2011
Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity
Saavedra A, Giralt A, Rué L, Xifró X, Xu J, Ortega Z, Lucas JJ, Lombroso PJ, Alberch J, Pérez-Navarro E. Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity. Journal Of Neuroscience 2011, 31: 8150-8162. PMID: 21632937, PMCID: PMC3472648, DOI: 10.1523/jneurosci.3446-10.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCalcineurinCell DeathDisease Models, AnimalGene Expression RegulationGene Products, tatHuntingtin ProteinHuntington DiseaseMiceMice, Neurologic MutantsMice, TransgenicMicroinjectionsNerve Tissue ProteinsNuclear ProteinsPhosphorylationProtein Tyrosine Phosphatases, Non-ReceptorQuinolinic AcidSignal TransductionConceptsStriatal-enriched protein tyrosine phosphataseCell deathSTEP expressionPhosphorylation levelsProtein Tyrosine Phosphatase ExpressionProtein tyrosine phosphataseSTEP phosphorylationTyrosine phosphataseProtein kinasePhosphorylated ERK2Phosphatase expressionHuntington's diseaseSTEP proteinMutant huntingtinCalcineurin activityPhosphorylationExon 1STEP protein levelsDisease mouse modelProtein levelsMouse modelMouse striatumTAT-STEPHuntington's disease mouse modelExpression
2002
Cloning, expression and characterization of a novel human VMP gene*
Cheng C, Xu J, Ye X, Dai J, Wu Q, Zeng L, Wang L, Zhao W, Ji C, Gu S, Xie Y, Mao Y. Cloning, expression and characterization of a novel human VMP gene*. Molecular Biology Reports 2002, 29: 281-286. PMID: 12463420, DOI: 10.1023/a:1020402410522.Peer-Reviewed Original ResearchConceptsMembrane proteinsVesicular membrane proteinsNovel human genePutative molecular weightNeuron-specific membrane proteinMicrotubule-binding domainPutative membraneRT-PCR analysisHuman genesOrganelle transportVmp genesC-terminalAmino acidsCloningGenesProteinHydrophilic tailImportant roleCDNAMolecular weightMicrotubulesDomainKDaExpression
2001
Cloning, expression and characterization of a novel human REPS1 gene1The nucleotide sequence reported in this paper has been submitted to GenBank under accession number AF251052.1
Xu J, Zhou Z, Zeng L, Huang Y, Zhao W, Cheng C, Xu M, Xie Y, Mao Y. Cloning, expression and characterization of a novel human REPS1 gene1The nucleotide sequence reported in this paper has been submitted to GenBank under accession number AF251052.1. Biochimica Et Biophysica Acta 2001, 1522: 118-121. PMID: 11750063, DOI: 10.1016/s0167-4781(01)00310-4.Peer-Reviewed Original ResearchConceptsHuman fetal brain libraryFetal brain libraryAmino acid identitySignal transduction pathwaysDownstream target proteinsNorthern blot analysisProtein familySmall GTPaseBinding partnerAcid identityTransduction pathwaysNucleotide sequenceVariety of tissuesBrain libraryTarget proteinsReps1Blot analysisProteinRalBP1Recent findingsStrong expressionExpressionRalGTPaseImportant role