2024
Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function
Seo J, Gaddis N, Patchen B, Xu J, Barr R, O’Connor G, Manichaikul A, Gharib S, Dupuis J, North K, Cassano P, Hancock D. Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function. American Journal Of Clinical Nutrition 2024, 119: 1227-1237. PMID: 38484975, PMCID: PMC11130669, DOI: 10.1016/j.ajcnut.2024.03.007.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide interactionsGWAS meta-analysesGenome-wide genotypingGenetic variant associationsPathway enrichment analysisGenetic architectureVariant associationsP38 MAPK pathwayAssociation studiesGene-environment interactionsBiological insightsGenetic variantsEnrichment analysisVariant signalsMeta-analyzed resultsMAPK pathwayBiological relevancePathwayForced vital capacityEvaluate interactive effectsMeta-analysesVariantsSmoking historyAssociated with FEV<sub>1</sub> an
2020
Genetically Determined Omega-3 Polyunsaturated Fatty Acids and Lung Function: A Mendelian Randomization Analysis
Patchen B, Xu J, Hancock D, Cassano P. Genetically Determined Omega-3 Polyunsaturated Fatty Acids and Lung Function: A Mendelian Randomization Analysis. Current Developments In Nutrition 2020, 4: nzaa061_101. PMCID: PMC7259102, DOI: 10.1093/cdn/nzaa061_101.Peer-Reviewed Original ResearchAssociated with FEV1Multivariable MRMendelian randomizationForced vital capacityHeart and Aging ResearchInverse variance weighted methodHealth training programsMendelian randomization analysisVariance weighted methodGenome-wide association dataImprove causal inferenceCross-sectional studyLung functionNational InstituteWald ratioDigestive and Kidney DiseasesSample MRUnivariable MREpidemiology ConsortiumUK BiobankResidual confoundingNational Institute of DiabetesRandomization analysisTraining programForced expiratory volume
2019
Positive Associations of Dietary Marine Omega-3 Polyunsaturated Fatty Acids with Lung Function: A Meta-analysis (P18-087-19)
Patchen B, Xu J, Barr R, van Eekelen E, Dupuis J, North K, Gharib S, Lahousse L, Lemaitre R, Manichaikul A, de Mutsert R, Houston D, Saccone N, Steffen L, Terzikhan N, Xu H, Wojczynski M, Hancock D, Cassano P. Positive Associations of Dietary Marine Omega-3 Polyunsaturated Fatty Acids with Lung Function: A Meta-analysis (P18-087-19). Current Developments In Nutrition 2019, 3: nzz039.p18-087-19. PMCID: PMC6579416, DOI: 10.1093/cdn/nzz039.p18-087-19.Peer-Reviewed Original ResearchForced vital capacityN-3 PUFAFormer smokersLung functionHeart and Aging ResearchMeta-analysisAlpha-linolenic acidDietary intakeFish intakeGenomic Epidemiology ConsortiumFixed-effect meta-analysisPositive associationAssociated with forced expiratory volumeAssociated with higher lung functionHigher forced vital capacityDocosahexaenoic acidSD higher intakeAssociated with FEV1Higher lung functionDocosapentaenoic acidEicosapentanoic acidMarine n-3 PUFADietary n-3 PUFASmoking status interactionAssociation of docosahexaenoic acid
2018
Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function
Xu J, Bartz T, Chittoor G, Eiriksdottir G, Manichaikul A, Sun F, Terzikhan N, Zhou X, Booth S, Brusselle G, de Boer I, Fornage M, Frazier-Wood A, Graff M, Gudnason V, Harris T, Hofman A, Hou R, Houston D, Jacobs D, Kritchevsky S, Latourelle J, Lemaitre R, Lutsey P, O’Connor G, Oelsner E, Pankow J, Psaty B, Rohde R, Rich S, Rotter J, Smith L, Stricker B, Voruganti V, Wang T, Zillikens M, Barr R, Dupuis J, Gharib S, Lahousse L, London S, North K, Smith A, Steffen L, Hancock D, Cassano P. Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. British Journal Of Nutrition 2018, 120: 1159-1170. PMID: 30205856, PMCID: PMC6263170, DOI: 10.1017/s0007114518002180.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAgingBlack or African AmericanBlack PeopleCross-Sectional StudiesFemaleForced Expiratory VolumeGenome, HumanHeartHeart DiseasesHumansLungLung DiseasesMaleMiddle AgedMolecular EpidemiologyProspective StudiesRegression AnalysisRespiratory Function TestsSmokingVital CapacityVitamin DWhite PeopleConceptsHeart and Aging ResearchForced vital capacityEuropean ancestryVitamin DNever smokersMeta-analysisAfrican ancestryHigher 25(OH)DPulmonary functionGenomic Epidemiology ConsortiumSerum 25-hydroxyvitamin DAssociation of serum vitamin DSerum vitamin DEpidemiology ConsortiumForced expiratory volumeEffect modificationFormer smokersSmoking statusSerum 25(OH)DVulnerable populationsAging researchSmokersEpidemiological studiesExpiratory volumeVital capacity
2017
Meta‐Analysis of the Association of Omega‐3 Fatty Acids Biomarkers with Pulmonary Function
Xu J, Bartz T, Eiriksdottir G, Frazier‐Wood A, Gudnason V, Lahousse L, Manichaikul A, Rohde R, Sun F, Terzikhan N, Zhou X, Barr R, Brusselle G, Dupuis J, Gharib S, London S, North K, Psaty B, Smith A, Steffen L, Hancock D, Cassano P. Meta‐Analysis of the Association of Omega‐3 Fatty Acids Biomarkers with Pulmonary Function. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.167.5.Peer-Reviewed Original ResearchHigher forced vital capacityEA groupSmoking statusForced vital capacityNo significant associationMeta-analysisHeart and Aging ResearchEuropean ancestryAncestry groupsCohort-specific resultsFEV 1Genomic Epidemiology ConsortiumYears of cigarette smokingPopulation-based studyPlasma docosahexaenoic acidAfrican ancestryPulmonary function testsPulmonary functionEpidemiology ConsortiumEffect modificationNever smokersLinear regression modelsPack-yearsFEV 1 /FVCEffect estimates