reviewed Original Research
2018
Genetic testing to modulate when to operate in thoracic aortic disease
Kostiuk V, Brownstein A, Ziganshin B, Elefteriades J. Genetic testing to modulate when to operate in thoracic aortic disease. Journal Of Visualized Surgery 2018, 4: 193-193. DOI: 10.21037/jovs.2018.07.14.Peer-Reviewed Original ResearchMolecular geneticsThoracic aortic aneurysmSurgical treatment optionsNon-syndromic thoracic aortic aneurysmsMolecular profilingSmooth muscle cell functionFamilial thoracic aortic aneurysmsMultiple genesSpecific genesMuscle cell functionTAA patientsTreatment optionsExtracellular matrixCell functionThoracic aortic diseaseGenesPositive family historyGeneticsProfilingTAA developmentAortic diseaseAortic aneurysmCurrent classificationDisease progressionFamily historyTime to Move to Earlier Intervention for Thoracic Aortic Aneurysm?
Gryaznov A, Ziganshin B, Elefteriades J. Time to Move to Earlier Intervention for Thoracic Aortic Aneurysm? Structural Heart 2018, 2: 10-22. DOI: 10.1080/24748706.2017.1404664.Peer-Reviewed Original ResearchThoracic aortic aneurysmBody surface areaAortic aneurysmMost life-threatening complicationsAortic growth rateEarly prophylactic interventionAcute aortic dissectionLife-threatening complicationsPatient/yearProphylactic surgical interventionSpecific genetic aberrationsAortic dissectionAortic sizeAortic diseaseCurrent gold standardSurgical interventionPatient heightProphylactic interventionsThoracic aortaAneurysm diseaseCommon causeFamily historyEarly diagnosisEarly interventionGenetic aberrationsChapter 10 Guilt by Association Paradigm for Detection of Silent Aortic Aneurysms
Findlay R, Thompson O, Ziganshin B, Elefteriades J. Chapter 10 Guilt by Association Paradigm for Detection of Silent Aortic Aneurysms. 2018, 107-118. DOI: 10.1016/b978-0-12-809979-7.00010-9.Peer-Reviewed Original ResearchThoracic aortic aneurysmAortic aneurysmAortic diseaseGiant cell arteritisAortic arch abnormalitiesBicuspid aortic valveThoracic aortic diseaseAbdominal aortic aneurysmConnective tissue disordersCell arteritisClinical findingsHigh morbidityAortic valveIncidental findingArch abnormalitiesClinical markersFamily historyTissue disordersRenal cystsTAA developmentAneurysmsIntracranial aneurysmsEarly detectionDiseasePatients