2015
Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use
Chen B, Detyniecki K, Hirsch LJ, Moeller J, Javed A, Kato K, Legge A, Buchsbaum R, Choi H. Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use. Epilepsy & Behavior 2015, 46: 151-157. PMID: 25935515, DOI: 10.1016/j.yebeh.2015.03.020.Peer-Reviewed Original ResearchConceptsAdverse cognitive effectsMore antiepileptic drugsAntiepileptic drugsAbsence seizure typesSpecific antiepileptic drugsAntiepileptic drug useMultiple antiepileptic drugsCertain antiepileptic drugsCognitive effectsHigh rateAED selectionClinical characteristicsIndependent predictorsSeizure typesSingle centerAED loadIndividual patientsPatientsDrug usePhenytoinIntolerabilityAED mechanismsLamotrigineVPAZNS
2014
Cosmetic side effects of antiepileptic drugs in adults with epilepsy
Chen B, Choi H, Hirsch L, Moeller J, Javed A, Kato K, Legge A, Buchsbaum R, Detyniecki K. Cosmetic side effects of antiepileptic drugs in adults with epilepsy. Epilepsy & Behavior 2014, 42: 129-137. PMID: 25513768, DOI: 10.1016/j.yebeh.2014.10.021.Peer-Reviewed Original ResearchConceptsCosmetic side effectsValproic acidSide effectsWeight gainGingival hyperplasiaHair lossPractice-based sampleMedication discontinuationAdult patientsDosage adjustmentFemale patientsNewer AEDsAntiepileptic drugsDifferent AEDsFemale sexMedical historyMedical recordsRisk factorsPhysician reportsAED usePatientsClinical practicePregabalinPatient recordsAEDs
2008
Lamotrigine–valproic acid combination therapy for medically refractory epilepsy
Moeller JJ, Rahey SR, Sadler RM. Lamotrigine–valproic acid combination therapy for medically refractory epilepsy. Epilepsia 2008, 50: 475-479. PMID: 19054403, DOI: 10.1111/j.1528-1167.2008.01866.x.Peer-Reviewed Original ResearchConceptsEpilepsy typeRefractory epilepsyAntiepileptic drugsCombination therapyPatient demographicsBaseline seizure frequencyRetrospective chart reviewPrimary outcome measureInclusion-exclusion criteriaVPA monotherapyChart reviewSeizure frequencyRetrospective studyMedical intractabilityClinic databaseUnimproved patientsOutcome measuresPatientsTherapyEpilepsyDemographicsSignificant differencesSeizuresMonthsSeverity