2007
Impact of Delay in Door-to-Needle Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Herrin J, Wang Y, Curtis JP, Bradley EH, Magid DJ, Rathore SS, Nallamothu BK, Peterson ED, Blaney ME, Frederick P, Krumholz HM. Impact of Delay in Door-to-Needle Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. The American Journal Of Cardiology 2007, 100: 1227-1232. PMID: 17920362, PMCID: PMC2715362, DOI: 10.1016/j.amjcard.2007.05.043.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArrhythmias, CardiacCaliforniaCohort StudiesEmergency Service, HospitalEmergency TreatmentFemaleFibrinolytic AgentsHospital MortalityHumansMaleMedical RecordsMyocardial InfarctionOutcome Assessment, Health CareRegistriesRetrospective StudiesThrombolytic TherapyTime and Motion StudiesTime FactorsConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionNeedle timeFibrinolytic therapyMyocardial infarctionHospital mortalitySymptom onsetOdds ratioReperfusion strategyAdjunctive medicationsHospital arrivalShorter doorTimely administrationNational registryRepresentative cohortPatientsMortalityInfarctionTherapyIndependent effectsCohortMinutesSmaller centersOnsetImpact of delay
2006
Hospital Quality for Acute Myocardial Infarction: Correlation Among Process Measures and Relationship With Short-term Mortality
Bradley EH, Herrin J, Elbel B, McNamara RL, Magid DJ, Nallamothu BK, Wang Y, Normand SL, Spertus JA, Krumholz HM. Hospital Quality for Acute Myocardial Infarction: Correlation Among Process Measures and Relationship With Short-term Mortality. JAMA 2006, 296: 72-78. PMID: 16820549, DOI: 10.1001/jama.296.1.72.Peer-Reviewed Original ResearchMeSH KeywordsAgedCenters for Medicare and Medicaid Services, U.S.Cross-Sectional StudiesHospital MortalityHospitalsHumansJoint Commission on Accreditation of Healthcare OrganizationsMedicareMyocardial InfarctionOutcome and Process Assessment, Health CareQuality Indicators, Health CareRegistriesRisk AssessmentUnited StatesConceptsAcute myocardial infarctionMortality rateMyocardial infarctionProcess measuresAngiotensin-converting enzyme inhibitor useRisk-standardized mortality ratesShort-term mortality rateBeta-blocker useEnzyme inhibitor useHospital performanceHospital-level variationShort-term mortalityQuality process measuresAspirin useCessation counselingHospital outcomesInhibitor useAMI patientsNational registryMedication measuresTherapy measuresHospital qualityInfarctionMedicaid ServicesJoint CommissionDoor-to-drug and door-to-balloon times: Where can we improve? Time to reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI)
Bradley EH, Herrin J, Wang Y, McNamara RL, Radford MJ, Magid DJ, Canto JG, Blaney M, Krumholz HM. Door-to-drug and door-to-balloon times: Where can we improve? Time to reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI). American Heart Journal 2006, 151: 1281-1287. PMID: 16781237, DOI: 10.1016/j.ahj.2005.07.015.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPatients' clinical characteristicsBalloon timeClinical characteristicsDrug timeMyocardial infarctionProportion of patientsElevation myocardial infarctionHospital-level variationTreatment of patientsCross-sectional analysisHigh performing hospitalsReperfusion therapyNational registryHospitalPatientsRegression modelingECGDrugsInfarctionHierarchical regression modelingHospital performanceImportant quality indicatorMinutesGeometric meanEffect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Wang Y, Herrin J, Curtis JP, Bradley EH, Magid DJ, Peterson ED, Blaney M, Frederick PD, Krumholz HM, Investigators N. Effect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. Journal Of The American College Of Cardiology 2006, 47: 2180-2186. PMID: 16750682, DOI: 10.1016/j.jacc.2005.12.072.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionBalloon timeElevation myocardial infarctionSymptom onsetMyocardial infarctionHospital mortalityPatient characteristicsDoor timeEffect of doorPrimary PCIBaseline risk statusPercutaneous coronary interventionHigh-risk factorsSTEMI patientsCohort studyCoronary interventionLonger doorEntire cohortSubgroup analysisNational registryBaseline riskMortality riskPatientsMortalityThe Pre-Hospital Electrocardiogram and Time to Reperfusion in Patients With Acute Myocardial Infarction, 2000–2002 Findings From the National Registry of Myocardial Infarction-4
