2023
Subacute combined degeneration of the spinal cord in a patient with nitrous oxide use and autoimmune atrophic gastritis
Gardin T, Yang A, Moeller J, Quraishi I. Subacute combined degeneration of the spinal cord in a patient with nitrous oxide use and autoimmune atrophic gastritis. BMJ Case Reports 2023, 16: e254727. PMID: 38035681, PMCID: PMC10689362, DOI: 10.1136/bcr-2023-254727.Peer-Reviewed Case Reports and Technical NotesConceptsAutoimmune atrophic gastritisNitrous oxide useAtrophic gastritisCombined degenerationSpinal cordRecreational nitrous oxide useSubacute combined degenerationVitamin B12 deficiencySubstance use disordersConcomitant etiologiesNeuropsychiatric manifestationsB12 deficiencyNeuropsychiatric sequelaePsychiatric comorbiditySecondary causesClinical pearlsDifferential diagnosisTimely treatmentUse disordersCommon drugsNutritional deficienciesVitamin B12Myelin sheathAlternative causesYoung adults
2021
The First 2 Years of Entrustment Decisions in the Core Entrustable Professional Activities (Core EPAs) Pilot
Brown DR, Moeller JJ, Grbic D, Andriole DA, Cutrer WB, Obeso VT, Hormann MD, Amiel JM. The First 2 Years of Entrustment Decisions in the Core Entrustable Professional Activities (Core EPAs) Pilot. Academic Medicine 2021, 96: s201-s202. PMID: 34705702, DOI: 10.1097/acm.0000000000004275.Peer-Reviewed Original Research
2017
Insights into teaching a complex skill: Threshold concepts and troublesome knowledge in electroencephalography (EEG)
Moeller JJ, Fawns T. Insights into teaching a complex skill: Threshold concepts and troublesome knowledge in electroencephalography (EEG). Medical Teacher 2017, 40: 387-394. PMID: 29216788, DOI: 10.1080/0142159x.2017.1408902.Peer-Reviewed Original ResearchConceptsThreshold concept frameworkThreshold conceptsTroublesome knowledgeConcept frameworkPotential threshold conceptsStudy of teachingLearners' understandingSemi-structured interviewsMedical educationComplex skillsThematic analysis approachTeachingInterview transcriptsPrior experienceTroublesome areasCore elementsKnowledgeDifficult areaLearnersEducationDifficult fieldLearningConceptSkillsExpertsFinding a Path to Entrustment in Undergraduate Medical Education
Brown DR, Warren JB, Hyderi A, Drusin RE, Moeller J, Rosenfeld M, Orlander PR, Yingling S, Call S, Terhune K, Bull J, Englander R, Wagner DP. Finding a Path to Entrustment in Undergraduate Medical Education. Academic Medicine 2017, 92: 774-779. PMID: 28557941, DOI: 10.1097/acm.0000000000001544.Peer-Reviewed Original ResearchConceptsUndergraduate medical educationMedical educationPilot schoolsEntrustment decisionsCore Entrustable Professional ActivitiesEntrustable professional activitiesSummative entrustment decisionsConcept of entrustmentLongitudinal performance assessmentPotential personal costsStart of residencyEntering ResidencyWorkplace supervisorsMedical schoolsMedical studentsProfessional activityRequisite knowledgeProfessional responsibilityStudentsSchoolsEducationMultiple assessorsEntrustmentConcept groupsNumber of questions
2015
Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome
Sivaraju A, Gilmore EJ, Wira CR, Stevens A, Rampal N, Moeller JJ, Greer DM, Hirsch LJ, Gaspard N. Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome. Intensive Care Medicine 2015, 41: 1264-1272. PMID: 25940963, DOI: 10.1007/s00134-015-3834-x.Peer-Reviewed Original ResearchConceptsBetter outcomesPoor outcomeEpileptiform dischargesPost-cardiac arrest comatose patientsCritical care EEG terminologyPost-cardiac arrest comaMethodsProspective cohort studyContinuous EEG monitoringLow-voltage EEGPositive predictive valueAbsence of reactivityEEG terminologyCohort studySpontaneous circulationBrainstem reflexesClinical outcomesComatose patientsFalse positive ratePoor prognosisPrognostic significanceSuppression burstsClinical variablesClinical correlatesElectroencephalographic patternsElectroencephalographic predictorsCross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use
Chen B, Detyniecki K, Hirsch LJ, Moeller J, Javed A, Kato K, Legge A, Buchsbaum R, Choi H. Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use. Epilepsy & Behavior 2015, 46: 151-157. PMID: 25935515, DOI: 10.1016/j.yebeh.2015.03.020.Peer-Reviewed Original ResearchConceptsAdverse cognitive effectsMore antiepileptic drugsAntiepileptic drugsAbsence seizure typesSpecific antiepileptic drugsAntiepileptic drug useMultiple antiepileptic drugsCertain antiepileptic drugsCognitive effectsHigh rateAED selectionClinical characteristicsIndependent predictorsSeizure typesSingle centerAED loadIndividual patientsPatientsDrug usePhenytoinIntolerabilityAED mechanismsLamotrigineVPAZNS
