1984
The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs.
Wolin SL, Steitz JA. The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 1996-2000. PMID: 6201849, PMCID: PMC345423, DOI: 10.1073/pnas.81.7.1996.Peer-Reviewed Original ResearchConceptsRibonucleoprotein particleHeLa cellsSmall cytoplasmic RNARibonuclease protection experimentsSmall ribonucleoprotein particlesSmall cytoplasmic ribonucleoproteinsHuman HeLa cellsCytoplasmic ribonucleoproteinMammalian speciesCytoplasmic RNARNA sequencesMajor proteinsRo RNAsProtection experimentsRo proteinPossible functionsBase pairsIdentical base pairsRNAProteinSystemic lupus erythematosusAntigenic proteinsAntigenic polypeptidesRo antibodiesLupus erythematosus
1983
Sequential association of nucleolar 7-2 RNA with two different autoantigens.
Hashimoto C, Steitz JA. Sequential association of nucleolar 7-2 RNA with two different autoantigens. Journal Of Biological Chemistry 1983, 258: 1379-1382. PMID: 6185483, DOI: 10.1016/s0021-9258(18)32990-9.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAnti-La antibodiesLupus erythematosusDifferent autoantigensRo RNAsPattern of sensitivityTh 7
1982
Antibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles.
Hardin JA, Rahn DR, Shen C, Lerner MR, Wolin SL, Rosa MD, Steitz JA. Antibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles. Journal Of Clinical Investigation 1982, 70: 141-147. PMID: 6806318, PMCID: PMC370236, DOI: 10.1172/jci110587.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus erythematosusRheumatoid arthritisPatient seraHepatitis B virus infectionB virus infectionPositive antinuclear antibodyRheumatic disease patientsJuvenile rheumatoid arthritisConnective tissue diseaseAntinuclear antibodiesSjögren's syndromeTissue diseaseDisease patientsAntigenic interrelationshipsSpecific subsetVirus infectionPatientsSuch seraMonoclonal immunoglobulin GImmunoglobulin GSerumAntibodiesAntigenic determinantsErythematosusSmall RNPs in eucaryotic cells
Hendrick J, Mount S, Rinke J, Wolin S, Rosa M, Gottlieb E, Lerner M, Steitz J. Small RNPs in eucaryotic cells. 1982, 321-328. DOI: 10.1007/978-1-349-06343-7_44.Peer-Reviewed Original ResearchSmall nuclear RNAAbundant small nuclear RNAsRNA-protein complexesEukaryotic cellsSmall RNAsSmall ribonucleoproteinSubcellular locationNuclear RNARNA componentU1 snRNPsEucaryotic cellsComponent RNARibonucleoproteinRNP particlesRNAInitial discoveryProteinPartial characterizationState of maturationSnRNPsCellsSystemic lupus erythematosusDiversityMaturationMetabolism
1981
Striking Similarities Are Exhibited by Two Small Epstein-Barr Virus-Encoded Ribonucleic Acids and the Adenovirus-Associated Ribonucleic Acids VAI and VAII
Rosa M, Gottlieb E, Lerner M, Steitz J. Striking Similarities Are Exhibited by Two Small Epstein-Barr Virus-Encoded Ribonucleic Acids and the Adenovirus-Associated Ribonucleic Acids VAI and VAII. Molecular And Cellular Biology 1981, 1: 785-796. DOI: 10.1128/mcb.1.9.785-796.1981.Peer-Reviewed Original ResearchStriking similarities are exhibited by two small Epstein-Barr virus-encoded ribonucleic acids and the adenovirus-associated ribonucleic acids VAI and VAII.
Rosa MD, Gottlieb E, Lerner MR, Steitz JA. Striking similarities are exhibited by two small Epstein-Barr virus-encoded ribonucleic acids and the adenovirus-associated ribonucleic acids VAI and VAII. Molecular And Cellular Biology 1981, 1: 785-796. PMID: 9279391, PMCID: PMC369362, DOI: 10.1128/mcb.1.9.785.Peer-Reviewed Original ResearchConceptsEBER-1EBER-2Epstein-Barr virus-encoded ribonucleic acidEBER genesEpstein-Barr virus genomeEBV deoxyribonucleic acidSystemic lupus erythematosusAnti-La antibodiesEcoRI J fragmentRibonucleic acidSmall ribonucleic acidsLupus erythematosusUninfected cellsEBERVirus genomeViral genomeErythematosusVaIITwo small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus.
Lerner MR, Andrews NC, Miller G, Steitz JA. Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1981, 78: 805-809. PMID: 6262773, PMCID: PMC319891, DOI: 10.1073/pnas.78.2.805.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus erythematosusEBER-1EBER-2EBV DNAB lymphocytesEpstein-Barr virus genomeEpstein-Barr virusNormal B lymphocytesEcoRI J fragmentT lymphocytesErythematosusLa antigenLymphocytesPrimate cellsHerpesvirus atelesExhibit sequence homologyAntibodiesPotential relationshipVirus genomeCell transformationCellsUninfected mammalian cellsRNAMammalian cells
1979
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus
Lerner M, Steitz J. Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1979, 76: 5495-5499. PMID: 316537, PMCID: PMC411675, DOI: 10.1073/pnas.76.11.5495.Peer-Reviewed Original ResearchConceptsSmall nuclear RNA moleculesNuclear extractsMouse Ehrlich ascites cellsSmall nuclear RNANuclear RNA moleculesSmall nuclear ribonucleoproteinNuclear RNP particlesMammalian nucleiVertebrate speciesNuclear RNANuclear ribonucleoproteinRNA moleculesSystemic lupus erythematosusDifferent polypeptidesEhrlich ascites cellsIdentical complementSpecific proteinsMajor polypeptidesRNP particlesMolecular identityPossible functionsNuclear processesNuclear RNPAnti-Sm seraVirtue of association