Featured Publications
Improved hypertension control at six months using an adapted WHO HEARTS-based implementation strategy at a large urban HIV clinic in Uganda
Muddu M, Semitala FC, Kimera I, Mbuliro M, Ssennyonjo R, Kigozi SP, Katwesigye R, Ayebare F, Namugenyi C, Mugabe F, Mutungi G, Longenecker CT, Katahoire AR, Ssinabulya I, Schwartz JI. Improved hypertension control at six months using an adapted WHO HEARTS-based implementation strategy at a large urban HIV clinic in Uganda. BMC Health Services Research 2022, 22: 699. PMID: 35610717, PMCID: PMC9131679, DOI: 10.1186/s12913-022-08045-8.Peer-Reviewed Original ResearchConceptsLarge urban HIV clinicUrban HIV clinicHTN outcomesHIV clinicHypertension controlViral suppressionHIV outcomesHTN treatmentFurther implementation researchHIV viral suppressionProportion of patientsPre-post studyVaried clinical settingsAdult PLHIVBP controlHTN controlHTN screeningCare cascadeHIV careLifestyle counselingClinic visitsDiastolic BPHIV controlIndependent predictorsSystolic BPImpact of a COVID-19 National Lockdown on Integrated Care for Hypertension and HIV
Schwartz JI, Muddu M, Kimera I, Mbuliro M, Ssennyonjo R, Ssinabulya I, Semitala FC. Impact of a COVID-19 National Lockdown on Integrated Care for Hypertension and HIV. Global Heart 2021, 16: 9. PMID: 33598389, PMCID: PMC7863843, DOI: 10.5334/gh.928.Peer-Reviewed Original ResearchConceptsHealth facilitiesPublic health facilitiesCOVID-19 national lockdownHTN controlHIV clinicUgandan patientsClinical outcomesChronic conditionsHypertensionIntegrated careHIVCOVID-19National lockdownMovement restrictionsMedicineNationwide lockdownOutcomesAntiretroviralsLockdownPatientsClinicCohortMotor vehicle transportationCareIntegrated Hypertension and HIV Care Cascades in an HIV Treatment Program in Eastern Uganda: A Retrospective Cohort Study.
Muddu M, Tusubira AK, Sharma SK, Akiteng AR, Ssinabulya I, Schwartz JI. Integrated Hypertension and HIV Care Cascades in an HIV Treatment Program in Eastern Uganda: A Retrospective Cohort Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 81: 552-561. PMID: 31045649, PMCID: PMC6625912, DOI: 10.1097/qai.0000000000002067.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyCare cascadeHIV careCohort studyHIV programsPrimary cardiovascular disease risk factorsCardiovascular disease risk factorsHIV care cascadeHIV care programsBlood pressure controlProportion of patientsDisease risk factorsHIV treatment programsViral load monitoringManagement of hypertensionHIV clinicEastern UgandaHIV treatmentRisk factorsCardiovascular diseaseHypertensionCare programPressure controlTreatment programHIV
2024
Time to blood pressure control and predictors among patients receiving integrated treatment for hypertension and HIV based on an adapted WHO HEARTS implementation strategy at a large urban HIV clinic in Uganda
Amutuhaire W, Semitala F, Kimera I, Namugenyi C, Mulindwa F, Ssenyonjo R, Katwesigye R, Mugabe F, Mutungi G, Ssinabulya I, Schwartz J, Katahoire A, Musoke L, Yendewa G, Longenecker C, Muddu M. Time to blood pressure control and predictors among patients receiving integrated treatment for hypertension and HIV based on an adapted WHO HEARTS implementation strategy at a large urban HIV clinic in Uganda. Journal Of Human Hypertension 2024, 38: 452-459. PMID: 38302611, PMCID: PMC11076202, DOI: 10.1038/s41371-024-00897-3.Peer-Reviewed Original ResearchBP controlDuo-therapyAmlodipine 5Blood pressureWorld Health OrganizationMono-therapyCox proportional hazards analysisUrban HIV clinicCox proportional hazards modelsProportional hazards analysisBlood pressure controlAnti-hypertensive treatmentStage I hypertensionHIV care settingsProportional hazards modelHypertensive PLHIVMonotherapy groupPill burdenHIV clinicCohort studySystolic BPHazards modelPressure controlPatientsMmHg
2023
Using the RE-AIM framework to evaluate the implementation and effectiveness of a WHO HEARTS-based intervention to integrate the management of hypertension into HIV care in Uganda: a process evaluation
