2021
Desmoplastic Trichoepithelioma With Pseudocarcinomatous Hyperplasia: A Folliculosebaceous Neoplasm in Young Persons
Wang MZ, McNiff JM, McCalmont TH, LeBoit PE. Desmoplastic Trichoepithelioma With Pseudocarcinomatous Hyperplasia: A Folliculosebaceous Neoplasm in Young Persons. American Journal Of Dermatopathology 2021, 43: 788-793. PMID: 33899770, DOI: 10.1097/dad.0000000000001922.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaCell carcinomaImmunohistochemical profileMorphoeic basal cell carcinomaSquamous cell carcinomaMicrocystic adnexal carcinomaBasal cell carcinomaFollicular germinative cellsMedian ageBer-EP4Clinical manifestationsAdnexal carcinomaMalignant neoplasmsFibrotic stromaBasaloid cellsEpidermal hyperplasiaPseudocarcinomatous hyperplasiaMerkel cellsSurface epitheliumAccurate diagnosisCarcinomaTrichoepitheliomaGerminative cellsBasal layerHyperplasiaLichenoid dermatoses with pseudomelanocytic nests vs inflamed melanoma in situ: A comparative study
Panse G, McNiff JM. Lichenoid dermatoses with pseudomelanocytic nests vs inflamed melanoma in situ: A comparative study. Journal Of Cutaneous Pathology 2021, 48: 745-749. PMID: 33350494, DOI: 10.1111/cup.13945.Peer-Reviewed Original ResearchConceptsPseudomelanocytic nestsLichenoid dermatosesDermoepidermal junctionHistopathological featuresPagetoid scatterCytologic atypiaDifferent histopathological featuresSun-damaged skinSignificant cytologic atypiaLichenoid inflammationSolitary melanocytesLichenoid keratosisClinicopathological correlationBiopsy specimensNon-melanocytic lesionsDiagnostic pitfallsAtypical melanocytesDermatosesSingle melanocytesAtypiaMelanomaMelanocytesConfluent growthBenign process
2020
Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein
Ko CJ, Harigopal M, Gehlhausen JR, Bosenberg M, McNiff JM, Damsky W. Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. Journal Of Cutaneous Pathology 2020, 48: 47-52. PMID: 32895985, DOI: 10.1111/cup.13866.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 spike proteinCOVID toesEccrine epitheliumEndothelial cellsSkin biopsiesSpike proteinReverse transcriptase polymerase chain reaction testingSARS-CoV-2 antibodiesPolymerase chain reaction testingSARS-CoV-2 RNAPotential pathogenetic mechanismsPositive immunohistochemical labelingSARS-CoV-2Endothelial depositionPathogenetic mechanismsImmunohistochemical stainingReaction testingImmunohistochemical labelingEccrine glandsRNA ISHImmunohistochemistrySpike RNAGold standardTissue sectionsBiopsyPerniosis during the COVID‐19 pandemic: Negative anti‐SARS‐CoV‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV‐2
Ko CJ, Harigopal M, Damsky W, Gehlhausen JR, Bosenberg M, Patrignelli R, McNiff JM. Perniosis during the COVID‐19 pandemic: Negative anti‐SARS‐CoV‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV‐2. Journal Of Cutaneous Pathology 2020, 47: 997-1002. PMID: 32745281, PMCID: PMC7436569, DOI: 10.1111/cup.13830.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 nucleocapsid proteinPerivascular lymphocytesImmunohistochemical stainingCOVID-19 pandemicSARS-CoV-2 immunohistochemistryNucleocapsid proteinSARS-CoV-2Inflammatory lesionsHistopathologic findingsIntravascular occlusionMicroscopic findingsPerniosisIntravascular materialLymphocytesLesionsPatientsStainingPandemicSuch casesCuffingHistopathologyCasesImmunohistochemistryFindingsProteinEpidermolytic Acanthoma: Findings of a Large Retrospective Study
Roy SF, McNiff JM. Epidermolytic Acanthoma: Findings of a Large Retrospective Study. International Journal Of Gynecological Pathology 2020, 40: e4-e4. PMID: 33290356, DOI: 10.1097/pgp.0000000000000672.Peer-Reviewed Original Research
2019
Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern
