β-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction
Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. β-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction. JAMA 2002, 288: 351-357. PMID: 12117400, DOI: 10.1001/jama.288.3.351.Peer-Reviewed Original ResearchConceptsBeta-blocker therapySexual dysfunctionDepressive symptomsSymptoms of depressionAdverse eventsHeart failureMyocardial infarctionSignificant annual increaseAdditional reportsLipid solubilityAdverse effectsWithdrawal of therapyΒ-blocker therapyPatient-reported symptomsNumber of patientsEnglish-language articlesInclusion of trialsPlacebo groupMortality benefitRandomized trialsStudy treatmentCardiac patientsPlacebo controlRisk of fatigueClinical trialsClinical trials do not support strong association of beta-blocker therapy with fatigue, depression, or sexual dysfunction
Ko D, Hebert P, Coffey C, Sedrakyan A, Curtis J, Krumholz H. Clinical trials do not support strong association of beta-blocker therapy with fatigue, depression, or sexual dysfunction. Journal Of The American College Of Cardiology 2002, 39: 440. DOI: 10.1016/s0735-1097(02)81978-7.Peer-Reviewed Original Research