2015
Million Veteran Program: A mega-biobank to study genetic influences on health and disease
Gaziano JM, Concato J, Brophy M, Fiore L, Pyarajan S, Breeling J, Whitbourne S, Deen J, Shannon C, Humphries D, Guarino P, Aslan M, Anderson D, LaFleur R, Hammond T, Schaa K, Moser J, Huang G, Muralidhar S, Przygodzki R, O'Leary TJ. Million Veteran Program: A mega-biobank to study genetic influences on health and disease. Journal Of Clinical Epidemiology 2015, 70: 214-223. PMID: 26441289, DOI: 10.1016/j.jclinepi.2015.09.016.Peer-Reviewed Original ResearchConceptsMillion Veteran ProgramVeterans Affairs Health Care SystemObservational cohort studyVA electronic health recordVeteran ProgramHealth care deliverySelf-reported raceHealth care systemElectronic health recordsCohort studyAfrican American populationBlood samplesPeer-reviewed research studiesCare deliveryClinical decisionGenetic testingStudy designRecruiting sitesCare systemHealth recordsMost participantsPrecision medicineGenetic influencesAmerican populationParticipants
2013
Probability, uncertainty, and prostate cancer.
Concato J. Probability, uncertainty, and prostate cancer. Annals Of Internal Medicine 2013, 158: 211-212. PMID: 23381041, DOI: 10.7326/0003-4819-158-3-201302050-00012.Peer-Reviewed Original Research
2006
The Effectiveness of Screening for Prostate Cancer: A Nested Case-Control Study
Concato J, Wells CK, Horwitz RI, Penson D, Fincke G, Berlowitz DR, Froehlich G, Blake D, Vickers MA, Gehr GA, Raheb NH, Sullivan G, Peduzzi P. The Effectiveness of Screening for Prostate Cancer: A Nested Case-Control Study. JAMA Internal Medicine 2006, 166: 38-43. PMID: 16401808, DOI: 10.1001/archinte.166.1.38.Peer-Reviewed Original ResearchConceptsDigital rectal examinationCase-control studyCause-specific mortalityCase patientsProstate cancerControl patientsNested Case-Control StudyProstate-specific antigen (PSA) testVeterans Affairs Medical CenterAssociation of screeningBenefits of screeningEffectiveness of screeningVeterans Affairs facilitiesVerbal informed consentEffectiveness of PSADRE screeningCause mortalityPSA testingSurvival benefitRectal examinationAntigen testMedical CenterAmbulatory carePatientsClinical practice
2005
Diagnosis, Evaluation, and Treatment of Childhood Obesity in Pediatric Practice
Dorsey KB, Wells C, Krumholz HM, Concato J. Diagnosis, Evaluation, and Treatment of Childhood Obesity in Pediatric Practice. JAMA Pediatrics 2005, 159: 632-638. PMID: 15996996, DOI: 10.1001/archpedi.159.7.632.Peer-Reviewed Original ResearchConceptsBody mass indexRisk of overweightHospital-based clinicsHealth maintenance visitsRate of diagnosisType of treatmentComorbid diseasesMass indexOverweight childrenChildhood obesityMedical recordsTreatment recommendationsHigh burdenPediatric practiceRoutine screeningOverweightClinical practiceMaintenance visitsDiagnosisEncounter notesFormal diagnosisTreatmentChildrenSingle-parent householdsRisk
2003
Hyperglycaemia in patients with acute ischaemic stroke: how often do we screen for undiagnosed diabetes?
