2018
Telomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factors
Jiao J, Watt G, Stevenson H, Calderone T, Fisher‐Hoch S, Ye Y, Wu X, Vierling J, Beretta L. Telomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factors. Hepatology Communications 2018, 2: 718-731. PMID: 29881823, PMCID: PMC5983165, DOI: 10.1002/hep4.1187.Peer-Reviewed Original ResearchEvidence of HCCHepatitis C virusReverse transcriptase mutationsCell-free DNAHepatocellular carcinomaMale patientsTranscriptase mutationsLong-term imaging surveillancePlasma cell-free DNAFrequent genetic alterationsAlcoholic cirrhosisCancer Genome AtlasImaging surveillanceT promoter mutationClinical parametersMale sexPoor prognosisC virusRisk factorsSimilar prevalenceEarly biomarkersFamily historyHigh prevalenceCirrhosisPatients
2017
Prevalence of Aflatoxin-associated TP53R249S mutation in Hepatocellular Carcinoma in Hispanics in South Texas
Jiao J, Niu W, Wang Y, Baggerly K, Ye Y, Wu X, Davenport D, Almeda J, Betancourt-Garcia M, Forse R, Stevenson H, Watt G, McCormick J, Fisher-Hoch S, Beretta L. Prevalence of Aflatoxin-associated TP53R249S mutation in Hepatocellular Carcinoma in Hispanics in South Texas. Cancer Prevention Research 2017, 11: 103-112. PMID: 29089331, PMCID: PMC5811406, DOI: 10.1158/1940-6207.capr-17-0235.Peer-Reviewed Original ResearchConceptsAdvanced fibrosisHepatocellular carcinomaCell-free DNAHCC patientsHispanic subjectsShorter overall survivalPlasma cell-free DNAAsian HCC patientsOverall survivalWorse prognosisAflatoxin exposureHigh incidenceCirrhosisHCC tumorsPromising biomarkerDietary exposureFibrosisYounger agePatientsDroplet digital PCRHispanicsSomatic mutationsFamily membersUpstream regulatorSubjects