Curtis JP, Portnay EL, Wang Y, McNamara RL, Herrin J, Bradley EH, Magid DJ, Blaney ME, Canto JG, Krumholz HM. The Pre-Hospital Electrocardiogram and Time to Reperfusion in Patients With Acute Myocardial Infarction, 2000–2002 Findings From the National Registry of Myocardial Infarction-4. Journal Of The American College Of Cardiology 2006, 47: 1544-1552. PMID: 16630989, DOI: 10.1016/j.jacc.2005.10.077.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPre-hospital electrocardiogramPrimary percutaneous coronary interventionMyocardial infarction 4Mean doorReperfusion timeHospital characteristicsNational registryTreatment of STEMILimited contemporary informationElevation myocardial infarctionPercutaneous coronary interventionBundle branch blockAcute reperfusionECG usePCI cohortReperfusion therapyBalloon timeCoronary interventionFibrinolytic therapyTherapy cohortMyocardial infarctionBranch blockNational guidelinesDrug timeRelation Between Hospital Specialization With Primary Percutaneous Coronary Intervention and Clinical Outcomes in ST-Segment Elevation Myocardial Infarction
Nallamothu BK, Wang Y, Magid DJ, McNamara RL, Herrin J, Bradley EH, Bates ER, Pollack CV, Krumholz HM. Relation Between Hospital Specialization With Primary Percutaneous Coronary Intervention and Clinical Outcomes in ST-Segment Elevation Myocardial Infarction. Circulation 2006, 113: 222-229. PMID: 16401769, DOI: 10.1161/circulationaha.105.578195.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionHospital mortalityBalloon timePPCI volumeFibrinolytic therapyClinical outcomesMyocardial infarctionPrimary percutaneous coronary intervention capabilityPercutaneous coronary intervention capabilityPrimary percutaneous coronary interventionHierarchical multivariable regressionMyocardial infarction 4Hospital-level factorsPercutaneous coronary interventionHospital specializationSTEMI patientsCoronary interventionHighest quartileShorter doorHospital characteristicsNational registryLowest quartileRelative riskMultivariable regression
2005
Hospital Improvement in Time to Reperfusion in Patients With Acute Myocardial Infarction, 1999 to 2002
McNamara RL, Herrin J, Bradley EH, Portnay EL, Curtis JP, Wang Y, Magid DJ, Blaney M, Krumholz HM, Investigators N. Hospital Improvement in Time to Reperfusion in Patients With Acute Myocardial Infarction, 1999 to 2002. Journal Of The American College Of Cardiology 2005, 47: 45-51. PMID: 16386663, PMCID: PMC1475926, DOI: 10.1016/j.jacc.2005.04.071.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionBalloon timeMin/yearNeedle timeMyocardial infarctionHospital characteristicsAcute ST-segment elevation myocardial infarctionPercutaneous coronary intervention cohortPercutaneous coronary intervention volumeElevation myocardial infarctionPercutaneous coronary interventionRetrospective observational studyFour-year study periodRapid reperfusionCoronary interventionFibrinolytic therapyHospital arrivalTherapy cohortReperfusion timeIntervention cohortNational registryIntervention volumeObservational studyHospital improvementPatientsTimes to Treatment in Transfer Patients Undergoing Primary Percutaneous Coronary Intervention in the United States: National Registry of Myocardial Infarction (NRMI)-3/4 Analysis
Nallamothu B, Bates E, Herrin J. Times to Treatment in Transfer Patients Undergoing Primary Percutaneous Coronary Intervention in the United States: National Registry of Myocardial Infarction (NRMI)-3/4 Analysis. ACC Current Journal Review 2005, 14: 24. DOI: 10.1016/j.accreview.2005.05.053.Peer-Reviewed Original ResearchQuality Improvement Efforts and Hospital Performance
