Featured Publications
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circulation Research 2022, 130: 1204-1229. PMID: 35420918, PMCID: PMC10032582, DOI: 10.1161/circresaha.121.319949.Peer-Reviewed Original ResearchConceptsMechanism of injuryIntracerebral hemorrhageUltra-early hemostatic therapyInflammatory brain injuryCurrent treatment strategiesIron-induced injuryAnticoagulant useHemostatic therapyHemorrhagic strokeHypertension managementICH therapySurgical managementHigh morbidityPrimary preventionFunctional outcomeICH managementBrain injuryClinical trialsTreatment strategiesPrognostic biomarkerDevastating formDisease pathobiologyInjuryInvasive surgeryOxidative stressImpacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage
Magid-Bernstein J, Beaman CB, Carvalho-Poyraz F, Boehme A, Hod EA, Francis RO, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Roh D. Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage. Blood 2021, 137: 2699-2703. PMID: 33649761, PMCID: PMC9635530, DOI: 10.1182/blood.2020008381.Peer-Reviewed Original ResearchConceptsABO-incompatible platelet transfusionsIntracerebral hemorrhagePlatelet transfusionsPlatelet recoveryABO-compatible transfusionsSingle-center cohortOdds of mortalityABO-incompatible transfusionLow platelet recoveryNeurological outcomeOngoing bleedingABO compatibilityICH outcomeMedication effectsTransfusionPoor mRSPatientsHemorrhageOutcomesUnderlying mechanismFurther investigationBleedingCohortMortalityRecoveryCerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials
Magid-Bernstein JR, Li Y, Cho SM, Piran PJ, Roh DJ, Gupta A, Shoamanesh A, Merkler A, Zhang C, Avadhani R, Montano N, Iadecola C, Falcone G, Sheth K, Qureshi AI, Rosand J, Goldstein J, Awad I, Hanley D, Kamel H, Ziai WC, Murthy SB. Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials. Neurology 2021, 98: e1013-e1020. PMID: 34937780, PMCID: PMC8967392, DOI: 10.1212/wnl.0000000000013247.Peer-Reviewed Original ResearchConceptsSmaller ICH volumeCerebral microbleedsSmall vessel diseaseIntracerebral hemorrhageHematoma expansionHematoma characteristicsICH volumeVessel diseaseNumber of CMBsSmaller baseline hematoma volumesUnderlying small vessel diseasePresence of CMBsCerebral small vessel diseaseAdmission ICH volumeMISTIE III trialPresence of microbleedsClass II evidencePhase 3 trialSeverity of leukoaraiosisPrimary intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataBrain MRI scansLogistic regression modelsAntihypertensive treatment
2024
Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage
Rivier C, Renedo D, Marini S, Magid‐Bernstein J, de Havenon A, Rosand J, Hanley D, Ziai W, Mayer S, Woo D, Sansing L, Sheth K, Anderson C, Falcone G. Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage. Annals Of Neurology 2024 PMID: 39499118, DOI: 10.1002/ana.27123.Peer-Reviewed Original ResearchRisk of hematoma expansionHighest risk of hematoma expansionRisk of poor outcomesIntracerebral hemorrhageHematoma expansionHigh riskMale sexPoor outcomeOutcome of spontaneous intracerebral hemorrhageClinical characteristics of patientsStudies of intracerebral hemorrhageNon-traumatic intracerebral hemorrhageIndividual patient data meta-analysisPatient data meta-analysisSpontaneous intracerebral hemorrhageSingle-center studyIntracerebral hemorrhage patientsHigh risk of expansionCharacteristics of patientsIntracerebral hemorrhage severityPoor functional outcomeRandomized clinical trialsData meta-analysisHemorrhage volumeClinical characteristics
2023
Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2021
Reversible Cerebral Vasoconstriction Syndrome
Magid-Bernstein J, Omran S, Parikh NS, Merkler AE, Navi B, Kamel H. Reversible Cerebral Vasoconstriction Syndrome. Neurology 2021, 97: e248-e253. PMID: 34050007, PMCID: PMC8302148, DOI: 10.1212/wnl.0000000000012223.Peer-Reviewed Original ResearchReversible cerebral vasoconstriction syndromeSex-standardized incidenceCerebral vasoconstriction syndromeHospital admissionNeurologic diagnosisPregnancy-related diagnosesIncidence of hospitalizationEmergency department visitsAdministrative dataIndex admissionED visitsIschemic strokeDepartment visitsIntracerebral hemorrhageCerebrovascular diseaseDischarge diagnosisSubarachnoid hemorrhagePopulation-wide dataCommunity hospitalAnnual ageUS adultsHealthcare costsPatientsAdmissionUtilization Project
2020
Red Blood Cell Transfusions and Outcomes After Intracerebral Hemorrhage
Roh DJ, Carvalho Poyraz F, Magid-Bernstein J, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Hod E, Murthy SB. Red Blood Cell Transfusions and Outcomes After Intracerebral Hemorrhage. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 105317. PMID: 32992186, PMCID: PMC7686150, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105317.Peer-Reviewed Original ResearchConceptsRBC transfusionICH outcomeDisease severityComorbidity burdenICH hospitalizationsPoor outcomeRed blood cell transfusionICD-9-CM codesBlood cell transfusionAdditional prospective studiesRed blood cell levelsIntracerebral hemorrhage outcomesNationwide Inpatient SampleLower red blood cell levelsBlood cell levelsBaseline comorbiditiesHospital mortalityTransfusion exposureVentriculostomy drainsCell transfusionLow comorbidityIntracerebral hemorrhageMechanical ventilationProspective studyInpatient Sample
2019
Low hemoglobin and hematoma expansion after intracerebral hemorrhage.
Roh DJ, Albers DJ, Magid-Bernstein J, Doyle K, Hod E, Eisenberger A, Murthy S, Witsch J, Park S, Agarwal S, Connolly ES, Elkind MSV, Claassen J. Low hemoglobin and hematoma expansion after intracerebral hemorrhage. Neurology 2019, 93: e372-e380. PMID: 31209179, PMCID: PMC6669932, DOI: 10.1212/wnl.0000000000007820.Peer-Reviewed Original ResearchConceptsAdmission hemoglobin levelsLower admission hemoglobin levelsLower hemoglobin levelsHemoglobin levelsHematoma expansionLower hemoglobinWorse outcomesMultivariable logistic regression modelSeparate multivariable logistic regression modelsPoor clinical outcomeMeeting inclusion criteriaIntracerebral hemorrhage volumeLogistic regression modelsAdmission hemoglobinRankin ScaleCohort studyConsecutive patientsClinical outcomesIntracerebral hemorrhagePoor outcomeICH outcomeICH scoreHemorrhage volumeModifiable targetsInclusion criteriaAdmission Hemoglobin Level is Associated with Hematoma Expansion and Poor Outcome after Intracerebral Hemorrhage (S2.001)
Magid-Bernstein J, Albers D, Doyle K, Hod E, Eisenberger A, Murthy S, Park S, Agarwal S, Connolly E, Elkind M, Claassen J, Roh D. Admission Hemoglobin Level is Associated with Hematoma Expansion and Poor Outcome after Intracerebral Hemorrhage (S2.001). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.s2.001.Peer-Reviewed Original ResearchAdmission hemoglobin levelsHemoglobin levelsIntracerebral hemorrhagePoor outcomeHematoma expansionHemorrhage