A STEP forward in neural function and degeneration
Baum ML, Kurup P, Xu J, Lombroso PJ. A STEP forward in neural function and degeneration. Communicative & Integrative Biology 2010, 3: 419-422. PMID: 21057629, PMCID: PMC2974069, DOI: 10.4161/cib.3.5.12692.Peer-Reviewed Original ResearchStriatal-enriched phosphataseProtein tyrosine phosphataseTyrosine kinase FynMAP kinases ERK1/2Tyrosine phosphataseKinase FynLocal translationKinases ERK1/2NR1/NR2BProteolytic cleavageNormal regulationNeurodegenerative diseasesSubunitsSynaptic plasticityPhosphataseRegulationGluR2 receptorsNR2B subunitSynaptic strengtheningUbiquitinationRecent progressNeural functionFynPhosphorylationGluR2 subunitAβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61
Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ. Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61. Journal Of Neuroscience 2010, 30: 5948-5957. PMID: 20427654, PMCID: PMC2868326, DOI: 10.1523/jneurosci.0157-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCell LineCells, CulturedCerebral CortexEndocytosisHumansIn Vitro TechniquesMiceMice, KnockoutMice, TransgenicMiddle AgedNeuronsProtein Tyrosine Phosphatases, Non-ReceptorRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateUbiquitinated ProteinsUbiquitinationConceptsAlzheimer's diseaseAbeta treatmentNR2B subunitProtein tyrosine Phosphatase 61Cognitive deficitsNMDA receptor internalizationHuman AD brainsMouse cortical culturesNR1/NR2B receptorsNMDA receptor endocytosisIonotropic glutamate receptorsTyrosine phosphatase STEP61AD brainCortical slicesCortical culturesGlutamate receptorsNR2B receptorsPostsynaptic terminalsPrefrontal cortexNeuronal membranesElevated levelsCortexReceptor internalizationUbiquitin-proteasome systemStep activity