Roy SF, Ko CJ, Moeckel GW, Mcniff JM. Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern. Journal Of Cutaneous Pathology 2019, 46: 742-747. PMID: 31157457, DOI: 10.1111/cup.13522.Peer-Reviewed Original ResearchConceptsBenign keratosesDistinctive histopathologic findingsHistological reaction patternEpidermolytic hyperkeratosisReaction patternsBowen's diseaseRetrospective reviewMean ageProminent granular layerHistopathologic findingsEpidermoid cystKeratin immunohistochemistryClinical impressionSeborrheic keratosisPositive stainingNeck areaAbnormal keratinizationKeratohyaline granulesUnique reaction patternReproducible findingsKeratosesCytoplasmic areaGranular layerHyperkeratosisPrevious reportsObservational Study Examining the Diagnostic Practice of Ki67 Staining for Melanocytic Lesions
Vyas NS, Charifa A, Desman GT, Goldberg M, Singh R, Phelps RG, McNiff JM. Observational Study Examining the Diagnostic Practice of Ki67 Staining for Melanocytic Lesions. American Journal Of Dermatopathology 2019, Publish Ahead of Print: &na;. PMID: 31233404, DOI: 10.1097/dad.0000000000001379.Peer-Reviewed Original ResearchMultinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria
Roy SF, Dong D, Myung P, McNiff JM. Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria. Journal Of Cutaneous Pathology 2019, 46: 563-569. PMID: 30927287, DOI: 10.1111/cup.13463.Peer-Reviewed Original ResearchConceptsMultinucleate cell angiohistiocytomaFollicular inductionDiagnostic criteriaPapillary dermal vesselsMononuclear inflammatory infiltrateHistologic diagnostic criteriaLarge case seriesSpecific histologic criteriaWnt/ß-cateninClinicopathologic studyPerifollicular fibrosisCase seriesHistopathologic evidenceInflammatory infiltrateUnderdiagnosed entityFibrohistiocytic originInflamed lesionsHistologic criteriaDermal vesselsHistopathologic entityDermatopathology laboratoryDermatofibromaß-cateninPossible alterationsFibrosis
2012
Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases
Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-323. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaPerineural involvementDesmoplastic stromaMicrocystic adnexal carcinomaBasal cell carcinomaBenign epithelial proliferationsP75 neurotrophin receptorMiddle-aged womenBenign follicular tumorsCK20-positive cellsSmall dermal nervesAdnexal carcinomaCell carcinomaTumor recurrenceTypical presentationBasaloid epitheliumDermal nervesPerineural spaceNeurotrophin receptorBasaloid cellsEpithelial proliferationDermal proliferationDiffuse expressionFollicular tumorsPatients
2001
Perinuclear antineutrophilic cytoplasmic antibody-positive cutaneous polyarteritis nodosa associated with minocycline therapy for acne vulgaris
Schaffer J, Davidson D, McNiff J, Bolognia J. Perinuclear antineutrophilic cytoplasmic antibody-positive cutaneous polyarteritis nodosa associated with minocycline therapy for acne vulgaris. Journal Of The American Academy Of Dermatology 2001, 44: 198-206. PMID: 11174376, DOI: 10.1067/mjd.2001.112218.Peer-Reviewed Case Reports and Technical NotesConceptsLong-term minocycline therapyCutaneous polyarteritis nodosaAntineutrophil cytoplasmic antibodyPolyarteritis nodosaMinocycline therapyCytoplasmic antibodiesSubcutaneous nodulesAcne vulgarisPerinuclear antineutrophil cytoplasmic antibodyAntinuclear antibody panelDiscontinuation of minocyclineDrug-induced lupusUnusual side effectMedium-sized arteriesLong-term treatmentAutoimmune hepatitisOral antibioticsPrednisone therapyLivedo reticularisAutoimmune syndromeAutoimmune disordersCutaneous lesionsBiopsy specimensLower extremitiesHistologic examination
2000
Human TNF Can Induce Nonspecific Inflammatory and Human Immune-Mediated Microvascular Injury of Pig Skin Xenografts in Immunodeficient Mouse Hosts
