2016
Sex‐specific linkage scans in opioid dependence
Yang B, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex‐specific linkage scans in opioid dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 174: 261-268. PMID: 27762075, PMCID: PMC5695218, DOI: 10.1002/ajmg.b.32507.Peer-Reviewed Original ResearchAdultBlack or African AmericanBlack PeopleChromosome MappingCocaine-Related DisordersFemaleGenetic LinkageGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLod ScoreMaleMiddle AgedOpioid-Related DisordersPolymorphism, Single NucleotideRisk FactorsSex FactorsWhite People
2012
Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans
Han S, Gelernter J, Kranzler HR, Yang BZ. Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans. Human Genetics 2012, 132: 397-403. PMID: 23239122, PMCID: PMC3751162, DOI: 10.1007/s00439-012-1255-2.Peer-Reviewed Original ResearchAutosomal linkage scan for loci predisposing to comorbid dependence on multiple substances
Yang B, Han S, Kranzler HR, Farrer LA, Elston RC, Gelernter J. Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2012, 159B: 361-369. PMID: 22354695, PMCID: PMC3920832, DOI: 10.1002/ajmg.b.32037.Peer-Reviewed Original Research
2009
Genetics of alcohol dependence
Gelernter J, Kranzler HR. Genetics of alcohol dependence. Human Genetics 2009, 126: 91-99. PMID: 19533172, PMCID: PMC3773848, DOI: 10.1007/s00439-009-0701-2.Peer-Reviewed Original Research
2006
Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk Locus
Gelernter J, Panhuysen C, Weiss R, Brady K, Poling J, Krauthammer M, Farrer L, Kranzler HR. Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk Locus. Biological Psychiatry 2006, 61: 119-126. PMID: 17081504, DOI: 10.1016/j.biopsych.2006.08.023.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 5FemaleGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseHumansLod ScoreMaleMixed Function OxygenasesMultienzyme ComplexesNuclear FamilyPedigreePhenotypePolymorphism, Single NucleotideReproducibility of ResultsRetrospective StudiesTobacco Use DisorderConceptsRisk lociLinkage scanGenomewide linkage scanSignificant single-nucleotide polymorphism associationsGenetic linkage analysisSingle nucleotide polymorphism associationsHighest LOD scoreLinkage peakChromosome 5Linkage signalChromosome 7Small nuclear familiesLinkage analysisPeptidylglycine alphaLociLOD scoreDistinct populationsMultiple individualsGenesEA subjectsPhysiological hypothesisPolymorphism associationAA partEuropean AmericansGenomewide Linkage Scan for Opioid Dependence and Related Traits
Gelernter J, Panhuysen C, Wilcox M, Hesselbrock V, Rounsaville B, Poling J, Weiss R, Sonne S, Zhao H, Farrer L, Kranzler HR. Genomewide Linkage Scan for Opioid Dependence and Related Traits. American Journal Of Human Genetics 2006, 78: 759-769. PMID: 16642432, PMCID: PMC1474044, DOI: 10.1086/503631.Peer-Reviewed Original Research
2004
Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking
Gelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 128B: 94-101. PMID: 15211640, DOI: 10.1002/ajmg.b.30019.Peer-Reviewed Original ResearchGenomic regions controlling corticosterone levels in rats
Potenza MN, Brodkin ES, Joe B, Luo X, Remmers EF, Wilder RL, Nestler EJ, Gelernter J. Genomic regions controlling corticosterone levels in rats. Biological Psychiatry 2004, 55: 634-641. PMID: 15013833, DOI: 10.1016/j.biopsych.2003.11.005.Peer-Reviewed Original ResearchConceptsGenomic regionsQuantitative trait locus (QTL) analysisGenome-wide levelSpecific genomic regionsUnderstanding of susceptibilitySignificant QTLGenomic backgroundChromosome 4Locus analysisF2 progenyGenetic differencesSuggestive significanceDisease susceptibilityQTLFirst identificationCongenic animalsDeoxyribonucleic acidGenetic factorsProgenyIdentificationRegionSusceptibilityLevels
2001
Linkage genome scan for loci predisposing to panic disorder or agoraphobia
