Featured Publications
Morphogenesis and cell ordering in confined bacterial biofilms
Zhang Q, Li J, Nijjer J, Lu H, Kothari M, Alert R, Cohen T, Yan J. Morphogenesis and cell ordering in confined bacterial biofilms. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2107107118. PMID: 34330824, PMCID: PMC8346881, DOI: 10.1073/pnas.2107107118.Peer-Reviewed Original ResearchConceptsInherent developmental programsBiofilm-dwelling cellsBiofilm-forming speciesSingle-cell imagingDevelopmental programSpecific matrix componentsCell orderingBiofilm developmentSpherical biofilmsBacterial cellsCell communityExtracellular matrixBiofilm morphologyBacterial biofilmsBiophysical mechanismsMatrix componentsHost tissuesBiofilmsBiofilm growthStiff gelsCellsMorphogenesisMutagenesisSpeciesVibrio
2019
Mechanical instability and interfacial energy drive biofilm morphogenesis
Yan J, Fei C, Mao S, Moreau A, Wingreen NS, Košmrlj A, Stone HA, Bassler BL. Mechanical instability and interfacial energy drive biofilm morphogenesis. ELife 2019, 8: e43920. PMID: 30848725, PMCID: PMC6453567, DOI: 10.7554/elife.43920.Peer-Reviewed Original ResearchConceptsSurface-attached bacterial communityBiofilm morphogenesisMorphogenesis programHigher organismsBiofilm expansionDiversity of morphologiesBacterial communitiesBiofilm surface morphologyRegulatory componentsBiofilm formationBacterial biofilmsModel systemEssential constituentBiofilmsMorphogenesisMutagenesisQuantitative image analysisOrganismsDiversityVibrio