2003
Integrating the Molecular and Cellular Basis of Odor Coding in the Drosophila Antenna
Dobritsa AA, van Naters W, Warr CG, Steinbrecht RA, Carlson JR. Integrating the Molecular and Cellular Basis of Odor Coding in the Drosophila Antenna. Neuron 2003, 37: 827-841. PMID: 12628173, DOI: 10.1016/s0896-6273(03)00094-1.Peer-Reviewed Original ResearchConceptsAb3A neuronsEctopic expressionTransgenic rescue experimentsWild-type cellsDrosophila olfactory systemOdor ligandsDeletion mutantsDrosophila antennaCells identifiesGene expressionRescue experimentsCellular mapsSexual dimorphismReceptor gene expressionCellular basisOr22aOdor receptorsReceptor geneSingle cellsGenesOlfactory systemExpressionOdor codingDendritic membraneCells
2000
Candidate Taste Receptors in Drosophila
Clyne P, Warr C, Carlson J. Candidate Taste Receptors in Drosophila. Science 2000, 287: 1830-1834. PMID: 10710312, DOI: 10.1126/science.287.5459.1830.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAlternative SplicingAmino Acid SequenceAnimalsChemoreceptor CellsDrosophila melanogasterDrosophila ProteinsExonsGene ExpressionGenes, InsectIn Situ HybridizationInsect ProteinsMembrane ProteinsMolecular Sequence DataMultigene FamilyNeurons, AfferentOrgan SpecificityProtein Structure, TertiaryReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionSense OrgansSequence AlignmentTasteConceptsDrosophila genome databaseTransmembrane domain proteinCandidate taste receptorsDomain proteinsDrosophila mutantsDivergent familiesGenome databaseTaste receptorsTissue specificityMolecular mechanismsDiverse familyGustatory organsGenesStructural similarityLabellumBasis of structureTaste signalingProteinTaste neuronsInitial eventFamilyExpressionDrosophilaMutantsReceptors
1999
A Novel Family of Divergent Seven-Transmembrane Proteins Candidate Odorant Receptors in Drosophila
Clyne P, Warr C, Freeman M, Lessing D, Kim J, Carlson J. A Novel Family of Divergent Seven-Transmembrane Proteins Candidate Odorant Receptors in Drosophila. Neuron 1999, 22: 327-338. PMID: 10069338, DOI: 10.1016/s0896-6273(00)81093-4.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsPOU domain transcription factorLarge multigene familyCandidate odorant receptorsTransmembrane domain proteinGenomic sequence databasesSubset of ORNsDomain proteinsMultigene familyAntennal developmentOdorant receptorsTranscription factorsSequence databasesInitiate expressionOlfactory organOdorant specificityNovel familyDifferent membersReceptor neuronsReceptor moleculesInsectsMutantsValuable modelGenesOlfactory system