2015
Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis
Nevius E, Pinho F, Dhodapkar M, Jin H, Nadrah K, Horowitz MC, Kikuta J, Ishii M, Pereira JP. Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. Journal Of Experimental Medicine 2015, 212: 1931-1946. PMID: 26438360, PMCID: PMC4612084, DOI: 10.1084/jem.20150088.Peer-Reviewed Original ResearchConceptsOC precursorsBone surfaceEstrogen deficiency-induced osteoporosisBone mass homeostasisCell-cell interactionsTime-lapse microscopyBone metastatic cancerSignificant therapeutic potentialOxysterol ligandsFemale miceMale miceBone massMetastatic cancerLarge osteoclastsEBI2Nonhematopoietic cellsNovel pathwayTherapeutic potentialOsteoclastsTwo-photon microscopyMiceOsteoblastsVivoCellsOsteoporosis
2011
Oxysterols direct immune cell migration via EBI2
Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, Noël S, Gessier F, Kelly LM, Vanek M, Laurent S, Preuss I, Miault C, Christen I, Karuna R, Li W, Koo DI, Suply T, Schmedt C, Peters EC, Falchetto R, Katopodis A, Spanka C, Roy MO, Detheux M, Chen YA, Schultz PG, Cho CY, Seuwen K, Cyster JG, Sailer AW. Oxysterols direct immune cell migration via EBI2. Nature 2011, 475: 524-527. PMID: 21796212, PMCID: PMC4297623, DOI: 10.1038/nature10280.Peer-Reviewed Original Research