Bravata D, Kim N, Concato J, Brass L. Hyperglycaemia in patients with acute ischaemic stroke: how often do we screen for undiagnosed diabetes? QJM 2003, 96: 491-497. PMID: 12881591, DOI: 10.1093/qjmed/hcg087.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeStroke patientsIschemic strokeUndiagnosed diabetesAcute ischemic stroke patientsOral glucose tolerance testingRetrospective medical record reviewPrevalence of hyperglycaemiaAcute stroke patientsAssociation of diabetesIschemic stroke patientsAcute stroke eventsGlucose tolerance testingMedical record reviewModifiable conditionsDiabetes mellitusHemoglobin A1cHyperglycaemic patientsStroke eventsPrior diagnosisRecord reviewPrevious diagnosisClinicians screenConnecticut hospitalsTolerance testing
2001
Risk adjustment for older hospitalized persons A comparison of two methods of data collection for the Charlson index
van Doorn C, Bogardus S, Williams C, Concato J, Towle V, Inouye S. Risk adjustment for older hospitalized persons A comparison of two methods of data collection for the Charlson index. Journal Of Clinical Epidemiology 2001, 54: 694-701. PMID: 11438410, DOI: 10.1016/s0895-4356(00)00367-x.Peer-Reviewed Original ResearchConceptsICD-9 dataCharlson indexMortality predictionComorbid conditionsOlder general medical patientsYale-New Haven HospitalRisk adjustmentOriginal Charlson indexSpecific comorbid conditionsGeneral medical patientsGeneral medicine wardsHospital admission dateCharlson scoreIndividual comorbiditiesConsecutive patientsMedicine wardsClinical evidenceMedical patientsAdmission dateChart-based dataMortality riskICD-9PatientsChart dataLow agreementA nested case–control study of the effectiveness of screening for prostate cancer research design
Concato J, Peduzzi P, Kamina A, Horwitz R. A nested case–control study of the effectiveness of screening for prostate cancer research design. Journal Of Clinical Epidemiology 2001, 54: 558-564. PMID: 11377115, DOI: 10.1016/s0895-4356(00)00355-3.Peer-Reviewed Original ResearchInjury related infant death: the impact of race and birth weight
Jain A, Khoshnood B, Lee K, Concato J. Injury related infant death: the impact of race and birth weight. Injury Prevention 2001, 7: 135. PMID: 11428561, PMCID: PMC1730711, DOI: 10.1136/ip.7.2.135.Peer-Reviewed Original ResearchConceptsLow birthweight babiesBirth weightUnintentional injuriesRisk factorsOdds ratioSociodemographic factorsBirthweight babiesRisk of homicideInfant deathHigh riskImportant independent risk factorEffect of raceAfrican AmericansIndependent risk factorPreventable risk factorsAdjusted odds ratioRisk of deathMexican-American infantsLast pregnancyAlcohol intakePrenatal careMaternal ageMaternal raceInfant injuriesInfant's birthPreference for disclosure of information among patients with rheumatoid arthritis
Fraenkel L, Bogardus S, Concato J, Felson D. Preference for disclosure of information among patients with rheumatoid arthritis. Arthritis & Rheumatism 2001, 45: 136-139. PMID: 11324776, DOI: 10.1002/1529-0131(200104)45:2<136::aid-anr165>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisRA patientsSex-specific analysesSex-specific correlatesInformation preferencesPatient characteristicsTherapeutic optionsFemale sexSide effectsPatientsBivariate analysisHigher education levelCurrent employmentArthritisMean scoreEducation levelAlternative optionRiskFull disclosureOptionsMultiple linear regressionLinear regressionStepwise multiple linear regressionMedicationsRheumatologists
2000
Treatment Decisions for Localized Prostate Cancer
Holmboe E, Concato J. Treatment Decisions for Localized Prostate Cancer. Journal Of General Internal Medicine 2000, 15: 694-701. PMID: 11089712, PMCID: PMC1495597, DOI: 10.1046/j.1525-1497.2000.90842.x.Peer-Reviewed Original ResearchConceptsExternal beam radiationLocalized prostate cancerWatchful waitingProstate cancerRadical prostatectomyTreatment optionsTreatment decisionsCommon reasonPattern of complicationsPrimary care providersRemoval of tumorsLack of evidencePhysician recommendationConsecutive menCare providersHigh riskPatient decisionCancerLonger durationPractice groupMenBeam radiationTreatmentPatientsShort durationBeyond Diagnosis: Patient Mix and Challenges to Patient Care in Ambulatory Training Sites