2014
Cosmetic side effects of antiepileptic drugs in adults with epilepsy
Chen B, Choi H, Hirsch L, Moeller J, Javed A, Kato K, Legge A, Buchsbaum R, Detyniecki K. Cosmetic side effects of antiepileptic drugs in adults with epilepsy. Epilepsy & Behavior 2014, 42: 129-137. PMID: 25513768, DOI: 10.1016/j.yebeh.2014.10.021.Peer-Reviewed Original ResearchConceptsCosmetic side effectsValproic acidSide effectsWeight gainGingival hyperplasiaHair lossPractice-based sampleMedication discontinuationAdult patientsDosage adjustmentFemale patientsNewer AEDsAntiepileptic drugsDifferent AEDsFemale sexMedical historyMedical recordsRisk factorsPhysician reportsAED usePatientsClinical practicePregabalinPatient recordsAEDs
2012
Refractory Status Epilepticus Associated with Anti-SSA (anti-Ro) Antibodies
Moeller JJ, Friedman D, Dugan P, Akman CI. Refractory Status Epilepticus Associated with Anti-SSA (anti-Ro) Antibodies. Canadian Journal Of Neurological Sciences / Journal Canadien Des Sciences Neurologiques 2012, 39: 660-663. PMID: 22931712, DOI: 10.1017/s0317167100015444.Peer-Reviewed Original Research
2011
Depiction of Seizure First Aid Management in Medical Television Dramas
Moeller AD, Moeller JJ, Rahey SR, Sadler RM. Depiction of Seizure First Aid Management in Medical Television Dramas. Canadian Journal Of Neurological Sciences / Journal Canadien Des Sciences Neurologiques 2011, 38: 723-727. PMID: 21856575, DOI: 10.1017/s0317167100054093.Peer-Reviewed Original ResearchConceptsFirst aid managementHealth care professionalsCare professionalsMedical television dramasPresence of seizuresAid managementSeizure first aidFirst aidAmerica guidelinesSeizure typesInvoluntary movementsSeizuresEpilepsy FoundationPerson's mouthInappropriate practicesGuidelinesMyoclonicManagementProfessionalsEtiologyMedical dramasMouth
2008
Lamotrigine–valproic acid combination therapy for medically refractory epilepsy
Moeller JJ, Rahey SR, Sadler RM. Lamotrigine–valproic acid combination therapy for medically refractory epilepsy. Epilepsia 2008, 50: 475-479. PMID: 19054403, DOI: 10.1111/j.1528-1167.2008.01866.x.Peer-Reviewed Original ResearchConceptsEpilepsy typeRefractory epilepsyAntiepileptic drugsCombination therapyPatient demographicsBaseline seizure frequencyRetrospective chart reviewPrimary outcome measureInclusion-exclusion criteriaVPA monotherapyChart reviewSeizure frequencyRetrospective studyMedical intractabilityClinic databaseUnimproved patientsOutcome measuresPatientsTherapyEpilepsyDemographicsSignificant differencesSeizuresMonthsSeverityDiagnostic Accuracy of Neurological Problems in the Emergency Department
Moeller JJ, Kurniawan J, Gubitz GJ, Ross JA, Bhan V. Diagnostic Accuracy of Neurological Problems in the Emergency Department. Canadian Journal Of Neurological Sciences / Journal Canadien Des Sciences Neurologiques 2008, 35: 335-341. PMID: 18714802, DOI: 10.1017/s0317167100008921.Peer-Reviewed Original ResearchConceptsInitial diagnosisNeurological consultationEmergency departmentFinal diagnosisPeripheral vertigoDiagnostic accuracyNeurological problemsTertiary care teaching hospitalBenign neurological conditionRetrospective chart reviewEmergency department settingBetter patient careChart reviewEmergent evaluationNeurological complaintsCommon misdiagnosesNeurology serviceEmergency referralsNeurocardiogenic syncopeSix-month periodDepartment settingPrimary headachesTeaching hospitalCommon conditionNeurological conditionsAutosomal dominant sensory ataxia: a neuroaxonal dystrophy
Moeller JJ, Macaulay RJ, Valdmanis PN, Weston LE, Rouleau GA, Dupré N. Autosomal dominant sensory ataxia: a neuroaxonal dystrophy. Acta Neuropathologica 2008, 116: 331-336. PMID: 18347805, DOI: 10.1007/s00401-008-0362-6.Peer-Reviewed Original ResearchConceptsDorsal column nucleiDorsal columnsSpinal cordAxonal spheroidsNeuroaxonal dystrophyPatchy chronic inflammationSkeletal muscleCongestive heart failureThoracolumbar spinal cordCentral sensory pathwaysPeripheral nerve rootsMajor pathological processesAutosomal dominant sensory ataxiaMicroglial activationClinical patternHeart failureNeuronal lossVentral hornCerebral cortexChronic inflammationNerve rootsPathological featuresWallerian degenerationPeripheral nervesSensory ataxia