Bradley EH, Herrin J, Mattera JA, Holmboe ES, Wang Y, Frederick P, Roumanis SA, Radford MJ, Krumholz HM. Quality Improvement Efforts and Hospital Performance. Medical Care 2005, 43: 282-292. PMID: 15725985, DOI: 10.1097/00005650-200503000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overCross-Sectional StudiesDrug Utilization ReviewFemaleHospitalsHumansLeadershipMaleMedical Staff, HospitalMiddle AgedMyocardial InfarctionOrganizational CultureOutcome Assessment, Health CarePractice Patterns, Physicians'Quality Indicators, Health CareRegistriesTotal Quality ManagementUnited StatesConceptsAcute myocardial infarctionBeta-blocker prescription ratesQuality improvement effortsMyocardial infarctionBeta-blocker useHospital teaching statusCross-sectional studyQuality improvement interventionsPatient-level dataPhysician leadershipQuality of careHospital performanceHospital quality improvement effortsImprovement effortsQuality improvement strategiesPrescription ratesBorderline significanceNational registryAMI volumeUS hospitalsImprovement interventionsHospitalTeaching statusEvidence baseHigh/mediumTimes to Treatment in Transfer Patients Undergoing Primary Percutaneous Coronary Intervention in the United States
Nallamothu BK, Bates ER, Herrin J, Wang Y, Bradley EH, Krumholz HM. Times to Treatment in Transfer Patients Undergoing Primary Percutaneous Coronary Intervention in the United States. Circulation 2005, 111: 761-767. PMID: 15699253, DOI: 10.1161/01.cir.0000155258.44268.f8.Peer-Reviewed Original ResearchConceptsPrimary PCIPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionPercutaneous coronary interventionBalloon timeTransfer patientsCoronary interventionInterhospital transferMyocardial infarctionTotal doorRecent clinical trialsSpecific ECG findingsMultivariable hierarchical modelsChest painHospital presentationInitial hospitalFibrinolytic therapyPCI hospitalsPrimary outcomeSymptom onsetComorbid conditionsTreatment delayECG findingsHospital characteristicsNational registry
2004
Hospital-Level Performance Improvement
Bradley EH, Herrin J, Mattera JA, Holmboe ES, Wang Y, Frederick P, Roumanis SA, Radford MJ, Krumholz HM. Hospital-Level Performance Improvement. Medical Care 2004, 42: 591-599. PMID: 15167327, DOI: 10.1097/01.mlr.0000128006.27364.a9.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAmerican Hospital AssociationCardiology Service, HospitalComorbidityDrug Utilization ReviewFemaleGeographyGuideline AdherenceHealth Care SurveysHumansLogistic ModelsMaleMiddle AgedMyocardial InfarctionPatient DischargeQuality Assurance, Health CareRegistriesSocioeconomic FactorsUnited StatesConceptsBeta-blocker useAcute myocardial infarctionHospital-level variationHospital characteristicsMyocardial infarctionBeta-blocker prescription ratesHospital-level changesHospital-level ratesAmerican Hospital Association Annual SurveyClinical characteristicsPrescription ratesNational registryAMI volumeHospital ratesRate of improvementImprovement rateTeaching statusIndividual hospitalsInfarctionHospitalNational surveyPercentage pointsTime periodUse ratesWeak predictor
2003
What Are Hospitals Doing to Increase Beta-Blocker Use?
Bradley EH, Holmboe ES, Wang Y, Herrin J, Frederick PD, Mattera JA, Roumanis SA, Radford MJ, Krumholz HM. What Are Hospitals Doing to Increase Beta-Blocker Use? The Joint Commission Journal On Quality And Patient Safety 2003, 29: 409-415. PMID: 12953605, DOI: 10.1016/s1549-3741(03)29049-3.Peer-Reviewed Original ResearchConceptsBeta-blocker useQuality improvement interventionsMyocardial infarctionCare coordinatorsClinical pathwayImprovement interventionsAcute myocardial infarctionCross-sectional analysisQuality improvement staffQuality improvement effortsNational registryMedian numberHospitalTelephone surveyInfarctionReminder FormInterventionImprovement effortsRegistryPrevalencePathwayPhysicians