Fiellin D, Concato J. Beyond Diagnosis: Patient Mix and Challenges to Patient Care in Ambulatory Training Sites. The American Journal Of The Medical Sciences 2000, 319: 106. PMID: 10698095, DOI: 10.1097/00000441-200002000-00007.Peer-Reviewed Original ResearchConceptsPrimary care centersAmbulatory training sitesPatient mixPatient-physician communicationVA Medical CenterCommon medical diagnosesInternal medicine residentsVA subjectsComorbidity scoreCare centerMedical CenterHealth statusPatient carePatient spectrumAmbulatory trainingPatientsMedicine residentsDiagnosisGroup practiceAmbulatory medicineCareTraining sitesMedical decisionsVA
1998
Physician Awareness of Alcohol Use Disorders Among Older Patients
Reid M, Tinetti M, Brown C, Concato J. Physician Awareness of Alcohol Use Disorders Among Older Patients. Journal Of General Internal Medicine 1998, 13: 729-734. PMID: 9824517, PMCID: PMC1497030, DOI: 10.1046/j.1525-1497.1998.00223.x.Peer-Reviewed Original ResearchConceptsAlcohol use disorderOlder patientsPrimary care physiciansInternal medicine physiciansCare physiciansPhysician awarenessMedicine physiciansUse disordersPrevalence estimatesPrimary care physicians' awarenessAnnual screening ratesQuantity-frequency questionsCross-sectional telephone surveyFamily practice physiciansGroup of physiciansCAGE questionsScreening ratesRegular screeningMiddle-aged physiciansPrevalence ratesPractice physiciansPhysician educationPatientsOlder physiciansBiochemical markersPrognostic Staging System for Recurrent, Persistent, and Second Primary Cancers of the Oral Cavity and Oropharynx
Yueh B, Feinstein A, Weaver E, Sasaki C, Concato J. Prognostic Staging System for Recurrent, Persistent, and Second Primary Cancers of the Oral Cavity and Oropharynx. JAMA Otolaryngology - Head & Neck Surgery 1998, 124: 975-981. PMID: 9738805, DOI: 10.1001/archotol.124.9.975.Peer-Reviewed Original ResearchConceptsStaging systemOral cavityRecurrent tumorsTNM stageWeight lossMajor prognostic importanceOne-year mortalityMortality of patientsSecond primary cancerSecond primary tumorsEvidence of recurrentPrognostic staging systemMedian survival timeSquamous cell tumorsAcademic medical centerComposite staging systemPractical staging systemTNM statusInception cohortMultivariable analysisOropharyngeal mucosaPrimary cancerRecurrent headMuscle invasionPrognostic importance
1997
Screening for Skin Cancer in Primary Care Settings
Federman D, Concato J, Caralis P, Hunkele G, Kirsner R. Screening for Skin Cancer in Primary Care Settings. JAMA Dermatology 1997, 133: 1423-1425. PMID: 9371027, DOI: 10.1001/archderm.1997.03890470101016.Peer-Reviewed Original ResearchConceptsPrimary care settingSkin examinationSkin cancerCare settingsFecal occult blood testingRetrospective observational cohort studyVeterans Affairs Medical CenterOccult blood testingObservational cohort studyPrimary care visitsMedical record reviewSkin cancer screeningOutpatient medical clinicSkin-related complaintsCare visitsCohort studyAmbulatory visitsRecord reviewRectal examinationBlood testingPhysical examinationCancer screeningProstate examinationMedical CenterMAIN OUTCOMEWhat Is a Screening Test?; SGIM Headquarters Change of Address
Concato J. What Is a Screening Test?; SGIM Headquarters Change of Address. Journal Of General Internal Medicine 1997, 12: 607-612. PMID: 9346456, PMCID: PMC1497171, DOI: 10.1046/j.1525-1497.1997.07120.x.Peer-Reviewed Original ResearchConceptsDigital rectal examinationCase-control studyOdds ratioObservational studyClinical distinctionCase controlWest Haven Veterans Affairs Medical CenterVeterans Affairs Medical CenterFrequency of screeningProportion of subjectsPrevalence of cancerDiagnosis of cancerPatient's symptomsRectal examinationProstate cancerMedical CenterCase subjectsScreening testCancerScreeningSubjectsSymptomsPrevalenceDiagnosisStudyAsking Patients What They Like: Overlooked Attributes of Patient Satisfaction with Primary Care
Concato J, Feinstein A. Asking Patients What They Like: Overlooked Attributes of Patient Satisfaction with Primary Care. The American Journal Of Medicine 1997, 102: 399-406. PMID: 9217623, DOI: 10.1016/s0002-9343(97)00092-2.Peer-Reviewed Original ResearchConceptsPatient satisfactionVeterans Affairs Medical CenterPrimary care clinicsPrimary health careHealth care servicesClinic visitsCare clinicsSame clinicOpen-ended questionsPrimary careClinimetric methodsMedical CenterPatientsCare servicesPhysician staffNonphysician staffClinicHealth careCareFace validityPsychometric instrumentsResponseSatisfactionCliniciansStaff
1996
Importance of cerebrovascular disease in studies of myocardial infarction.
