Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model
Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC, Lombroso PJ. Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 19014-19019. PMID: 20956308, PMCID: PMC2973892, DOI: 10.1073/pnas.1013543107.Peer-Reviewed Original ResearchConceptsStriatal-enriched tyrosine phosphataseTyrosine phosphataseDisease mouse modelStriatal-enriched phosphataseAlzheimer's diseaseCellular deficitsGenetic manipulationNMDA receptorsMouse modelTriple transgenic AD mouse modelIncurable neurodegenerative disorderTransgenic AD mouse modelAlzheimer's disease mouse modelPathophysiology of ADSTEP inhibitorGenetic reductionAD mouse modelHuman AD patientsSoluble Aβ oligomersSynaptic functionPhosphataseNeurodegenerative disordersAD patientsDevastating disorderAnimal modelsA STEP forward in neural function and degeneration
Baum ML, Kurup P, Xu J, Lombroso PJ. A STEP forward in neural function and degeneration. Communicative & Integrative Biology 2010, 3: 419-422. PMID: 21057629, PMCID: PMC2974069, DOI: 10.4161/cib.3.5.12692.Peer-Reviewed Original ResearchStriatal-enriched phosphataseProtein tyrosine phosphataseTyrosine kinase FynMAP kinases ERK1/2Tyrosine phosphataseKinase FynLocal translationKinases ERK1/2NR1/NR2BProteolytic cleavageNormal regulationNeurodegenerative diseasesSubunitsSynaptic plasticityPhosphataseRegulationGluR2 receptorsNR2B subunitSynaptic strengtheningUbiquitinationRecent progressNeural functionFynPhosphorylationGluR2 subunit