2015
Evidence of CNIH3 involvement in opioid dependence
Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH, Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW. Evidence of CNIH3 involvement in opioid dependence. Molecular Psychiatry 2015, 21: 608-614. PMID: 26239289, PMCID: PMC4740268, DOI: 10.1038/mp.2015.102.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsGenome-wide association studiesComputational genetic analysisEpigenetic annotationsGenetic analysisAssociation studiesGenetic studiesStudy of AddictionVivo functionalityMouse strainsOpioid dependenceNeurogenetics StudySevere addictive disordersΑ-aminoGenesOpioid misusersGeneticsCnih3SNPsDuke Neurogenetics StudyHaplotypesPhenotypeA alleleAllelesFetal brain
2002
Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in Depression
Cubells J, Zabetian C, Anderson G, Price L, Meyers B, Malison R, Nelson J, Nagatsu T, Ichinose H, Gelernter J. Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in Depression. Advances In Behavioral Biology 2002, 53: 423-426. DOI: 10.1007/978-1-4757-3538-3_101.Peer-Reviewed Original ResearchDβH proteinEnzyme activityMolecular genetic analysisBiochemical traitsGenetic analysisMajor locusNeurosecretory vesiclesGenetic inheritanceΒ-hydroxylaseDopamine β-hydroxylaseTraitsNeurosecretory cellsProteinDβH levelsConversion of dopamineLociVesiclesPlasma dopamine β-hydroxylaseInheritanceMembraneActivityCells