Brass L, Hartigan P, Page W, Concato J. Importance of cerebrovascular disease in studies of myocardial infarction. Stroke 1996, 27: 1173-6. PMID: 8685923.Peer-Reviewed Original ResearchConceptsRate of strokeIschemic heart diseaseMyocardial infarctionHeart diseaseMonozygotic twinsManifestations of atherosclerosisWhite male veteransTwin pairsComplete responseTherapeutic trialsCerebrovascular diseaseHigh riskPrognostic studiesClinical investigationInfarctionMale veteransStrokeTwin RegistryStrong associationDiseaseOverall rateAtherosclerosisPatientsRegistryEnvironmental factorsFactors associated with successful implantation of nonthoracotomy defibrillation lead systems
Schwartzman D, Concato J, Ren J, Callans D, Gottlieb C, Preminger M, Marchlinski F. Factors associated with successful implantation of nonthoracotomy defibrillation lead systems. American Heart Journal 1996, 131: 1127-1136. PMID: 8644591, DOI: 10.1016/s0002-8703(96)90087-3.Peer-Reviewed Original ResearchConceptsNonthoracotomy defibrillation lead systemsDefibrillation lead systemsClinical factorsDefibrillation thresholdImplantation failureBiphasic shock waveformLead-related factorsShock waveformHigh defibrillation thresholdMonophasic shock waveformsLower defibrillation thresholdLead systemMonophasic groupConsecutive patientsBiphasic groupIncidence of successEndovascular SystemPatientsSuccessful implantationIncidenceImplantationFailureFactorsGroup
1995
Sex differences in the management of patients hospitalized with ischemic cerebrovascular disease.
Patrick S, Concato J, Viscoli C, Chyatte D, Brass L. Sex differences in the management of patients hospitalized with ischemic cerebrovascular disease. Stroke 1995, 26: 577-80. PMID: 7709400, DOI: 10.1161/01.str.26.4.577.Peer-Reviewed Original ResearchConceptsAge-adjusted odds ratioIschemic cerebrovascular diseaseArtery diseaseCerebrovascular diseaseOdds ratioCoronary artery diseaseManagement of patientsCarotid artery diseaseUse of angiographyAge-adjusted ratesSex differencesCerebral angiographyCarotid diseaseMale patientsCarotid endarterectomyConnecticut hospitalsEndarterectomyDisease typePatientsAngiographyDiseaseWomenMenBiological differencesSex
1993
Therapies for Benign Prostatic Hyperplasia
Concato J, Horwitz R, Feinstein A, Elmore J, Schiff S. Therapies for Benign Prostatic Hyperplasia. JAMA 1993, 269: 867-867. PMID: 7678874, DOI: 10.1001/jama.1993.03500070047017.Peer-Reviewed Original ResearchConceptsBenign prostatic hyperplasiaProstatic hyperplasiaOpen prostatectomyHigh mortalityYale-New Haven HospitalSurvival of patientsTime of surgeryT-testStudent's t-testTransurethral resectionTrial investigatorsTURPMortalityHyperplasiaPatientsProstatectomyResectionSurgeryHospitalTherapyProstateTrials