Kirkiles-Smith N, Tereb D, Kim R, McNiff J, Schechner J, Lorber M, Pober J, Tellides G. Human TNF Can Induce Nonspecific Inflammatory and Human Immune-Mediated Microvascular Injury of Pig Skin Xenografts in Immunodeficient Mouse Hosts. The Journal Of Immunology 2000, 164: 6601-6609. PMID: 10843720, DOI: 10.4049/jimmunol.164.12.6601.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAdultAnimalsCell Adhesion MoleculesDose-Response Relationship, ImmunologicDrug SynergismEndothelium, VascularGraft RejectionHistocompatibility AntigensHumansInterferon-gammaMiceMice, Inbred C57BLMice, SCIDMicrocirculationSevere Combined ImmunodeficiencySkin TransplantationSwineT-LymphocytesTransplantation, HeterologousTumor Necrosis Factor-alphaUp-RegulationConceptsHuman T-cell infiltrationPig skin xenograftsT cell infiltrationSkin xenograftsCell infiltrationHuman TNFIFN-gammaE-selectinT cell-mediated rejectionEndothelial cellsAdhesion moleculesCytokine-mediated injuryNonspecific inflammatory damagePig skin graftsCell-mediated rejectionAppropriate therapeutic targetsImmunodeficient mouse modelPorcine E-selectinEndothelial adhesion moleculesPorcine IFN-gammaClass II moleculesHuman skin allograftsMHC class IPorcine endothelial cellsImmunodeficient mouse hostsPrimary cutaneous follicle center cell lymphoma with follicular growth pattern
Cerroni L, Arzberger E, Puütz B, Hoüfler G, Metze D, Sander C, Rose C, Wolf P, Ruütten A, McNiff J, Kerl H. Primary cutaneous follicle center cell lymphoma with follicular growth pattern. Blood 2000, 95: 3922-3928. PMID: 10845929, DOI: 10.1182/blood.v95.12.3922.Peer-Reviewed Original ResearchConceptsB-cell infiltratesFollicular growth patternGerminal centersPrimary cutaneous follicle center cell lymphomaCutaneous follicle center cell lymphomaPrimary cutaneous follicular lymphomaCutaneous B-cell lymphomaCutaneous follicular lymphomaSame monoclonal populationFollicle center cell lymphomaCutaneous B-cell infiltratesBone marrow biopsyReactive germinal centersB-cell lymphomaFollicle center cellsBcl-2 protein expressionExtracutaneous spreadStaging investigationsPolymerase chain reaction analysisMarrow biopsyImmunophenotypic criteriaNeoplastic folliclesFollicular patternMonoclonal rearrangementSkin lesions
1999
Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma
Grossman D, McNiff J, Li F, Altieri D. Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma. Journal Of Investigative Dermatology 1999, 113: 1076-1081. PMID: 10594755, DOI: 10.1046/j.1523-1747.1999.00776.x.Peer-Reviewed Original ResearchConceptsInvasive malignant melanomaMalignant melanomaDominant negative mutantCultured normal human melanocytesCell cycle progressionApoptosis inhibitor Bcl-2G1 DNA contentNormal human melanocytesSurvivin expressionApoptosis inhibitor survivinApoptosis regulationEndogenous survivinNegative mutantTwo-color flow cytometryGenotoxic stimuliMalignant melanoma cell linesSurvivin dominant-negative mutantCycle progressionMetastatic malignant melanomaApoptosis inhibitorMelanoma cell linesHuman melanocytesMIB-1 stainingApoptosis inhibitionCases of nevusMorphea Limited to the Superficial Reticular Dermis: An Underrecognized Histologic Phenomenon
McNiff J, Glusac E, Lazova R, Carroll C. Morphea Limited to the Superficial Reticular Dermis: An Underrecognized Histologic Phenomenon. American Journal Of Dermatopathology 1999, 21: 315-319. PMID: 10446770, DOI: 10.1097/00000372-199908000-00001.Peer-Reviewed Original ResearchConceptsLichen sclerosus et atrophicusSuperficial reticular dermisSuperficial dermisReticular dermisSpindle cellsDermal dendritic cellsCollagen bundlesTypical histologic featuresImmune accessory cellsSclerosus et atrophicusDermal spindle cellsCases of morpheaDeep reticular dermisElastic fibersDermal elastic fibersDendritic cellsHistologic featuresIndurated skinUnknown etiologyAdditional biopsiesEt atrophicusMorpheaHistologic phenomenonDeep dermisAccessory cellsImmunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma
