2015
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence
Hancock DB, Reginsson GW, Gaddis NC, Chen X, Saccone NL, Lutz SM, Qaiser B, Sherva R, Steinberg S, Zink F, Stacey SN, Glasheen C, Chen J, Gu F, Frederiksen BN, Loukola A, Gudbjartsson DF, Brüske I, Landi MT, Bickeböller H, Madden P, Farrer L, Kaprio J, Kranzler HR, Gelernter J, Baker TB, Kraft P, Amos CI, Caporaso NE, Hokanson JE, Bierut LJ, Thorgeirsson TE, Johnson EO, Stefansson K. Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. Translational Psychiatry 2015, 5: e651-e651. PMID: 26440539, PMCID: PMC4930126, DOI: 10.1038/tp.2015.149.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesEuropean ancestry samplesNonsense-mediated decayWide significant associationsNicotinic receptor subunit geneReceptor subunit genesImportant regulatory propertiesNicotine dependenceSubunit geneAssociation studiesChromosome 20q13Regulatory propertiesLung cancer riskNovel variantsNormal human brainSmoking-related consequencesLung cancerCancer riskFagerström TestCHRNA4Smoking behaviorSignificant associationVariantsGenomeGenes
2003
A revised allele frequency estimate and haplotype analysis of the DBH deficiency mutation IVS1+2T → C in African‐ and European‐Americans
Zabetian CP, Romero R, Robertson D, Sharma S, Padbury JF, Kuivaniemi H, Kim K, Kim C, Köhnke MD, Kranzler HR, Gelernter J, Cubells JF. A revised allele frequency estimate and haplotype analysis of the DBH deficiency mutation IVS1+2T → C in African‐ and European‐Americans. American Journal Of Medical Genetics Part A 2003, 123A: 190-192. PMID: 14598346, DOI: 10.1002/ajmg.a.20300.Peer-Reviewed Original Research
2001
An in-frame deletion in the α2C adrenergic receptor is common in African–Americans
Feng J, Zheng J, Gelernter J, Kranzler H, Cook E, Goldman D, Jones IR, Craddock N, Heston LL, Delisi L, Peltonen L, Bennett WP, Sommer SS. An in-frame deletion in the α2C adrenergic receptor is common in African–Americans. Molecular Psychiatry 2001, 6: 168-172. PMID: 11317218, DOI: 10.1038/sj.mp.4000817.Peer-Reviewed Original Research