2022
Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases
Tong J, Chen B, Tan P, Kurpiewski S, Cai Z. Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases. Frontiers In Medicine 2022, 9: 1062432. PMID: 36438061, PMCID: PMC9685622, DOI: 10.3389/fmed.2022.1062432.Peer-Reviewed Original ResearchPositron emission tomographyCentral nervous systemCNS diseaseNeurological disordersCentral nervous system diseaseNoninvasive positron emission tomographyNervous system diseasesIntense DNA damagePlausible therapeutic targetTherapeutic responseInflammatory responseSystem diseasesTherapeutic targetNervous systemNeurological diseasesEmission tomographyDiseasePARP1/2 inhibitorsPoly (ADP-ribose) polymeraseExpression levelsImaging targetsDisordersDNA damagePARP1/2Inflammation
2021
A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: synthesis and preclinical characterization of [18F]SDM-16
Zheng C, Holden D, Zheng MQ, Pracitto R, Wilcox KC, Lindemann M, Felchner Z, Zhang L, Tong J, Fowles K, Finnema SJ, Nabulsi N, Carson RE, Huang Y, Cai Z. A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: synthesis and preclinical characterization of [18F]SDM-16. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 49: 1482-1496. PMID: 34761284, PMCID: PMC8940841, DOI: 10.1007/s00259-021-05597-5.Peer-Reviewed Original ResearchConceptsTest-retest variabilityVolume of distributionCentral nervous systemTime-activity curvesPET tracersCentrum semiovaleSynaptic vesicle protein 2AAbsolute test-retest variabilityWhole central nervous systemNonhuman primate brainPlasma free fractionBrain PET scansHigh specific bindingSpecific bindingNondisplaceable volumePlasma input functionNHP brainOne-tissue compartment modelArterial bloodRegional time-activity curvesPET scansNervous systemPrimate brainMonkey brainPreclinical characterization