2017
Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases
Tjin CC, Otley KD, Baguley TD, Kurup P, Xu J, Nairn AC, Lombroso PJ, Ellman JA. Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases. ACS Central Science 2017, 3: 1322-1328. PMID: 29296673, PMCID: PMC5746864, DOI: 10.1021/acscentsci.7b00486.Peer-Reviewed Original ResearchStriatal-enriched protein tyrosine phosphataseProtein tyrosineTyrosine phosphatasePhosphatase inhibitorProtein tyrosine phosphataseProtein tyrosine phosphorylation levelsActive site cysteineProtein tyrosine phosphorylationTyrosine phosphorylation levelsHuman PTPsSite cysteinePTP targetsTyrosine phosphorylationRepresentative cysteine proteaseCysteine proteasesHuman diseasesCellular activitiesPhosphorylation levelsVirulence factorsEssential roleSelective mechanismIntracellular GSH concentrationSelective active sitesNeurodegenerative diseasesPTP
2015
Striatal‐enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway
Xu J, Kurup P, Foscue E, Lombroso PJ. Striatal‐enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway. Journal Of Neurochemistry 2015, 134: 629-641. PMID: 25951993, PMCID: PMC4516628, DOI: 10.1111/jnc.13160.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphataseProtein kinase ARegulation of FynTyrosine phosphataseReceptor-type protein tyrosine phosphatase alphaProtein tyrosine phosphatase alphaStriatal-enriched protein tyrosine phosphataseRegulatory tyrosine residuesActivation of FynTyrosine kinase FynRegulatory tyrosineProtein tyrosinePTPαKinase FynSynaptic membranesKinase ATyrosine residuesFyn activityFynNovel substratePrimary neuronal culturesSTEP61Synergistic regulationMolecular techniquesNovel mechanism