Muddu M, Semitala F, Kimera I, Musimbaggo D, Mbuliro M, Ssennyonjo R, Kigozi S, Katwesigye R, Ayebare F, Namugenyi C, Mugabe F, Mutungi G, Longenecker C, Katahoire A, Schwartz J, Ssinabulya I. Using the RE-AIM framework to evaluate the implementation and effectiveness of a WHO HEARTS-based intervention to integrate the management of hypertension into HIV care in Uganda: a process evaluation. Implementation Science Communications 2023, 4: 102. PMID: 37626415, PMCID: PMC10463385, DOI: 10.1186/s43058-023-00488-2.Peer-Reviewed Original ResearchLarge HIV clinicManagement of hypertensionRE-AIM frameworkHIV careBlood pressureHeart interventionsHealthcare providersViral suppressionNational guidelinesTask shiftingHIV viral suppressionDiastolic blood pressureSystolic blood pressureOptimal viral suppressionTraining healthcare providersAdult PLHIVHIV clinicHypertension controlHypertension medicationsLifestyle counselingHIV outcomesHypertension managementClinic appointmentsMean ageMonth 21Diabetes mellitus care cascade among a cohort of persons living with HIV and hypertension in Uganda: A retrospective cohort study
Ambangira F, Sharman J, Muddu M, Kimera I, Namara D, Musimbaggo D, Namugenyi C, Ssenyonjo R, Mbuliro M, Katwesigye R, Schwartz J, Semitala F, Ssinabulya I. Diabetes mellitus care cascade among a cohort of persons living with HIV and hypertension in Uganda: A retrospective cohort study. International Journal Of STD & AIDS 2023, 34: 728-734. PMID: 37269360, DOI: 10.1177/09564624231179497.Peer-Reviewed Original ResearchConceptsDiabetes mellitusLarge urban HIV clinicNon-suppressed viral loadNon-communicable disease burdenUrban HIV clinicHIV care programsRetrospective cohort studyCohort of personsAppropriate diabetes careDiabetes mellitus careNon-communicable diseasesDual HIVCare cascadeHIV clinicCohort studyGlycaemic controlMedian ageViral loadRetrospective studyDiabetes careDisease burdenMellitus careCare programHIVHypertension
2022
Factors associated with blood pressure control in patients with hypertension and HIV at a large urban HIV clinic in Uganda
Musimbaggo D, Kimera I, Namugenyi C, Schwartz J, Ssenyonjo R, Ambangira F, Kizza L, Mbuliro M, Katwesigye R, Ssinabulya I, Muddu M, Neupane D, Olsen M, Pareek M, Semitala F. Factors associated with blood pressure control in patients with hypertension and HIV at a large urban HIV clinic in Uganda. Journal Of Human Hypertension 2022, 38: 345-351. PMID: 36476778, PMCID: PMC11001571, DOI: 10.1038/s41371-022-00786-7.Peer-Reviewed Original ResearchBlood pressure controlComorbid diabetes mellitusDiabetes mellitusPressure controlBlood pressureHIV statusCardiovascular diseaseLarge urban HIV clinicPoor blood pressure controlImportant preventable risk factorBlood pressure targetsIndividual HIV statusUrban HIV clinicPreventable risk factorsHIV status disclosureMultivariable logistic regressionAntihypertensive treatmentAntiretroviral therapyHIV clinicHypertension careSubpopulation of personsPressure targetsBaseline factorsHypertensive personsIntegrated HIVIntegrated multi-month dispensing of antihypertensive and antiretroviral therapy to sustain hypertension and HIV control
Kimera ID, Namugenyi C, Schwartz JI, Musimbaggo DJ, Ssenyonjo R, Atukunda P, Mutungi G, Mugabe F, Ambangira F, Mbuliro M, Katwesigye R, Neupane D, Ssinabulya I, Semitala FC, Delles C, Muddu M. Integrated multi-month dispensing of antihypertensive and antiretroviral therapy to sustain hypertension and HIV control. Journal Of Human Hypertension 2022, 37: 213-219. PMID: 35246602, PMCID: PMC8896410, DOI: 10.1038/s41371-022-00655-3.Peer-Reviewed Original ResearchConceptsHIV viral suppressionHypertension controlViral suppressionBlood pressureElevated systolic blood pressureHIV treatment outcomesMean blood pressureProportion of patientsSystolic blood pressureRetention of patientsPatient-centered approachAntiretroviral therapyHIV clinicStable patientsHIV controlHIV treatmentMean ageTreatment outcomesHypertensionPatientsHealthcare providersClinical encountersMonthsBaselineLongitudinal study
2021
Hypertension care cascade at a large urban HIV clinic in Uganda: a mixed methods study using the Capability, Opportunity, Motivation for Behavior change (COM-B) model
Muddu M, Ssinabulya I, Kigozi SP, Ssennyonjo R, Ayebare F, Katwesigye R, Mbuliro M, Kimera I, Longenecker CT, Kamya MR, Schwartz JI, Katahoire AR, Semitala FC. Hypertension care cascade at a large urban HIV clinic in Uganda: a mixed methods study using the Capability, Opportunity, Motivation for Behavior change (COM-B) model. Implementation Science Communications 2021, 2: 121. PMID: 34670624, PMCID: PMC8690902, DOI: 10.1186/s43058-021-00223-9.Peer-Reviewed Original ResearchAntiretroviral therapyHIV clinicHIV integrationCare cascadeHIV careHTN treatmentLarge urban HIV clinicART adherence counselingHypertension care cascadeLarge HIV clinicLow patient knowledgeUrban HIV clinicProportion of patientsAnti-hypertensive medicinesRisk of mortalityAdult PLHIVHTN careHTN complicationsHTN screeningConclusionThe prevalenceAdherence counselingMiddle-income countriesTreatment initiationPatient knowledgeBP machines