Gelernter J, Bonvicini K, Page G, Woods S, Goddard A, Kruger S, Pauls D, Goodson S. Linkage genome scan for loci predisposing to panic disorder or agoraphobia. American Journal Of Medical Genetics 2001, 105: 548-557. PMID: 11496373, DOI: 10.1002/ajmg.1496.Peer-Reviewed Original ResearchMeSH KeywordsAgoraphobiaChromosome MappingChromosomes, Human, Pair 1Chromosomes, Human, Pair 11Chromosomes, Human, Pair 14Chromosomes, Human, Pair 3Chromosomes, Human, Pair 4Family HealthFemaleGenetic Predisposition to DiseaseGenome, HumanHumansLod ScoreMaleMicrosatellite RepeatsPanic DisorderPedigreeConceptsLinkage genome scanGenome scanChromosome 3LOD scoreSuggestive linkagePrevious genome scanComplex traitsGenomic regionsHeritable anxiety disordersGenetic lociMultipoint LOD scoreCandidate genesRisk lociChromosome 1Chromosome 11pSusceptibility lociLociStatistical supportLinkage resultsNPL analysisPotential lociNPL scoreAmerican pedigreesSingle familyPotential linkage
1995
Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome
Gelernter J, Rao P, Pauls D, Hamblin M, Sibley D, Kidd K. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome. Genomics 1995, 26: 207-209. PMID: 7601444, DOI: 10.1016/0888-7543(95)80202-w.Peer-Reviewed Original ResearchConceptsGenetic linkageSomatic cell hybridsInteresting candidate genesPairwise linkage analysisCell hybridsNovel serotonin receptorCandidate genesChromosome 10Linkage analysisSouthern blotGenesExtended pedigreesLOD scoreReceptor geneLociGenetic polymorphismsHTR7PolymorphismReceptorsLIPED computer programDNALinkageHybridizationNeuropsychiatric disordersPedigree
1993
Exclusion of close linkage of Tourette's syndrome to D1 dopamine receptor
Gelernter J, Kennedy JL, Grandy DK, Zhou QY, Civelli O, Pauls DL, Pakstis A, Kurlan R, Sunahara RK, Niznik HB. Exclusion of close linkage of Tourette's syndrome to D1 dopamine receptor. American Journal Of Psychiatry 1993, 150: 449-453. PMID: 8434661, DOI: 10.1176/ajp.150.3.449.Peer-Reviewed Original Research
1992
The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS
Gelernter J, Kennedy JL, van Tol H, Civelli O, Kidd KK. The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 1992, 13: 208-210. PMID: 1349574, DOI: 10.1016/0888-7543(92)90222-e.Peer-Reviewed Original Research
1991
No Linkage Between D2 Dopamine Receptor Gene Region and Schizophrenia
Moises H, Gelernter J, Giuffra L, Zarcone V, Wetterberg L, Civelli O, Kidd K, Cavalli-Sforza L, Grandy D, Kennedy J, Vinogradov S, Mauer J, Litt M, Sjögren B. No Linkage Between D2 Dopamine Receptor Gene Region and Schizophrenia. JAMA Psychiatry 1991, 48: 643-647. PMID: 2069495, DOI: 10.1001/archpsyc.1991.01810310061011.Peer-Reviewed Original ResearchParallelizing genetic linkage analysis: A case study for applying parallel computation in molecular biology
Miller P, Nadkarni P, Gelernter J, Carriero N, Pakstis A, Kidd K. Parallelizing genetic linkage analysis: A case study for applying parallel computation in molecular biology. Journal Of Biomedical Informatics 1991, 24: 234-248. PMID: 1868693, DOI: 10.1016/0010-4809(91)90046-y.Peer-Reviewed Original ResearchConceptsParallel computersSequential programsMachine-independent parallel programming languageParallel programming languageDifferent parallel machinesLengthy computation timeParallel programsProgramming languageAvailable processorsDifferent processorsParallel computationParallel machinesSequential versionParallel versionComputational loadComputation timePerformance benchmarksComputerProcessorsCase studyDifferent piecesIterative programsLINKMAPComputationParallel forms
1990
Manic depressive illness not linked to factor IX region in an independent series of pedigrees
Gejman P, Detera-Wadleigh S, Martinez M, Berrettini W, Goldin L, Gelernter J, Hsieh W, Gershon E. Manic depressive illness not linked to factor IX region in an independent series of pedigrees. Genomics 1990, 8: 648-655. PMID: 1980485, DOI: 10.1016/0888-7543(90)90251-o.Peer-Reviewed Original ResearchGilles de la Tourette Syndrome Is Not Linked to D2-Dopamine Receptor
Gelernter J, Pakstis AJ, Pauls DL, Kurlan R, Gancher ST, Civelli O, Grandy D, Kidd KK. Gilles de la Tourette Syndrome Is Not Linked to D2-Dopamine Receptor. JAMA Psychiatry 1990, 47: 1073-1077. PMID: 1978653, DOI: 10.1001/archpsyc.1990.01810230089014.Peer-Reviewed Original ResearchX-Chromosome Markers and Manic-Depressive Illness: Rejection of Linkage to Xq28 in Nine Bipolar Pedigrees
Berrettini WH, Goldin LR, Gelernter J, Gejman PV, Gershon ES, Detera-Wadleigh S. X-Chromosome Markers and Manic-Depressive Illness: Rejection of Linkage to Xq28 in Nine Bipolar Pedigrees. JAMA Psychiatry 1990, 47: 366-373. PMID: 2322087, DOI: 10.1001/archpsyc.1990.01810160066010.Peer-Reviewed Original Research