Clinical Pharmacokinetics of Anti-Parkinsonian Drugs
Cedarbaum J. Clinical Pharmacokinetics of Anti-Parkinsonian Drugs. Clinical Pharmacokinetics 1987, 13: 141-178. PMID: 3311529, DOI: 10.2165/00003088-198713030-00002.Peer-Reviewed Original ResearchConceptsAnti-parkinsonian agentsAnti-parkinsonian drugsClinical PharmacokineticsParkinson's diseaseDirect acting dopamine receptor agonistsLarge neutral amino acidsResponse fluctuationsAnti-parkinsonian actionLittle pharmacokinetic dataPharmacodynamics of levodopaTherapeutic response fluctuationsPlasma levodopa concentrationsDopamine receptor agonistsPotential drug toxicityClass of drugsMechanism of actionParkinsonian populationRenal functionPharmacokinetic considerationsUnchanged drugBrain uptakeReceptor agonistRenal excretionShort eliminationLevodopa concentrations