McNiff J, Eisen R, Glusac E. Immunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma. Journal Of Cutaneous Pathology 1999, 26: 119-124. PMID: 10235376, DOI: 10.1111/j.1600-0560.1999.tb01815.x.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaVariant of trichoblastomaCutaneous lymphadenomaCell carcinomaLangerhans cellsNodular basal cell carcinomaCK20-positive Merkel cellsS100-positive cellsBcl-2CD30-positive cellsCharacteristic immunohistochemical findingsSimilar staining patternLymphoid infiltratesImmunohistochemical findingsStromal stainingTumor groupEpithelial tumorsImmunohistochemical comparisonUncertain histogenesisMerkel cellsTrichoblastomaS100 proteinCD1aLymphadenomaStaining patternEpithelioid Cell Histiocytoma: A Simulant of Vascular and Melanocytic Neoplasms
Glusac E, McNiff J. Epithelioid Cell Histiocytoma: A Simulant of Vascular and Melanocytic Neoplasms. American Journal Of Dermatopathology 1999, 21: 1-7. PMID: 10027517, DOI: 10.1097/00000372-199902000-00001.Peer-Reviewed Original ResearchExtracorporeal photochemotherapy in human and murine graft-versus-host disease
Girardi M, McNiff J, Heald P. Extracorporeal photochemotherapy in human and murine graft-versus-host disease. Journal Of Dermatological Science 1999, 19: 106-113. PMID: 10098701, DOI: 10.1016/s0923-1811(98)00066-8.Peer-Reviewed Original Research
1997
Discoid Lupus Erythematosus Presenting as Asymmetric Posterior Blepharitis
Gloor P, Kim M, McNiff J, Wolfley D. Discoid Lupus Erythematosus Presenting as Asymmetric Posterior Blepharitis. American Journal Of Ophthalmology 1997, 124: 707-709. PMID: 9372736, DOI: 10.1016/s0002-9394(14)70920-1.Peer-Reviewed Original ResearchConceptsDiscoid lupus erythematosusLupus erythematosusPosterior blepharitisSystemic lupus erythematosusCutaneous biopsy specimensDiscoid lupusOphthalmic findingsCutaneous lesionsBiopsy specimensEyelid biopsyEyelid marginErythematosusImmunofluorescence studiesBlepharitisPatientsMisdiagnosisDiagnosisEyelidPresentingBiopsyLupusHistologyLesionsDeformityWomen
1996
Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder.
McNiff J, Cooper D, Howe G, Crotty P, Tallini G, Crouch J, Eisen R. Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder. JAMA Dermatology 1996, 132: 1464-70. PMID: 8961876, DOI: 10.1001/archderm.132.12.1464.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedB-LymphocytesCell DivisionClone CellsGene Rearrangement, beta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGenes, ImmunoglobulinHerpesvirus 4, HumanHumansImmunoglobulin Heavy ChainsImmunophenotypingIn Situ HybridizationLung DiseasesLymphomatoid GranulomatosisMaleMiddle AgedPolymerase Chain ReactionReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaRetrospective StudiesRNA, ViralSkin DiseasesT-LymphocytesConceptsLymphomatoid granulomatosisEpstein-Barr virusEBV RNAB cellsLymphoproliferative disordersPolymerase chain reactionT-cell lymphoproliferative disorderEpstein-Barr virus RNAB-cell lymphoproliferative disordersClonality of lymphocytesT-cell infiltratesAcademic referral centerImmunoglobulin heavy chain gene rearrangementT-cell markersGene rearrangementsT-cell receptor betaChain reactionHeavy chain gene rearrangementClonal immunoglobulin heavy chain gene rearrangementT-cell receptor genesClonal gene rearrangementsChain gene rearrangementAngiocentric infiltratesImmunoglobulin heavy chain geneReferral center